Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Medicinal Plants Combating Against Cancer - a Green Anticancer Approach

  • Sultana, Sabira (University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur) ;
  • Asif, Hafiz Muhammad (Department of Eastern Medicine & Surgery, Faculty of Medical & Health Sciences, The University of Poonch) ;
  • Nazar, Hafiz Muhammad Irfan (University College of Pharmacy, The University of Punjab) ;
  • Akhtar, Naveed (University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur) ;
  • Rehman, Jalil Ur. (University College of Conventional Medicine, Faculty of Pharmacy & Alternative Medicine, The Islamia University of Bahawalpur) ;
  • Rehman, Riaz Ur. (Department of Eastern Medicine & Surgery, Directorate of Medical Sciences, GCU)
  • Published : 2014.06.15
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Abstract

Cancer is the most deadly disease that causes the serious health problems, physical disabilities, mortalities, and morbidities around the world. It is the second leading cause of death all over the world. Although great advancement have been made in the treatment of cancer progression, still significant deficiencies and room for improvement remain. Chemotherapy produced a number of undesired and toxic side effects. Natural therapies, such as the use of plant-derived products in the treatment of cancer, may reduce adverse and toxic side effects. However, many plants exist that have shown very promising anticancer activities in vitro and in vivo but their active anticancer principle have yet to be evaluated. Combined efforts of botanist, pharmacologist and chemists are required to find new lead anticancer constituent to fight disease. This review will help researchers in the finding of new bioactive molecules as it will focus on various plants evaluated for anticancer properties in vitro and in vivo.

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References

  1. Aied MA, Rola A, Abdul MA, et al (2013). Induction of Caspase-9, Biochemical Assessment and Morphological Changes Caused by Apoptosis in Cancer Cells Treated with Goniothalamin Extracted from Goniothalamus macrophyllus. Asian Pac J Cancer Prev, 14, 6273-6280. https://doi.org/10.7314/APJCP.2013.14.11.6273
  2. Anand P, Kunnumakkara AB, Kunnumakara A (2008). Cancer is a Preventable Disease that Requires Major Lifestyle Changes. Pharm Res, 25, 2097-116. https://doi.org/10.1007/s11095-008-9661-9
  3. Anesini CA, Genaro, Cremaschi G, et al (2011). In vivo antitumor activity of Larrea divaricata C. comparison of two routes of administration, Phytomed, 5, 41-45.
  4. Ariga T and Seki T (2006). Antithrombotic and anticancer effects of garlic-derived sulfur compounds: A review. Bio Factors, 26, 93-103.
  5. Arunee H, Kornkanok I, Nanteetip L, Daniel S (2014). Ethanolic Extract from Derris scandens Benth Mediates Radiosensitzation via Two Distinct Modes of Cell Death in Human Colon Cancer HT-29 Cells. Asian Pac J Cancer Prev, 15, 1871-7. https://doi.org/10.7314/APJCP.2014.15.4.1871
  6. Bertino JR (1997). Irinotecan for colorectal cancer. Semin Oncol, 24, 18-23.
  7. Bharali R, Azad MR, Tabassum J (2003). Chemopreventive action of Boerhaavia diffusa on DMBA- induced skin carcinogenesis in mice. Ind J Physiol Pharmacol, 47, 459-64.
  8. Chik W, Dalila W, Azura A, Parveen J (2010). Purification and cytotoxicity assay of Tomato (Lycopersicum esculentum) leaves methanol extract as potential anticancer agent. J Appl Sci, 10, 3283-8. https://doi.org/10.3923/jas.2010.3283.3288
  9. Choi SG, Kim J, Sung ND, et al (2007). Anthraquinones, Cdc25B phosphatase inhibitors, isolated from the roots of Polygonum multiflorum Thunb. Nat Prod Res, 21, 487-93. https://doi.org/10.1080/14786410601012265
  10. Cragg GM and Newman DJ (2005). Plant as source of anticancer agents. J Ethnopharmacol, 100, 72-9. https://doi.org/10.1016/j.jep.2005.05.011
  11. Creemers GJ, Bolis G, Gore M, et al (1996). Topotecan, an active drug in the second-line treatment of epithelial ovarian cancer: results of a large European phase II study. J Clin Oncol, 14, 3056-61.
  12. De Rezende AA, Graf U, Guterres ZR, Kerr WE, Spano MA (2009). Protective effects of proanthocyanidins of grape (Vitis vinifera L.) seeds on DNA damage induced by Doxorubicin in somatic cells of Drosophila melanogaster. Food Chem Toxicol, 47, 1466-72. https://doi.org/10.1016/j.fct.2009.03.031
  13. Ferlay, Soerjomataram I, Ervik M, Dikshit R, Eser S, et al (2012). Globocan, v 1.0, Cancer Incidence and Mortality Worldwide: IARC cancer Base No. 11 [Internet]. Lyon, Fance: International agency for research on cancer: 2013; Available from: http://globocan.iarc.fr.accessed on 13/12/2013.
