Preventive Nutrition and Food Science

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
권호 표지
DOI QR코드

DOI QR Code

Biological Activity and Inhibition of Non-Enzymatic Glycation by Methanolic Extract of Rosa davurica Pall. Roots

  • Hu, Weicheng (Department of Medical Biotechnology, College of Biomedical Science, Kangwon, National University) ;
  • Han, Woong (Department of Medical Biotechnology, College of Biomedical Science, Kangwon, National University) ;
  • Jiang, Yunyao (Department of Medical Biotechnology, College of Biomedical Science, Kangwon, National University) ;
  • Wang, Myeong-Hyeon (Department of Medical Biotechnology, College of Biomedical Science, Kangwon, National University) ;
  • Lee, Young-Mee (Department of Nursing, Kangwon National University)
  • Received : 2011.05.12
  • Accepted : 2011.07.21
  • Published : 2011.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

The methanolic extract of Rosa davurica Pall. roots exhibited strong antioxidant activity in a 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging assay and was found to be a dose-dependent inhibitor of non-enzymatic formation of advanced glycation end products (AGEs), which are relevant to diabetes complications. HPLC-diode array detector (DAD) analysis of the R. davurica Pall. root extract led to the identification of four compounds: hydrocaffeic acid, catechin, epicatechin, and ellagic acid. Catechin was present in the largest amount and exhibited high antiglycation activity. A CYP3A4 assay was used to investigate potential interactions between drugs and the extract, and results suggest that the R. davurica Pall. root extract had moderate potential for interfering with drug metabolism. The R. davurica Pall. extract did not display anti-inflammatory activity on the level of that for tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) in a lipopolysaccharide (LPS)-stimulated macrophage assay; however, the extract did exhibit low to moderate immunostimulatory activity in a pro-inflammatory macrophage assay. Therefore, we conclude that R. davurica Pall. root is a promising anti-AGE agent with low to moderate risks of associated inflammation or drug interaction.

Keywords

References

  1. An DK. 1998. Illustrated book of Korean medicinal herbs. 6th edition. Kyo-Hack Publishing Co., Ltd., Seoul, Korea. p 374.
  2. Yoshida T, Jin ZX, Okuda T. 1989 Taxifolin apioside and davuriciin M1, a hydrolysable tannin from Rosa davurica. Phytochemistry 28: 2177-2181. https://doi.org/10.1016/S0031-9422(00)97939-1
  3. Cho EJ, Yokozawa T, Rhyu DY, Kim SC, Shibahara N, Park JC. 2003. Study on the inhibitory effects of Korean medicinal plants and their main compounds on the 1,1-diphenyl- 2-picrylhydrazyl radical. Pytomedicine 10: 544- 551. https://doi.org/10.1078/094471103322331520
  4. Sheetz MJ, King GL. 2002. Molecular understanding of hyperglycemia's adverse effects for diabetic complications. Jama 288: 2579-2588. https://doi.org/10.1001/jama.288.20.2579
  5. Farsi DA, Harris CS, Reid L, Bennett SAL, Haddad PS, Martineau LC, Arnason JT. 2007. Inhibition of non-enzymatic glycation by silk extracts from a Mexican land race and modern inbred lines of maize (Zea mays). Phytother Res 22: 108-112.
  6. Suzuki R, Okada Y, Okuyama T. 2003. Two flavone c-glycosides from the style of Zea mays with glycation inhibitory activity. J Nat Prod 66: 564-565. https://doi.org/10.1021/np020256d
  7. Wu CH, Yen GC. 2005. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. J Agric Food Chem 53: 3167-3173. https://doi.org/10.1021/jf048550u
  8. Festa A, D'Agostino RJr, Tracy RP, Haffner SM. 2002. Levels of acute phase proteins and plasminogen activator inhibitor-1 in relation to the development of type 2 diabetes mellitus. Diabetes 51: 1131-1137. https://doi.org/10.2337/diabetes.51.4.1131
  9. Pickup JC, Chusney GD, Thomas SM, Burt D. 2000. Plasma interleukin-6, tumor necrosis factor alpha and blood cytokine production in type 2 diabetes. Life Sci 67: 291-300. https://doi.org/10.1016/S0024-3205(00)00622-6
  10. Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann MM, Ristow M, Boeing H, Pfeiffer AF. 2003. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)- Potsdam Study. Diabetes 52: 812-817. https://doi.org/10.2337/diabetes.52.3.812
  11. Hu W, Heo SI, Wang MH. 2009. Antioxidant and anti-inflammatory activity of Kalopanax pictus leaf. J Korean Soc Appl Biol Chem 52: 360-366. https://doi.org/10.3839/jksabc.2009.064
  12. Singh R, Barden A, Mori T, Beilin L. 2001. Advanced glycation end-products: a review. Diabetologia 44: 129- 146. https://doi.org/10.1007/s001250051591
  13. Huang SM, Wu CH, Yen GC. 2006. Effect of flavonoids on the expression of the pro-inflammatory response in human monocytes induced by ligation of the receptor for AGEs. Mol Nutr Food Res 50: 1129-1139. https://doi.org/10.1002/mnfr.200600075
  14. Rizzi G. 2003. Free radicals in the Maillard reaction. Food Reviews International 19: 375-395. https://doi.org/10.1081/FRI-120025481
  15. Wright JS, Johnson ER, DiLabio GA. 2001. Predicting the activity of phenolic antioxidants: theoretical method, analysis of substituent effects, and application to major families of antioxidants. J Am Chem Soc 123: 1173-1183. https://doi.org/10.1021/ja002455u
  16. Kaminsky LS, Fasco MJ. 1992. Small intestinal cytochromes P450. Crit Rev Toxicol 21: 407-422. https://doi.org/10.3109/10408449209089881

Cited by

  1. Recent development of plant products with anti-glycation activity: a review vol.5, pp.39, 2015, https://doi.org/10.1039/C4RA14211J