Korean Journal of Food Science and Technology (한국식품과학회지)

Korean Society of Food Science and Technology (한국식품과학회)
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Anti-obesity Effect of Sargassum confusum Ethanol Extract in Obese Rats

알쏭이모자반 주정추출물의 항비만 효과

  • 장여정 (한국식품연구원 신소재 연구단) ;
  • 권상오 ((주)에스앤디 기업부설연구소) ;
  • 여경목 ((주)에스앤디 기업부설연구소) ;
  • 홍미정 ((주)에스앤디 기업부설연구소) ;
  • 김복남 (한림성심대학 관광외식조리과) ;
  • 한대석 (한국식품연구원 신소재 연구단)
  • Received : 2010.09.09
  • Accepted : 2011.01.06
  • Published : 2011.04.30
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Abstract

Effect of Sargassum confusum extract on the reduction of body weight gain and lipid contents in obese rats were evaluated to find natural materials with anti-obesity benefits. After inducing obesity by feeding 42.5% high-fat diet for 5 weeks, each 10 Sprague-Dawley rats were randomly assigned to high-fat diet control (HFD) group and high-fat diet group containing 3% Sargassum confusum extract (HFDSC). Weight gain of HFD group ($2.96{\pm}0.31g/day$) was significantly (p<0.05) higher as compared to that of normal diet (ND) group ($2.19{\pm}0.17g/day$). Weights of adipose tissues of HFD group were higher than those of ND group. Body weight gain of HFDSC group, however, was $2.36{\pm}0.24g/day$, which was significantly (p<0.05) lower by 21% than that of HFD group. In addition, weights of epididymal and perirenal adipose tissues were lower by 15% and 16%, respectively, as compared to those of HFD group. Biochemical analyses showed that concentration of triglyceride, total cholesterol, and fatty acids were significantly (p<0.05) lower in HFDSC group. These results suggest that Sargassum confusum extract has a high potential as an anti-obesity material by reducing weight gain and obesity-related factors in serum.

항비만 소재 개발을 위해 알쏭이모자반 추출물이 고지방식이로 비만이 유도된 흰쥐의 증체량 감소 및 지질저하 효과에 미치는 영향을 살펴보았다. 정상식이군(n=10)을 제외한 20마리의 Spraque-Dawley 계통의 수컷 흰쥐에게 총 칼로리의 42.5%가 지방인 고지방식이를 5주간 급여시킴으로써 비만을 유도하였다. 비만해진 흰쥐는 고지방식이군(HFD)과 알쏭이모자반 3%를 첨가한 고지방식이군(HFDSC)으로 군당 10마리씩 나누어서 실험하였다. 고지방식이를 급여시킨 HFD군의 증체량은 $2.96{\pm}0.31g/day$으로 ND군의 증체량 $2.19{\pm}0.17g/day$보다 유의적으로 높게 나타났으며 (p<0.05), 부고환지방, 신장지방, 내장지방 조직의 중량 역시 ND군보다 유의적으로 높게 나타났다(p<0.05). 그러나 HFDSC군의 증체량은 $2.36{\pm}0.24g/day$으로 HFD군에 비해 21% 낮게 나타났으며, 부고환 및 신장지방 조직 중량 역시 HFD군보다 각각 15%, 16% 낮게 관찰되었다. 또한 HFDSC군의 혈중 중성지방 및 총콜레스테롤, 유리지방산 등 비만관련 인자의 농도도 HFD군보다 유의적으로 낮게 나타났다(p<0.05). 결론적으로 알쏭이모자반 추출물의 급여가 체중 및 지방조직의 증가를 억제하는 점으로 미루어 볼 때, 이는 항비만 효과를 지니는 유효한 소재로 판단된다.

Keywords

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