The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

A Case of Advanced Metastatic Gallbladder Cancer Patients Treated with Oriental Medicine for Four Months

4개월간 한방치료를 받은 전이성 담낭암 환자 증례

  • Jeon, Hyung-Joon (East-West Cancer Center, Dun-San Oriental Hospital of Dae-Jeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Dun-San Oriental Hospital of Dae-Jeon University) ;
  • Lee, Yeon-Weol (East-West Cancer Center, Dun-San Oriental Hospital of Dae-Jeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dun-San Oriental Hospital of Dae-Jeon University)
  • 전형준 (대전대학교 둔산한방병원 동서암센터) ;
  • 조종관 (대전대학교 둔산한방병원 동서암센터) ;
  • 이연월 (대전대학교 둔산한방병원 동서암센터) ;
  • 유화승 (대전대학교 둔산한방병원 동서암센터)
  • Published : 2012.09.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objectives : To observe the therapeutic effects of Oriental herbal prescriptions on an advanced metastatic gallbladder cancer patient. Methods : Hang-Am-Plus (HAP), Gun-Chil-Gye-Bok-Jung (GGJ) and Se-Gan-San (SGS) were prescribed three times a day. To observe the therapeutic effects of oriental medical prescriptions, computed tomography (CT) and magnetic resonance imaging (MRI) images, tumor markers and laboratory tests were carried out regularly. Results : The levels of AST, ALT, ALP, ${\gamma}$-GTP, TB, DB, CA19-9, and CEA decreased significantly from November 29th 2011 to March 14th 2012. There was no interval change on CT images taken between November 15th 2011 and January 3rd 2012. Conclusions : In this case, it could be concluded that Oriental medicinal treatment might be considered as a palliative alternative therapy for the advanced metastatic gallbladder patient.

