Journal of the Korean Society of Physical Medicine (대한물리의학회지)

The Korean Society of Physical Medicine (대한물리의학회)
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The Effects of Exercise of Diverse Intensities on the Recovery of Articular Cartilage in Osteoarthritic Rats

다양한 운동 강도가 골관절염 흰쥐의 관절 연골 회복에 미치는 영향

  • Park, Soo-Jin (Department of Physical Therapy, Sunlin College) ;
  • Choi, Young-Chul (Department of Rehabilitation Science, Graduate School of Daegu University) ;
  • Kim, Jin-Sang (Department of Physical Therapy, College of Rehabilitation Science, Daegu University)
  • 박수진 (선린대학교 물리치료과) ;
  • 최영철 (대구대학교 대학원 재활과학과) ;
  • 김진상 (대구대학교 재활과학대학 물리치료학과)
  • Received : 2013.02.06
  • Accepted : 2013.02.20
  • Published : 2013.02.28
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Abstract

PURPOSE: This study examined the effects of exercise of diverse intensities on the recovery of articular cartilage in osteoarthritic rats. METHODS: Over a period of four weeks, the authors applied treadmill exercise programs of diverse intensities to Sprague-Dawley rats, to which intra-articular injection of monosodium iodoacetate(MIA, 3mg/$50{\mu}l$, diluted in saline) was applied to the right knee joint to induce osteoarthritis. The four-week exercise program was not carried out with the control group(CG, n=10). Exercise programs of applicable intensities were applied to the low-intensity exercise group(LEG, n=10), moderate-intensity exercise group(MEG, n=10), and high-intensity exercise group(HEG, n=10) over the four weeks. Observations were made of morphological changes in the rats' articular cartilage, using hematoxylin and eosin stains. RESULTS: there were significant differences(p<.05) in the comparison of articular damage scores between the four groups involved. Articular cartilage damage scores were found to be significantly lower in the LEG, MEG, and HEG than in the CG, indicating that exercise helped with the recovery of cartilage. Of these latter three groups, the MEG showed the highest level of recovery, while the HEG showed the lowest. CONCLUSION: These study results suggest that exercise is effective in treating OA. They also indicate that in prescribing exercise to treat osteoarthritic patients, exercise of moderate intensity is most suitable to patients' physical conditions, rather than low or high intensity, maximizes, and so should be used to maximize the effects of therapy.

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References

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