Korean Journal of Medicinal Crop Science (한국약용작물학회지)

The Korean Society of Medicinal Crop Science (한국약용작물학회)
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Effects of Onion Peel Water Extract on the Blood Lipid Profiles in Mice Fed a High-Fat Diet

고지방식이를 섭취한 마우스에서 양파껍질 열수 추출물이 혈중지질에 미치는 영향

  • Lee, Hyun A (Center for Animal Resource Development Research, Wonkwang University) ;
  • Han, Sang Jun (Center for Animal Resource Development Research, Wonkwang University) ;
  • Hong, Sun Hwa (Center for Animal Resource Development Research, Wonkwang University) ;
  • Kim, Ok Jin (Center for Animal Resource Development Research, Wonkwang University)
  • 이현아 (원광대학교 동물자원개발연구센터) ;
  • 한상준 (원광대학교 동물자원개발연구센터) ;
  • 홍선화 (원광대학교 동물자원개발연구센터) ;
  • 김옥진 (원광대학교 동물자원개발연구센터)
  • Received : 2014.04.07
  • Accepted : 2014.05.23
  • Published : 2014.06.30
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Abstract

Onion (Allium cepa L.) is one of the richest sources of flavonoids in human diet. Onion peel contains over 20 times more quercetin than onion flesh. In this study, we studied the effects of onion peel water extract (OPE) on the blood lipid profiles in mice. The onion peel extracts was extracted with hot water. The experimental groups were divided with 3 groups (n = 6) of ICR male mice: normal diet + distilled water (NC), high-fat diet + distilled water (HF), high-fat diet + onion peel water extract 20 mg/kg (OPE-20). The oral administration was conducted daily. The experimental period was 7 weeks. Onion peel water extract showed higher concentration of polyphenol gallic acid and anti-oxidant trolox equivalent than the ethanol extract. The body weight gain and food efficiency ratio was significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The epididymal fat and retroperitoneal fat showed significantly lower weights and sizes in the OPE-20 group as compared with HF group (p < 0.05). The serum levels of total cholesterol, LDL cholesterol and triglyceride were significantly lower in the OPE-20 group as compared with HF group (p < 0.05). The OPE-20 group showed higher HDL cholesterol concentration than HF group (p < 0.05). Atherogenic index was ignificantly lower in as compared with HF group (p < 0.05). The serum levels of glucose, GOT and GPT were significantly lower in the OPE-20 group as compared with HF group (p < 0.05). In these results, we suggests that onion peel water extracts supplementation can reduces the serum lipid components and improves the lipid metabolism in hyperlipidemic mice induced with a high-fat diet.

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References

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