Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Antioxidant Activities and α-Glucosidase Inhibitory Effect of Water Extracts from Medicinal Plants

약용식물 물 추출물의 항산화 활성 및 α-Glucosidase 저해효과

  • Kim, Hyun Sook (Well-being Bioproducts RIC Center, Kangwon National University) ;
  • Kim, Tae Woo (Well-being Bioproducts RIC Center, Kangwon National University) ;
  • Kim, Dae Jung (Well-being Bioproducts RIC Center, Kangwon National University) ;
  • Lee, Jae Sung (Department of Bio and Health Technology, Kangwon National University) ;
  • Kim, Kyoung Kon (Department of Bio and Health Technology, Kangwon National University) ;
  • Choe, Myeon (Well-being Bioproducts RIC Center, Kangwon National University)
  • 김현숙 (강원대학교 웰빙특산물산업화지역혁신센터) ;
  • 김태우 (강원대학교 웰빙특산물산업화지역혁신센터) ;
  • 김대중 (강원대학교 웰빙특산물산업화지역혁신센터) ;
  • 이재성 (강원대학교 생명건강공학과) ;
  • 김경곤 (강원대학교 생명건강공학과) ;
  • 최면 (강원대학교 웰빙특산물산업화지역혁신센터)
  • Received : 2013.02.27
  • Accepted : 2013.05.29
  • Published : 2013.06.30
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Abstract

We studied the total polyphenol content, DPPH radical scavenging activity, hydroxyl radical scavenging activity and ${\alpha}$-glucosidase inhibition of water extracts from 17 medicinal plants. Total polyphenol contents ranged from 10.0 (Coix lachryma-jobi L, CL) ~ 279.7 (Perilla sikokiana, PS)mg/g. The water extract from medicinal plants were evaluated for its free radical scavenging activities and compared with a commercial antioxidant, ascorbic acid. DPPH radical scavenging activity of Pyrus pyrifolia (PP), Chamaecyparis obtusa L. (COL), Chamaecyparis obtusa F. (COF), and PS were higher than positive control. Higher hydroxyl radical scavenging activity were shown in Acanthopanax senticosus (AS) and Cordyceps militaris (CM) than the other plants. The highest anti-${\alpha}$-glucosidase activity was observed in Cornus officinalis (CO) and Paeonia suffruticosa Andrews (PSA) water extracts. PSA showed not only the higher DPPH radical scavenging activity but also the anti-${\alpha}$-glucosidase activity. The results of our study that PP, COL, COF, PS, AS, CM, CO and PSA could be potential candidates for natural antioxidants.