  14. Gennari C, Castoldi D and Sharon O (2007). Product with taxol-like tumor activity: approaches to eleutherobin and dicytostatin. Pure and Appl Chem, 79, 173-80.
  15. George VC, Kumar N, Rajkumar V, Suresh PK, Kumar RA (2012). Quantitative assessment of the relative antineoplastic potential of the n-butanolic leaf extract of Annona Muricata Linn. in normal and immortalized human cell lines. Asian Pac J Cancer Prev, 13, 699-704. https://doi.org/10.7314/APJCP.2012.13.2.699
  16. Hamayun M, Khan SA, Sohn EY, In-Jung Lee (2006). Folk medicinal knowledge and conservation status of some economically valued medicinal plants of District Swat, Pakistan. Lyonia. A journal of ecology and application, 11, 101-13
  17. Hartwell JL (1982). Plants used Against Cancer. A survey Lawrence, Massachusetts. MA. Quarterman Publications, pp 438- 39.
  18. Harvey AL (1999). Medicines from nature: are natural products still relevant to drug discovery. Trends Pharmacol Sci, 20, 196-8. https://doi.org/10.1016/S0165-6147(99)01346-2
  19. Irigaray P, Newby JA, Clapp R (2007). Lifestyle-related factors and environmental agents causing cancer: an overview. Biomed Pharmacother, 61, 640-58. https://doi.org/10.1016/j.biopha.2007.10.006
  20. Itokawa H, Wang X, Lee K-H (2005). Homoharringtonine and related compounds. In: Cragg GM, Kingston, DGI, Newman D, (eds). Anticancer agents from natural products. Boca Raton, Florida, Brunner-Routledge Psychology Press, Taylor & Francis Group, 47-70.
  21. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. A cancer journal for clinicians, 61, 69-90. https://doi.org/10.3322/caac.20107
  22. Jeong JB, Jeong HJ, et al (2007). Cancer-preventive peptide lunasin from Solanum nigrum L. inhibits acetylation of core histones H3 and H4 and phosphorylation of retinoblastoma protein (Rb), J Agric Food Chem, 55, 10707-13. https://doi.org/10.1021/jf072363p
  23. Jing J, Ruolin Y, Yang L (2008). The anticancer activity of compounds in lipophilic fraction of Daucus carota, J Guiyang Med Coll, 5, 14.
  24. Jun L, Chun-YX, Shi-Zhong C, et al (2013). Senescence effects of Angelica sinensis polysaccharides on human acute myelogenous leukemia stem and progenitor cells. Asian Pac J Cancer Prev, 14, 6549-56. https://doi.org/10.7314/APJCP.2013.14.11.6549
  25. Jung MJ, Yin Y, Heo SI, Wang MH (2008). Antioxidant and anticancer activities of extract from Artemisia capillaries. Korean J Pharmacog, 39, 194-8.
  26. Kang JH, Song KH, Woo JK, et al (2011). Ginsenoside Rp1 from Panax ginseng exhibits anti-cancer activity by down-regulation of the IGF-1R/Akt pathway in breast cancer cells. Plant Foods Hum Nutr, 66, 298-305. https://doi.org/10.1007/s11130-011-0242-4
  27. Kantarjian HM, Brien S, Anderlini P, Talpaz M (1996). Treat- ment of chronic myelogenous leukemia: current status and investigational options. Blood, 87, 3069-81.
  28. Kapadia GJ, Tokuda H, Konoshima T, Nishino H (1996). Chemoprevention of lung and skin cancer by Beta vulgaris (beet) root extract. Cancer Lett, 100, 211-214. https://doi.org/10.1016/0304-3835(95)04087-0
  29. Karmakar SR, Biswas SJ, Khuda-Bukhsh AR (2010). Anti-carcinogenic potentials of a plant extract (Hydrastis canadensis): I. Evidence from in vivo studies in mice (Mus musculus). Asian Pac J Cancer Prev, 11, 545-51.
  30. Khajure P V and Rathod JL (2011). Potential anticancer activity of Acanthus ilicifolius extracted from The Mangroves Forest Of Karwar, West Cost Of India. World J Sci Tech, 1, 01-06. https://doi.org/10.4236/wjnst.2011.11001
  31. Knudson AG (2001). "Two genetic hits (more or less) to cancer". Nature reviews. Cancer, 1, 157-62. https://doi.org/10.1038/35101031
  32. Kumar S, Ramamurthy, Pittu VP, et al (2011). In vitro Cytotoxic Activity of Methanol and Acetone Extracts of Parthenum hysterophorus Flower On A549 Cell Lines. Int J Pharma Sci Rev Res, 10, 95-99.
