Korean Journal of Acupuncture

Society for Meridian and Acupoint (경락경혈학회)
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The Effect of Pharmacopuncture with Polygonum cuspidatum Sieb et Zucc. Solution on Collagen-induced Arthritis in Wistar Rats

호장근 약침이 흰쥐의 콜라겐 유발 류마티스 관절염에 미치는 영향

  • Chung, Joon-Hee (Dept. of Meridian & Acupoint, College of Oriental Medicine, Se-Myung University) ;
  • Kim, Yong-Min (Clinical Trial Center for Bio-Industry, Se-Myung University) ;
  • Bak, Jong-Phil (Clinical Trial Center for Bio-Industry, Se-Myung University) ;
  • Ryu, In-Sun (Dept. of Meridian & Acupoint, College of Oriental Medicine, Se-Myung University) ;
  • Leem, Kang-Hyun (Dept. of Herbology, College of Oriental Medicine, Se-Myung University) ;
  • Kim, Chang-Ju (Dept. of Physiology, College of Medicine, Kyung-Hee University) ;
  • Kim, Ee-Hwa (Dept. of Meridian & Acupoint, College of Oriental Medicine, Se-Myung University)
  • 정준희 (세명대학교 한의과대학 경락경혈학교실) ;
  • 김용민 (세명대학교 한방바이오산업 임상지원센터) ;
  • 박종필 (세명대학교 한방바이오산업 임상지원센터) ;
  • 류인선 (세명대학교 한의과대학 경락경혈학교실) ;
  • 임강현 (세명대학교 한의과대학 본초학교실) ;
  • 김창주4 (경희대학교 의과대학 생리학교실) ;
  • 김이화 (세명대학교 한의과대학 경락경혈학교실)
  • Received : 2011.03.03
  • Accepted : 2011.03.23
  • Published : 2011.03.27
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Abstract

호장근(Polygonum cuspidatum Sieb et Zucc.)은 관절통, 만성 기관지염, 황달, 월경분순, 고협압 등의 치료제로 사용되고 있는 약물로서, 본 연구에서는 흰쥐의 류마티스 관절염 병태모델에서 호장근 약침이 류마티스 관절염에 미치는 영향에 대해 관찰하였다. 방법 : 본 연구에서는 bovine type II collagen으로 유발된 흰쥐의 류마티스 관절염 병태모델에서 인체의 족삼리(ST36)에 상응하는 부위에 호장근 약침액을 주입한 후, 체중변화, 족부종의 변화, 족근관절폭의 변화, cytokine의 변화, NOS 발현 양상 등을 관찰하였다. 결과 : 족부종 감소율은 고농도 호장근 약침군에서 높았고, 족근관절폭 감소율은 고농도 및 저농도 호장근 약침군에서 대조군에 비하여 유의하게 높게 관찰되었다. 족부 삼출물 내의 TNF-${\alpha}$ 함량은 고농도 호장근 약침군에서 높았고, IL-$1{\beta}$ 함량은 고농도 및 저농도 호장근 약침군에서 대조군에 비하여 유의하게 높게 관찰되었다. 대뇌 피질에서 NOS 양성 신경세포수는 고농도 및 저농도 호장근 약침군에서 대조군에 비하여 유의하게 낮게 관찰되었다. 결론 : 이상의 결과에서 호장근 약침은 type II collagen으로 유발된 흰쥐의 류마티스 관절염 병태모델에서 염증 반응을 억제하는 효과가 있는 것으로 사려된다.

Keywords

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