Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
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Study on a Single Oral Dose Toxicity Test of Horse Placenta Hydrolysate Extract in Sprague-Dawley Rats

말 태반 가수분해 추출물의 Sprague-Dawley Rat를 이용한 단회 경구투여 독성시험

  • Yeo, In Ho (Department of Acupuncture & Moxibustion Medicine, Chung-Ju Hospital of Traditional Korean Medicine, Semyung University) ;
  • Kim, Ee Hwa (Department of Meridianology, College of Traditional Korean Medicine, Semyung University) ;
  • Lee, Eun Yong (Department of Acupuncture & Moxibustion Medicine, Chung-Ju Hospital of Traditional Korean Medicine, Semyung University)
  • 여인호 (세명대학교 부속충주한방병원 침구의학과) ;
  • 김이화 (세명대학교 한의과대학 경혈학교실) ;
  • 이은용 (세명대학교 부속충주한방병원 침구의학과)
  • Received : 2014.02.15
  • Accepted : 2014.03.07
  • Published : 2014.03.20
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Abstract

Objectives : The objective of this study is to analyze the single-dose toxicity of horse placenta hydrolysate extracts. Methods : Sprague-Dawley rats were chosen for the study. Doses of horse placenta hydrolysate extracts, 2,000 mg/kg, 1,000 mg/kg and 500 mg/kg, were administered to the experimental group, and the same doses of normal saline solution were administered to the control group. This study was conducted under the approval of the Institutional Animal Ethics Committee. Results : In all 4 groups, no deaths occurred, and the horse placenta hydrolysate extracts administered by oral was over 2,000 mg/kg. No significant changes in the weight between the control group and the experimental group were observed. To check for abnormalities in organs and tissues, we used microscopy to examine representative histological sections of each specified organ, the results showed no significant differences in any organs or tissues. Conclusions : The above findings suggest that treatment with horse placenta hydrolysate extracts is relatively safe. Further studies on this subject should be conducted to yield more concrete evidence.

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References

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