Influence of Joint Mobilization on Formalin Induced Pain Prevention of Rats

관절가동술이 흰쥐의 포르말린 유도 통증 예방에 미치는 영향

  • Kang, Jong-Ho (Department of Physical Therapy, Nambu University) ;
  • Kim, Eun-Kyung (Department of Physical Therapy, Seonam University) ;
  • Ro, Hyo-Lyun (Department of Occupational Therapy, Kangwon University)
  • 강종호 (남부대학교 물리치료학과) ;
  • 김은경 (서남대학교 물리치료학과) ;
  • 노효련 (강원대학교 작업치료학과)
  • Received : 2011.04.13
  • Accepted : 2011.05.08
  • Published : 2011.05.31

Abstract

Purpose: The purpose of this study was to determine the preventive effect of joint mobilization on biphasic pain response induced formalin test. Methods: Sprague-dawley rats(n=30) were ramdomly divided into the control group without intervention, sham control group with application of hand contact without mobilization, joint mobilization group with application of hand contact with mobilization. Joint mobilization of knee procedure involved an grade III extension mobilization basically with anterior-posterior gliding of the tibia on the femur. Formalin injection caused biphasic pain response which is lated for 60 minute. The first phase result from primary afferent sensory fiber, wheareas the second phase has been proposed to central sensitization in the central nervous system. Behavioral analysis was performed by digital camera after 5% formalin subcutaneous injection into the dorsal foot. Results: Pain response of joint mobilization group show significant lower than control gorup and sham control group. Conclusion: This result suggest that pre-application of joint mobilization may be effective intervention to prevent the formalin induced pain.

