좌측 유방 방사선치료 시 4D-CT를 이용한 심장의 체적 및 선량변화에 대한 연구

The Study of Dose Variation and Change of Heart Volume Using 4D-CT in Left Breast Radiation Therapy

  • 박선미 (서울성모병원 방사선종양학과) ;
  • 천금성 (서울성모병원 방사선종양학과) ;
  • 허경훈 (서울성모병원 방사선종양학과) ;
  • 신성필 (서울성모병원 방사선종양학과) ;
  • 김광석 (서울성모병원 방사선종양학과) ;
  • 김창욱 (서울성모병원 방사선종양학과) ;
  • 김회남 (서울성모병원 방사선종양학과)
  • Park, Seon Mi (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Cheon, Geum Seong (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Heo, Gyeong Hun (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Shin, Sung Pil (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Kim, Kwang Seok (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Kim, Chang Uk (Department of Radiation Oncology, Seoul St. Mary's Hospital) ;
  • Kim, Hoi Nam (Department of Radiation Oncology, Seoul St. Mary's Hospital)
  • 투고 : 2012.06.19
  • 심사 : 2013.02.15
  • 발행 : 2013.09.30

초록

목 적: 좌측 유방암 환자 치료 시 4D-CT를 이용하여 기존에 호흡이 고려되지 않았던 치료와 비교하여 심장의 체적 변화와 호흡에 따른 심장의 선량 차이를 알아보고자 한다. 대상 및 방법: 2012년 3월부터 5월까지 본원에 내원한 2문 접선조사로 치료받은 좌측 유방암 환자 10명을 대상으로 하였다. 좌측 유방이 충분히 포함될 수 있도록 FOV (Field-of-view)를 설정하고 자유 호흡 상태의 일반 CT (Free-Breathing CT)와 4D-CT를 통해 영상을 획득하였다. 선량은 50.4 Gy (1.8 Gy/28 fraction)로 필요에 따라 추가적으로 계획용표적체적(PTV: Planning target volume)에 전자선 1문 조사 9 Gy (1.8 Gy/5 Fraction)를 처방하였고 선량체적히스토그람(Dose Volume Histogram)를 이용하여 심장에 받는 선량과 체적을 비교 분석하였다. 결 과: Free-Breathing CT 영상과 4D-CT 영상의 심장에 받는 선량과 체적을 비교 분석한 결과 4D-CT 영상에서 심장의 체적이 최대 40.5% 크게 나타났으며 또한 심장의 총 흡수선량도 최대, 최소, 평균선량이 최대 8.8%, 27.9%, 37.4% 높게 나타났다. 결 론: 4D-CT를 촬영하여 호흡을 고려한 치료계획이 Free-Breathing CT 영상으로 치료 계획한 것 보다 환자의 심장선량이 높게 조사된 것으로 나타났다. 따라서 심장과 근접한 좌측 유방 방사선치료 시 심장박동에 의한 심장의 체적변화를 고려한 치료계획을 세워야 할 것으로 사료된다.

Purpose: We investigate the results of changed heart volume and heart dose in the left breast cancer patients while considering the movements of respiration. Materials and Methods: During the months of March and May in 2012, we designated the 10 patients who had tangential irradiation with left breast cancer in the department of radiation Oncology. With acquired images of free breathing pattern through 3D and 4D CT, we had planed enough treatment filed for covered up the whole left breast. It compares the results of the exposed dose and the volume of heart by DVH (Dose Volume histogram). Although total dose was 50.4 Gy (1.8 Gy/28 fraction), reirradiated 9 Gy (1.8 Gy/5 Fraction) with PTV (Planning Target Volume) if necessary. Results: It compares the results of heart volume and heart dose with the free breathing in 3D CT and 4D CT. It represents the maximum difference volume of heart is 40.5%. In addition, it indicated the difference volume of maximum and minimum, average are 8.8% and 27.9%, 37.4% in total absorbed dose of heart. Conclusion: In case of tangential irradiation (opposite beam) in left breast cancer patients, it is necessary to consider the changed heart volume by the respiration of patient and the heartbeat of patient.

키워드

참고문헌

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