  33. Kundusen S, Gupta M, Mazumder UK, et al (2011). Antitumor Activity of Citrus maxima (Burm.) Merr. Leaves in Ehrlich's Ascities Carcinoma Cell- Treated Mice. Pharmacology, 138737. doi: 10.5402/2011/138737.
  34. Kuttan R, Bhanumathy P, Nirmala K, George MC (1985). Potential anticancer activity of turmeric (Curcuma longa). Cancer Lett, 29, 197-202. https://doi.org/10.1016/0304-3835(85)90159-4
  35. Lakshmi S, Padmaja G, Remani P (2011). Antitumour effects of Isocurcumenol isolated from Curcuma zedoaria rhizomes on human and murine cancer cells. Int J Med Chem, 6, 1-13.
  36. Lin JY, Liu SY (1986). Studies on the antitumor lectins isolated from the seeds of Ricinus communis (castor bean). Toxicon, 24, 757-65. https://doi.org/10.1016/0041-0101(86)90100-5
  37. Liu W, Li SY, Huang XE, Cui JJ, Zhao T, Zhang H (2012). Inhibition of tumor growth in vitro by a combination of extracts from Rosa roxburghii Tratt and Fagopyrum cymosum. Asian Pac J Cancer Prev, 13, 2409-14. https://doi.org/10.7314/APJCP.2012.13.5.2409
  38. Lorence AF, Bolivar M, Nessler CL (2004). Camptothecin and 10-hydroxycamptothecin from Camptotheca acuminata hairy roots, physiology and biochemistry. Plant Cell Reports, 22, 437-41. https://doi.org/10.1007/s00299-003-0708-4
  39. Mahadik VJ, Piyusha BP, Pandip B P, Nilofar SN (2011). Evaluation of antitumor and antioxidant activity of Vitis vinifera L. against ehrlich ascites carcinoma induced mice, Int J Pharma Res Devel, 3, 98-104.
  40. Mija CJ, Chung CK, Jeong Y, Shi Ham SH (2010). Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells. Nutr Res Pract, 4, 177-82. https://doi.org/10.4162/nrp.2010.4.3.177
  41. Nagamine MK, Da Silva TC, Matsuzaki P, et al (2009). Cytotoxic effects of butanolic extract from Pfaffia paniculata (Brazilian ginseng) on cultured human breast cancer cell line MCF-7. Exp Toxicol Pathol, 61, 75-82. https://doi.org/10.1016/j.etp.2008.01.017
  42. Nostro A, Germono MP, Dangelo V, Cannatelli MA (2011). Extraction methods and bioautography for evaluation of medicinal plant antimicrobial activity. Lett Appl Microbiol, 30, 379-84.
  43. Pandey M, Debnath M, Gupta S, Chikara SK (2011). Phytomedicine: An ancient approach turning into future potential source of therapeutics. J Pharma Phytothera, 3, 27-37.
  44. Patel S, Gheewala N, Suthar A, Shah A (2009). In vitro cytotoxicity of Solanum nigrum extract against Hella cell lines and vero cell line. Int J Pharm Pharma Sci, 1, 38-46.
  45. Potmeisel M, Pinedo H (1995). Camptothecins: new anticancer agents. Boca Raton, Florida, CRC Press, 149-50.
  46. Powell RG, Weisleder D, Smith CRJR, Rohwedder WK (1970). Structures of harringtonine, isoharringtonine, and homoharringtonine. Tetrahedron Lett, 11, 815-18. https://doi.org/10.1016/S0040-4039(01)97839-6
  47. Rashid H, Gafur, GM, Sadik, Rahman MAA (2002). Biological activities of a new derivative from Ipomoea turpithum. Pakistan J Biol Sci, 5, 968-9. https://doi.org/10.3923/pjbs.2002.968.969
  48. Raval BP, Shah TG, Patel BA, Patel RK, Suthar MP (2010). Potent anticancer activity of Nigella sativa seeds. Archives Appl Sci Res, 2, 52-6.
  49. Rowinsky EK, Onetto N, Canetta RM, Arbuck SG (1992). Taxol- the 1st of the texanes, an important new class of anti- tumor agents. Semin Oncol, 19, 646-62.
  50. Saha P, Mazumder UK, Haldar PK, et al (2011). Anticancer activity of Cucurbita maxima against Ehrlich as-cites carcinoma. Int J Res Pharm Sci, 2, 52-59.