Keywords

References

  1. 이영화, 권원안, 이재홍 등. 척추후관절가동술이 만성요통환자의 통증과 요부안정성에 미치는 영향. 대한물리의학회지. 2008;3(3):203-13.
  2. Abbott FV, Franklin KB, Westbrook RF. The formalin test: scoring properties of the first and second phases of the pain response in rats. Pain. 1995;60(1):91-102. https://doi.org/10.1016/0304-3959(94)00095-V
  3. Aquino RL, Caires PM, Furtado FC et al. Applying Joint Mobilization at Different Cervical Vertebral Levels does not Influence Immediate Pain Reduction in Patients with Chronic Neck Pain: A Randomized Clinical Trial. J Man Manip Ther. 2009;17(2):95-100. https://doi.org/10.1179/106698109790824686
  4. Capone F, Aloisi AM. Refinement of pain evaluation techniques. The formalin test. Ann Ist Super Sanita. 2004;40(2):223-9.
  5. Collins N, Teys P, Vicenzino B. The initial effects of a Mulligan's mobilization with movement technique on dorsiflexion and pain in subacute ankle sprains. Man Ther. 2004;9(2):77-82. https://doi.org/10.1016/S1356-689X(03)00101-2
  6. Esther S, Gordon M, Walter H et al. Decrease in quadriceps inhibition after sacroiliac joint manipulation in patients with anterior knee pain. J Mnipulative Physiol Ther. 1999;22(3):149-53. https://doi.org/10.1016/S0161-4754(99)70128-4
  7. Fernandez-de-Las-Penas C, Alonso-Blanco C, Cleland JA et al. Changes in Pressure Pain Thresholds Over C5-C6 Zygapophyseal Joint After a Cervicothoracic Junction Manipulation in Healthy Subjects. J of Manipulative Physiol Ther. 2008;31(5):332-7. https://doi.org/10.1016/j.jmpt.2008.04.006
  8. Ferreira ML, Ferreira PH, Latimer J et al. Does spinal manipulative therapy help people with chronic low back pain? Aust J Physiother. 2002;48(4):277-84.
  9. Grape S, Tramèr MR. Do we need preemptive analgesia for the treatment of postoperative pain? Best Pract. Res Clin Anaesthesiol. 2007;21(1):51-63. https://doi.org/10.1016/j.bpa.2006.11.004
  10. Green T, Refshauge K, Crosbie J et al. Randomized controlled trial of a passive accessory joint mobilization on acute ankle inversion sprains. Phys Ther. 2001;81(4):984-94.
  11. Kelly DJ, Ahmad M, Brull SJ Preemptive analgesia II: recent advances and current trends. Can J Anaesth. 2001a;48(11):1091-1101. https://doi.org/10.1007/BF03020375
  12. Kelly DJ, Ahmad M, Brull SJ. Preemptive analgesia I: physiological pathways and pharmacological modalities. Can J Anaesth. 2001b;48(10):1000-10. https://doi.org/10.1007/BF03016591
  13. Kisner C, Colby LA. Therapeutic Exercise: Foundations and Techniques. 4th edition. F.A. Davis Co. 2002.
  14. Maitland GD. Vertebral Manipulation 5th ed. Butterworths, London, 1986.
  15. McNair PJ, Portero P, Chiquet C et al. Acute neck pain: cervical spine range of motion and position sense prior to and after joint mobilization. Man Ther. 2007;12(4):390-4. https://doi.org/10.1016/j.math.2006.08.002
  16. Moss P, Sluka K, Wright A. The initial effects of knee joint mobilization on osteoarthritic hyperalgesia. Man Ther. 2007;12(2):109-18. https://doi.org/10.1016/j.math.2006.02.009
  17. Okuda K, Sakurada C, Takahashi M et al. Characterization of nociceptive responses and spinal releases of nitric oxide metabolites and glutamate evoked by different concentrations of formalin in rats. Pain. 2001;92(1-2):107-15. https://doi.org/10.1016/S0304-3959(00)00476-0
  18. Sandler AN. Anesthsiology Clinics of North America: Current concepts in acute pain control. Philadelphia. WB Saunders. 1992.
  19. Savegnago L, Jesse CR, Santos AR et al. Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test. J Pharm Pharmacol. 2008;60(12):1679-86. https://doi.org/10.1211/jpp.60.12.0015
  20. Sevostianova N, Zvartau E, Bespalov A et al. Effects of morphine on formalin-induced nociception in rats. Eur J Pharmacol. 2003;462(1-3):109-13. https://doi.org/10.1016/S0014-2999(03)01345-1
  21. Sherman C, David A, Don H et al. Rehabilitation Therapy for Elbow Disorders in Dogs. Veterinary Surgery. 2009;38(2)301-7. https://doi.org/10.1111/j.1532-950X.2008.00496.x
  22. Shields SD, Cavanaugh DJ, Lee H et al. Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors. Pain. 2010;151(2):422-9. https://doi.org/10.1016/j.pain.2010.08.001
  23. Sluka KA, Skyba DA, Radhakrishnan R et al. Joint mobilization reduces hyperalgesia associated with chronic muscle and joint inflammation in rats. J Pain. 2006;7(8):602-7. https://doi.org/10.1016/j.jpain.2006.02.009
  24. Song XJ, Gan Q, Cao JL et al. Spinal manipulation reduces pain and hyperalgesia after lumbar intervertebral foramen inflammation in the rat. J Manipulative Physiol Ther. 2006;29(1):5-13. https://doi.org/10.1016/j.jmpt.2005.10.001
  25. Sufka KJ, Watson GS, Nothdurft RE, Mogil JS. Scoring the mouse formalin test: validation study. 1998;2(4):351-358. https://doi.org/10.1016/S1090-3801(98)90033-7
  26. Sun OS, Dae PP, Heung DK et al. Pre-emptive infiltration of lidocaine reduces formalin pain behavior in rat. Korean J Anesthesiol. 1995;29(6):790-797.
  27. Tjolsen A, Berge OG, Hunskaar S et al. The formalin test: An evaluation of the method. Pain, 1992;51(1):5-17. https://doi.org/10.1016/0304-3959(92)90003-T
  28. Vaccarino AL, Chorney DA. Descending modulation of central neural plasticity in the formalin pain test. Brain Res. 1994;666(1):104-8. https://doi.org/10.1016/0006-8993(94)90288-7
  29. Vicenzino B, Collins D, Wright A. The initial effects of a cervical spine manipulative physiotherapy treatment on the pain and dysfunction of lateral epicondylalgia. Pain. 1996;68(1):69-74. https://doi.org/10.1016/S0304-3959(96)03221-6
  30. Watson GS, Sufka KJ, Coderre TJ. Optimal scoring strategies and weights for the formalin test in rats. Pain. 1997;70(1):53-8. https://doi.org/10.1016/S0304-3959(96)03299-X