Keywords

References

  1. Rooholamini SA, Tehrani NS, Razavi MK, Au AH, Hansen GC, Ostrzega N, et al. Imaging of gallbladder carcinoma. Radiographics 1994 Mar; 14(2):291-306.
  2. Furlan A, Ferris JV, Hosseinzadeh K, Borhani AA. Gallbladder carcinoma update: multimodality imaging evaluation, staging, and treatment options. AJR Am J Roentgenol 2008 Nov;191(5):1440-1447. https://doi.org/10.2214/AJR.07.3599
  3. Levy AD, Murakata LA, Rohrmann CA. Gallbladder carcinoma: radiologicpathologic correlation. Radiographics 2001 Mar-Apr;21(2): 295-314.
  4. Henson DE, Albores-Saavedra J, Corle D. Carcinoma of the gallbladder: histologic types, stage of disease, grade, and survival rates. Cancer 1992 Sep 15;70(6):1493-1497. https://doi.org/10.1002/1097-0142(19920915)70:6<1493::AID-CNCR2820700608>3.0.CO;2-U
  5. Ito H, Matros E, Brooks DC, Osteen RT, Zinner MJ, Swanson RS et al. Treatment outcomes associated with surgery for gallbladder cancer: a 20-year experience. J Gastrointest Surg 2004 Feb;8(2):183-190. https://doi.org/10.1016/j.gassur.2003.10.006
  6. Kobayashi A, Oda T, Fukunaga K, Sasaki R, Ohkohchi N et al. Invasion of the Hepatic Artery is a Crucial Predictor of Poor Outcomes in Gallbladder Carcinoma. World J Surg 2012 Mar;36(3):645-650. https://doi.org/10.1007/s00268-011-1413-z
  7. Chew KM, Mak SW, Peh WC. Clinics in diagnostic imaging(137). Singapore Med J 2012 Jan;53(1):70-73
  8. Dong P, Zhang Y, Gu J, Wu W, Li M, Yang J, et al. Wogonin, an active ingredient of Chinese herb medicine Scutellaria baicalensis, inhibits the mobility and invasion of human gallbladder carcinoma GBC-SD cells by inducing the expression of maspin. J Ethnopharmacol 2011 Oct 11;137(3):1373-1380. https://doi.org/10.1016/j.jep.2011.08.005
  9. Seo SH, Yoo HS, Lee YY, Song KC, Choi BL, Cho JH et al. A case of cholangiocarcinoma patient with pancreas metastasis. Korean J Orient Int Med 2002:23(4):735-740.
  10. Kim KS, Yoo HS, Jung TY, Lee YW, Cho CK. Case Series of advanced or metastatic gallbladder cancer patients treated with Hang -Am-Dan. Korean J Orient Int Med 2010: 31(3):667-674.
  11. Willimott S, Barker J, Jones LA, Opara EI. An in vitro based investigation of the cytotoxic effect of water extracts of the Chinese herbal remedy LD on cancer cells. Chem Cent J 2009 Sep 28;3:12.
  12. Ha KT, Kim JK, Lee YC, Kim CH. Inhibitory effect of Daesungki-Tang on the invasiveness potential of hepatocellular carcinoma through inhibition of matrix metalloproteinase-2 and -9 activities. Toxicol Appl Pharmacol 2004 Oct 1;200(1):1-6. https://doi.org/10.1016/j.taap.2004.03.012
  13. Cho JH, Yoo HS, Lee YW, Son CG, Cho CK. Clinical study in 320 cases for cancer patients on the effect Hangamdan. J. Research Institute of Korean Medicine, Daejeon University 2004; 12(2):157-175
  14. Choi W, Jung H, Kim K, Lee S, Yoon S, Park J, et al. Rhus verniciflua Stokes against Advanced Cancer: A Perspective from the Korean Integrative Cancer Center. J Biomed Biotechnol 2012;2012: 874276.
  15. Giang TH, Ngoc TT, Hassell LA. Carcinoma involving the gallbladder: a retrospective review of 23 cases - pitfalls in diagnosis of gallbladder carcinoma. Diagn Pathol 2012 Jan 27;7:10. https://doi.org/10.1186/1746-1596-7-10
  16. American Cancer Society. Cancer facts & figures 2010. Atlanta: American Cancer Society; 2010, p. 1-62.
  17. Pandey M, Pathak AK, Gautam A, Aryya NC, Shukla VK. Carcinoma of the gallbladder. A retrospective review of 99 cases. Dig Dis Sci 2001 Jun;46(6):1145-1151. https://doi.org/10.1023/A:1010652105532
  18. Albores-Saavedra J, Chable-Montero F, Angeles -Albores D, Schwartz A, Klimstra DS, Henson DE. Early gallbladder carcinoma: a clinicopathologic study of 13 cases of intramucosal carcinoma. Am J Clin Pathol 2011 Apr;135(4):637-642. https://doi.org/10.1309/AJCPFRKCFEDLV03Y
  19. Iqbal S, Rankin C, Lenz HJ, Gold PJ, Ahmad SA, El-Khoueiry AB et al. A phase II trial of gemcitabine and capecitabine in patients with unresectable or metastatic gallbladder cancer or cholangiocarcinoma:Southwest Oncology Group study S0202. Cancer Chemother Pharmacol 2011 Dec;68(6):1595-1602. https://doi.org/10.1007/s00280-011-1657-1
  20. Hawkins WG, DeMatteo RP, Jarnagin WR, Ben-Porat L, Blumgart LH, Fong Y. Jaundice predicts advanced disease and early mortality in patients with gallbladder cancer. Ann Surg Oncol 2004 Mar;11(3):310-315. https://doi.org/10.1245/ASO.2004.03.011
  21. Regimbeau JM, Fuks D, Bachellier P, Le Treut YP, Pruvot FR, Navarro F et al. Prognostic value of jaundice in patients with gallbladder cancer by the AFC-GBC-2009 study group. Eur J Surg Oncol 2011 Jun;37(6):505-512. https://doi.org/10.1016/j.ejso.2011.03.135