Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Preparation of Benzoyloxy Benzophenone Derivatives and Their Inhibitory Effects of ICAM-1 Expression

  • Kwon, Eun-Mi (Department of Chemistry and Institute of Natural Medicine, Hallym University) ;
  • Kim, Cheol-Gi (Department of Chemistry and Institute of Natural Medicine, Hallym University) ;
  • Goh, Ah-Ra (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University) ;
  • Park, Jin-Seu (Department of Biomedical Science and Research Institute for Bioscience & Biotechnology, Hallym University) ;
  • Jun, Jong-Gab (Department of Chemistry and Institute of Natural Medicine, Hallym University)
  • Received : 2012.02.07
  • Accepted : 2012.03.14
  • Published : 2012.06.20
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Abstract

Benzoyloxy benzophenone derivatives were prepared in 3 steps including DCC coupling, Fries rearrangement and esterification from benzoic acids in 24-89% total yields. Among the prepared 12 benzophenone analogues 1a-1l, the compound 1b having three chloro groups at the para position showed maximum inhibitory effects of ICAM-1 expression but, 1a which have no substituents at all showed no inhibitory activity. This study provides the evidences that benzoyloxy benzophenone derivative, 1b may exert its anti-inflammatory activity by suppressing IFN-${\gamma}$-induced ICAM-1 expression.

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References

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