Keywords

References

  1. Ahn BS, Kim JW, Kim HT, Lee SD and Lee KW. (2010). Antioxidant effects of Hovenia dulcis in the streptozotocininduced diabetic rats. Journal of Veterinary Clinics. 27:366-373.
  2. Baily CJ. (1999). Insulin resistance and antidiabetic drugs. Biochemical Pharmacology. 58:1511-1520. https://doi.org/10.1016/S0006-2952(99)00191-4
  3. Braca A, De Tommasi N, Di Bari L, Pizza C, Politi M and Morelli I. (2001). Antioxidant principles from Bauhinia terapotensis. Journal of Natural Products. 64:892-895. https://doi.org/10.1021/np0100845
  4. Cai L and Kang YJ. (2001). Oxidative stress and diabetic cardiomyopathy: A brief review. Cardiovascular Toxicology. 1:181-193. https://doi.org/10.1385/CT:1:3:181
  5. Choi GY, Han GJ and Ha SC. (2011). ${\alpha}$-glucosidase inhibitory substances exploration isolated from the herb extract. Korean Journal of Food Preservation. 18:620-625. https://doi.org/10.11002/kjfp.2011.18.4.620
  6. Choi JM and Ahn JB. (2012). Functional properties of 50% methanol extracts from different parts of Acanthopanax sessiliflorus. Korean Journal of Food Science and Technology. 44:373-377. https://doi.org/10.9721/KJFST.2012.44.3.373
  7. Chon S, Kwon MK, Oh SJ, Woo JT, Kim SW, Kim JW and Kim YS. (2008). The relationship between antioxidant enzyme activities and diabetic microvascular complications in type 2 diabetic patients. Journal of Kyung Hee University Medical Center. 24:90-97.
  8. Chung MJ, Walker PA, Brown RW and Hogstrand C. (2005). Zinc-mediated gene expression offers protection against H2O2-induced cytotoxicity. Toxicology and Applied Pharmacology. 205:225-236. https://doi.org/10.1016/j.taap.2004.10.008
  9. Drews G, Krippeit-Drews P and Dfer M. (2010). Oxidative stress and beta-cell dysfunction. Pflugers Archiv. 460:703-718. https://doi.org/10.1007/s00424-010-0862-9
  10. Folin AD and Denis W. (1915). A colorimetric method for the determination of phenols(and phenos derivatives) in urine. Journal of Biological Chemistry. 22:305-308.
  11. Fuller CJ, Chandalia M, Garg A, Grundv SM and Jialal I. (1996). RRR-a-tocopheryl acetate supplementation at pharmacologic doses decreases low-density-lipoprotein oxidative susceptibility but not protein glycation in patients with diabetes mellitus. Journal of Clinical Nutrition. 63:753-756. https://doi.org/10.1093/ajcn/63.5.753
  12. Heo SI, Jung MJ, Kim MK and Wang MH. (2007). Antioxidative activities and tyrosinase inhibitory effects of Korean medicinal plants. Journal of the Korean Society for Applied Biological Chemistry. 50:115-119.
  13. Heo SJ, Ahn HY, Kang MJ, Lee JH, Cha JY and Cho YS. (2011). Antioxidative activity and chemical characteristics of leaves, roots, stems and fruits extracts from Acanthopanax senticosus. Journal of Life Science. 21:1052-1059. https://doi.org/10.5352/JLS.2011.21.7.1052
  14. Jeong HJ, Park SB, Kim S and Kim HK. (2007). Total polyphenol content and antioxidative activity of wild grape(Vitis coignetiae) extracts depending on ethanol concentrations. Journal of the Korean Society of Food Science and Nutrition. 36:1491-1496. https://doi.org/10.3746/jkfn.2007.36.12.1491
  15. Jung YT, Lee IS, Whang K and Yu MH. (2012). Antioxidant effects of Picrasma quassioides and Chamaecyparis obtusa(S. et Z) ENDL extracts. Journal of Life Science. 22:354-359. https://doi.org/10.5352/JLS.2012.22.3.354
  16. Kang YH, Park YK, Oh SR and Moon KD. (1995). Studies on the physiological functionality of pine needle and mugwort extracts. Korean Journal of Food Science and Technology. 27:978-984.
  17. Kim DJ, Chung MJ, You JK, Seo DJ, Kim JM and Choe M. (2009). Effect of medicinal plant water extracts on glucoseregulating enzyme activities in Goto-kakizaki rat liver cytosol. Journal of the Korean Society of Food Science and Nutrition. 38:1331-1335. https://doi.org/10.3746/jkfn.2009.38.10.1331
  18. Kim EY, Baik IH, Kim JH, Kim SR and Rhyu MR. (2004). Screening of the antioxidant activity of some medicinal plants. Korean Journal of Food Science and Technology. 36:333-338.
  19. Kim HS and Kang YH. (2010). Antioxidant activities of ethanol extracts of non-edible parts(stalk, stemleaf, seed) from oriental melon. Korean Journal of Plant Resources. 23:451-457.
  20. Kim JS and Choi SY. (2008). Physicochemical properties and antioxidative activities of omija(Schizandra chinensis Bailon). Korean Journal of Food and Nutrition. 21:35-42.
  21. Kim SH, Lee SY, Hong CY, Gwak KS, Yeo HM, Lee JJ and Choi IG. (2011). Whitening and antioxidant activities of essential oils from Cryptomeria japonica and Chamaecyparis obtusa. Journal of Korean Wood Science and Technology. 39:291-302. https://doi.org/10.5658/WOOD.2011.39.4.291
  22. Kim SS and Son SM. (2008). Oxidative stress and cell dysfunction in diabetes: role of ROS produced by mitochondria and NAD(P)H oxidase. Korean Diabetes Journal. 32:389-398. https://doi.org/10.4093/kdj.2008.32.5.389
