Toxicological Research

  • 제28권1호
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  • Pages.33-38
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  • 2012
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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Methanolic Extract Isolated from Root of Lycoris aurea Inhibits Cancer Cell Growth and Endothelial Cell Tube Formation In Vitro

  • Kang, Moo-Rim (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Lee, Chang-Woo (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Yun, Ji-Eun (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Oh, Soo-Jin (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Park, Song-Kyu (College of Pharmacy, Korea University) ;
  • Lee, Ki-Ho (College of Pharmacy, Korea University) ;
  • Kim, Hwan-Mook (College of Pharmacy, Gachon University of Medicine and Science) ;
  • Han, Sang-Bae (College of Pharmacy, Chungbuk National University) ;
  • Kim, Hyoung-Chin (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology) ;
  • Kang, Jong-Soon (Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology)
  • 투고 : 2012.01.15
  • 심사 : 2012.03.28
  • 발행 : 2012.03.31
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초록

In this study, we investigated the effect of methanolic extract isolated from the root of Lycoris aurea (LA) on the growth of cancer cells and the tube formation activity of endothelial cells. Various cancer cells were treated with LA at doses of 0.3, 1, 3, 10 or 30 ${\mu}g/ml$ and LA significantly suppressed the growth of several cancer cell lines, including ACHN, HCT-15, K-562, MCF-7, PC-3 and SK-OV-3, in a dose-dependent manner. We also found that LA induced cell cycle arrest at G2/M phase in ACHN renal cell adenocarcinoma cells. Further study demonstrated that LA concentration-dependently inhibited the tube formation, which is a widely used in vitro model of reorganization stage of angiogenesis, in human umbilical vein endothelial cells. Collectively, these results show that LA inhibits the growth of cancer cells and tube formation of endothelial cells and the growth-inhibitory effect of LA might be mediated, at least in part, by blocking cell cycle progression.

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참고문헌

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피인용 문헌

  1. Radical Intermediate Generation and Cell Cycle Arrest by an Aqueous Extract of Thunbergia Laurifolia Linn. in Human Breast Cancer Cells vol.16, pp.10, 2015, https://doi.org/10.7314/APJCP.2015.16.10.4357
  2. Antiproliferative activities of Amaryllidaceae alkaloids from Lycoris radiata targeting DNA topoisomerase I vol.6, pp.1, 2016, https://doi.org/10.1038/srep38284
  3. extracts from transformed and normal roots vol.68, pp.11, 2016, https://doi.org/10.1111/jphp.12619
  4. Leveraging botanical resources for crop protection: the isolation, bioactivity and structure-activity relationships of lycoris alkaloids pp.1526498X, 2018, https://doi.org/10.1002/ps.5065