Preventive Nutrition and Food Science

  • 제18권3호
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  • Pages.181-187
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  • 2013
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  • 2287-1098(pISSN)
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  • 2287-8602(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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Anticoagulant and Antiplatelet Activities of Artemisia princeps Pampanini and Its Bioactive Components

  • Ryu, Ri (Department of Food Science and Nutrition, Kyungpook National University) ;
  • Jung, Un Ju (Center for Food and Nutritional Genomics Research, Kyungpook National University) ;
  • Kim, Hye-Jin (Foods R&D, CJ Cheil Jedang Corporation) ;
  • Lee, Wonhwa (College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Bae, Jong-Sup (College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University) ;
  • Park, Yong Bok (Department of Genetic Engineering, Kyungpook National University) ;
  • Choi, Myung-Sook (Department of Food Science and Nutrition, Kyungpook National University)
  • 투고 : 2013.06.05
  • 심사 : 2013.08.23
  • 발행 : 2013.09.30
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초록

Artemisia princeps Pampanini (AP) has been used as a traditional medicine in Korea, China and Japan and reported to exhibit various beneficial biological effects including anti-inflammatory, antioxidant, anti-atherogenic and lipid lowering activities; however, its antiplatelet and anticoagulant properties have not been studied. In the present study, we evaluated the effects of an ethanol extract of Artemisia princeps Pampanini (EAP) and its major flavonoids, eupatilin and jaceosidin, on platelet aggregation and coagulation. To determine the antiplatelet activity, arachidonic acid (AA)-, collagen- and ADP (adenosine diphosphate)-induced platelet aggregation were examined along with serotonin and thromboxane A2 ($TXA_2$) generation in vitro. The anticoagulant activity was determined by monitoring the activated partial thromboplastin time (aPTT) and prothrombin time (PT) in vitro. The data showed that EAP and its major flavonoids, eupatilin and jaceosidin, significantly reduced AA-induced platelet aggregation and the generation of serotonin and $TXA_2$, although no significant change in platelet aggregation induced by collagen and ADP was observed. Moreover, EAP significantly prolonged the PT and aPTT. The PT and/or aPTT were significantly increased in the presence of eupatilin and jaceosidin. Thus, these results suggest that EAP may have the potential to prevent or improve thrombosis by inhibiting platelet activation and blood coagulation.

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참고문헌

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