  23. Kim TH, Kim JM, Baek JM, Kim TW, Kim DJ, Park JH and Choe M. (2011). Antioxidant and whitening effects of Agrimonia pilosa Ledeb water extract. Korean Journal of Medicinal Crop Science. 19:177-194. https://doi.org/10.7783/KJMCS.2011.19.3.177
  24. Korean Ministry of Health and Welfare. (2006). Report on 2005 national health and nutrition survey. Ministry of Health and Welfare. Seoul, Korea. p.75-79.
  25. Kupczyk D, Rybka J, Kedziora-Kornatowska K and Kedziora J. (2010). Melatonin and oxidative stress in elderly patients with type 2 diabetes. Polski Merkuriusz Lekarski. 28:407-409.
  26. Kweon OG, Son JC, Kim SC, Chung SK and Park SW. (1998). Antimicrobial and antioxidative activities from Moutan Cortex extract. Korean Journal of Postharvest Science and Technology. 5:281-285.
  27. Kwon YI, Apostolidis E and Shetty K. (2008). In vitro studies of eggplant(Solanum melongena) phenolics as inhibitors of key enzymes relevant for type 2 diabetes and hypertension. Bioresource Technology. 99:2981-2988. https://doi.org/10.1016/j.biortech.2007.06.035
  28. Lawrence JC, Jill SG, Eric PD, Joyce AD, Donald DL and Mark AY. (2001). Effect of antioxidant treatment of streptozotocininduced diabetic rats on endothelial blood flow, motor nerve conduction velocity and vascular reactivity of epineurial arterioles of the sciatic nerve. Diabetes. 50:1927-1937. https://doi.org/10.2337/diabetes.50.8.1927
  29. Lee HJ, Do JR, Kwon JH and Kim HK. (2012). Physiological properties of Corni fructus extracts based on their extraction condition. Korean Journal of Food Preservation. 19:271-277. https://doi.org/10.11002/kjfp.2012.19.2.271
  30. Lee KD, Kim JS, Bae JO and Yoon HS. (1992). Antioxidative effectiveness of water extract and ether in wormwood(Artemisia montana Pampan). Journal of the Korean Society of Food Science and Nutrition. 21:17-22.
  31. Lee SZ, Park SH and Lee HS. (2001). Change in vivo lipid peroxidation and antioxidant defense system in streptozotocininduced diabetic rats: A time course study. Korean Journal of Nutrition. 34:253-264.
  32. Nepom GT. (1990). A unified hypothesis for the complex genetics of HLA association with IDDM. Diabetes. 39:1153-1157. https://doi.org/10.2337/diabetes.39.10.1153
  33. Ogawa S, Fujieda S, Sakata Y, Ishizaki M, Hisamatsu S, Okazaki K, Ooki Y, Mori M, Itoh M and Korenaga T. (2004). Synthesis and glucosidase inhibitory activity of some N-substituted 5a-carba-${\beta}$-fuco- and ${\beta}$-galactopyranosylamines, and selected derivatives. Bioorganic and Medical Chemistry. 12:6569-6579. https://doi.org/10.1016/j.bmc.2004.09.023
  34. Oku T, Yamada M, Nakamura M, Sadamori N and Nakamura S. (2006). Inhibitory effects of extractive from leaves of Morusalba on human and rat small intestinal disaccharidase activity. British Journal of Nutrition. 95:933-938. https://doi.org/10.1079/BJN20061746
  35. Paolisso G, Maro GD, Galzerano D, Cacciapuoti F, Varricchio G, Varricchio M and D'Onofrio F. (1994). Pharmacological doses of vitamin E and insulin action in elderly subjects. American Journal of Clinical Nutrition. 59:1291-1296. https://doi.org/10.1093/ajcn/59.6.1291
  36. Park CS, Kwon CJ, Choi MA, Park GS and Choi KH. (2002). Antioxidative and nitrite scavenging activities of Cordyceps militaris extracts. Korean Journal of Food Preservation. 9:109-113.
  37. Park S, Jun DW, Park CH, Jang JS, Park SK, Ko BS, Kim BJ and Choi SB. (2004). Hypoglycemic effects of crude extracts of Moutan Radicis Cortex. Journal of Food Science and Technology. 36:472-477.
  38. Shin JH, Choi DJ, Lee SJ, Cha JY and Sung NJ. (2008). Antioxidant activity of black garlic(Allium sativum L.). Journal of Korean Society of Food Science and Nutrition. 37:965-971. https://doi.org/10.3746/jkfn.2008.37.8.965
  39. Son HU, Heo JC, Seo MS and Lee SH. (2010). Effects of Perilla frutescens L. on anti-oxidant and anti-inflammation activity. Korean Journal of Food Preservation. 17:757-761.
  40. Song Y, Wang J, Li Y, Du Y, Arteel GE, Saari JT, Kang YJ and Cai L. (2005). Cardiac metallothionein synthesis in streptozotocin-induced diabetic mice, and its protection against diabetes-induced cardiac injury. American Journal of Pathology. 167:17-26. https://doi.org/10.1016/S0002-9440(10)62949-5
  41. Tai ES, Lim SC, Tan BY, Chew SK, Heng D and Tan CE. (2000). Screening for diabetes mellitus : A two-step approach in individuals with impaired fasting glucose improves detection of those at risk of complications. Diabetes Medicine. 17:771-775. https://doi.org/10.1046/j.1464-5491.2000.00382.x
  42. Yoshida H, Ishikawa T and Nakamura H. (1997). Vitamin E/lipid peroxide ratio and susceptibility of LDL to oxidative modification in non-insulin-dependent diabetes mellitus. Arteriosclerosis, Thrombosis, and Vascular Biology. 17:1438-1446. https://doi.org/10.1161/01.ATV.17.7.1438
  43. Zadeh JN, Rahimi A, Sarmadi1 JT, Tritschler H, Rosen P, Halliwell B and Betteridge DJ. (1997). Relationships between plasma measures of oxidative stress and metabolic control in NIDDM. Diabetologia. 40:647-653. https://doi.org/10.1007/s001250050729

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