Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
권호 표지

The Effect of Porcine Cancellous Bone for Bone Regeneration and Application of Platelet-rich Fibrin in Rabbit Calvarial Defect

가토 두개골 결손부에 이식된 저골(猪骨)과 혈소판 풍부 섬유소의 골형성 효과

  • Park, Jeong Ik (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Jeon, Seong Bae (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Song, Young Il (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Do, Hyung Sik (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Lee, Jin Yong (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Jang, Hyun Seok (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Kwon, Jong Jin (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Rim, Jae Suk (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine) ;
  • Lee, Eui Seok (Department of Oral and Maxillofacial Surgery, Korea University College of Medicine)
  • 박정익 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 전성배 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 송영일 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 도형식 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이진용 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 장현석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 권종진 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 임재석 (고려대학교 의과대학 구강악안면외과학교실) ;
  • 이의석 (고려대학교 의과대학 구강악안면외과학교실)
  • Received : 2012.10.17
  • Accepted : 2012.11.27
  • Published : 2012.11.30
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Abstract

Purpose: The purpose of this study was to evaluate the effectiveness of the platelet-rich fibrin (PRF) used in combination with the porcine cancellous bone as a scaffold, in promoting bone regeneration in the bone defects ofthe rabbit calvaria. Methods: Ten rabbits were used in the study. Three round-shaped defects (diameter 8.0 mm) were created in the rabbit calvaria and were filled with nothing (control group), porcine cancellousbone (Experimental Group 1, porcine bone) and PRF-mixed porcine cancellous bone (Experimental Group 2). TS-GBB is a xenogenic bone-substitute product comprised of a high heat-treated mineralized porcine cancellous bone. Animals were sacrificed at 6 weeks and 12 weeks for the histological and radiographic evaluations. Results: In the micro computed tomography and histological results, the experimental groups 1 and 2 showed more bone formation, remodeling, and calcification than the control group. The new bone formation ratio showed theGroup 2 to be larger than Group 1 at6 and 12 weeks. However, there was no significant difference between the experimental groups 1 and 2 in the new bone formation area, at the 6 and 12 weeks (P>0.05). Conclusion: The PRF-mixed group showed more bone formation than the porcine cancellousbonegroup (TS-GBB), butthere was a no significant difference. The PRF may not lead to enhanced bone healing when grafted with the porcine cancellous bone.

Keywords

References

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