Maxillofacial Plastic and Reconstructive Surgery

Korean Association of Maxillofacial Plastic and Reconstructive Surgeons (대한악안면성형재건외과학회)
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Changes of Compound Muscle Action Potential in Short-term Steroid Therapy for Compression Injury of Rat Sciatic Nerve

백서 좌골신경의 압박손상에 대한 단기간 스테로이드 투여 시 복합근활동전위의 변화

  • Kim, So-Hyun (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Park, Kwang-Won (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Baek, Joon-Seok (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Jung, Tae-Young (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Kim, Mee-Lee (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine) ;
  • Park, Sang-Jun (Department of Dentistry, Busan Paik Hospital, Inje University College of Medicine)
  • 김소현 (인제대학교 의과대학 부산백병원 치과학교실) ;
  • 박광원 (인제대학교 의과대학 부산백병원 치과학교실) ;
  • 백준석 (인제대학교 의과대학 부산백병원 치과학교실) ;
  • 정태영 (인제대학교 의과대학 부산백병원 치과학교실) ;
  • 김미리 (인제대학교 의과대학 부산백병원 치과학교실) ;
  • 박상준 (인제대학교 의과대학 부산백병원 치과학교실)
  • Received : 2012.07.26
  • Accepted : 2013.01.15
  • Published : 2013.01.31
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Abstract

Purpose: Many surgical procedures in oral and maxillofacial area can induce trauma to the peripheral nerve. The aim of the study is to evaluate the effects of short-term steroid therapy on nerve recovery after crush injury. Methods: Sixteen rats were randomly divided into two groups. The right sciatic nerves were exposed, crushed, and sutured. The control group was not given steroids. The test group was injected with dexamethasone disodium phosphate (2 mg/kg body weight/day) for 7 days. In all animals, compound muscle action potential (CMAP) was recorded before and at 1, 7, 14, 21, and 28 days after injury. Results: The amplitude of the CMAP before and at 1, 7, 14, 21, and 28 days after injury were $53.20{\pm}4.80$ mV, $20.12{\pm}5.38$ mV, $30.01{\pm}14.15$ mV, $31.14{\pm}13.56$ mV, $31.73{\pm}16.33$ mV, and $37.23{\pm}16.98$ mV in the control group, and $55.25{\pm}6.72$ mV, $18.62{\pm}6.26$ mV, $29.50{\pm}13.06$ mV, $32.90{\pm}13.226$ mV, $30.17{\pm}11.80$ mV, and $38.41{\pm}12.27$ mV in the test group, respectively. The nerve conduction velocity was $18.82{\pm}3.94$ m/s, $16.73{\pm}3.48$ m/s, $19.60{\pm}2.45$ m/s, $18.68{\pm}3.94$ m/s, $18.02{\pm}3.51$ m/s, and $19.25{\pm}3.88$ m/s in the control group, and $18.94{\pm}3.48$ m/s, $17.28{\pm}2.53$ m/s, $7.57{\pm}2.54$ m/s, $18.77{\pm}2.12$ m/s, $19.48{\pm}1.55$ m/s, and $19.22{\pm}2.97$ m/s in the test group, respectively. There was no significant difference between both groups (P>0.05). Conclusion: This study did not show any therapeutic effect of short-term administration of steroids on injured rat sciatic nerve. Further studies are needed.

Keywords

References

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