  51. Saraydin SU, Tuncer E, Tepe B, et al (2013). Antitumoral effects of Melissa officinalis on breast cancer in vitro and in vivo. Asian Pac J Cancer Prev, 13, 2765-70. https://doi.org/10.7314/APJCP.2012.13.6.2765
  52. Sharma H, Parihar L, Parihar P (2011). Review on anticancerous properties of some medicinal plants. J Med Plant Res, 5, 1818-35.
  53. Sharma JVC, Pitchaiah G, Satyavati D, et al (2011). In vitro anticancer activity of methanolic extract of roots of Glochidion zeylanicum (Gaertn.). Int J Res Pharma Biomed Sci, 2, 760-4.
  54. Sharma V (2011). Flowers of Woodfordia fruticosa exhibit in vitro cytotoxic effect on HEP-2 and SK-N-MC cancer cells. Biotechnol Bioinf Bioeng, 1, 229-233.
  55. Shilpa PN, Sivaramakrishnan V, Devaraj N (2012). Induction of apoptosis by methanolic extract of Rubia cordifolia Linn in HEp-2 cell line is mediated by reactive oxygen species. Asian Pac J Cancer Prev, 13, 2753-8. https://doi.org/10.7314/APJCP.2012.13.6.2753
  56. Shoeb M (2006). Anticancer agents from medicinal plants. Bang J Pharmacol, 1, 35-41.
  57. Simsek EN, Uysal T (2013). In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells. Asian Pac J Cancer Prev, 14, 6791-5. https://doi.org/10.7314/APJCP.2013.14.11.6791
  58. Sreelatha S, Dinesh1, Uma C (2012) Antioxidant Properties of Rajgira (Amaranthus paniculatus) Leaves and Potential Synergy in Chemoprevention. Asian Pac J Cancer Prev, 13, 2775-80. https://doi.org/10.7314/APJCP.2012.13.6.2775
  59. Stahelin H (1973). Activity of a new glycosidic lignan derivative (VP 16-213) related to podophyllotoxin in experimental tumors. Eur J Cancer, 9, 215-21. https://doi.org/10.1016/S0014-2964(73)80021-0
  60. Sumithra M, Anbu J, Nithya S, Ravichandiran V (2011). Anticancer activity of methanolic leaves Extract of Avicennia officinalis on Ehrlich ascities Carcinoma cell lines in Rodents. Int J Pharm Tech Res, 3, 1290-2.
  61. Svoboda GH, Poore GA, Simpson P J, Boder GB (1996). Alkaloids of Acronychia Baueri Schott: Isolation of the alkaloids and a study of the antitumor and other biological properties of acronycine. J Pharma Sci, 55, 758-68.
  62. Thomson M, Ali M (2003). Garlic [Allium sativum]: a review of its potential use as an anti- cancer agent. Curr Cancer Drug Targets, 3, 67-81. https://doi.org/10.2174/1568009033333736
  63. Valcic S, Timmermann BN, Alberts DS, et al (1996). Inhibitory effect of six green tea catechins and caffeine on the growth of four selected human tumor cell lines. Anticancer Drugs, 7, 461-8. https://doi.org/10.1097/00001813-199606000-00011
  64. Waraporn Y, Athikom S, Roongtawan S (2013). Suppression of human fibrosarcoma cell metastasis by Phyllanthus emblica extract in vitro. Asian Pac J Cancer Prev, 14, 6863-7. https://doi.org/10.7314/APJCP.2013.14.11.6863
  65. Wei-QG, Liang-ZL, Zhuo-YH, et al (2013). Anti-proliferative effects of Atractylis lancea (Thunb.) DC. via Down-regulation of the c-myc/hTERT/Telomerase Pathway in Hep-G2 Cells. Asian Pac J Cancer Prev, 14, 6363-7. https://doi.org/10.7314/APJCP.2013.14.11.6363
  66. William CS, Kwok N L (2007). In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Letters, 252, 43-54. https://doi.org/10.1016/j.canlet.2006.12.001
  67. Woo HY, Park KY, Rhu CH, et al (2006). $\beta$-Lapachone, a Quinone Isolated from Tabebuia avellanedae, Induces apoptosis in HepG2 hepatoma cell line through induction of bax and activation of caspase. J Med Food, 9, 161-8. https://doi.org/10.1089/jmf.2006.9.161
  68. Yadav B, Bajaj A, Saxena M, Saxena AK (2010) . In vitro anticancer activity of the leaves of Withania somnifera against various human cancer cell lines. Indian J Pharm Sci, 72, 659-63. https://doi.org/10.4103/0250-474X.78543
  69. Yue Fu, Tze-chen H, Junqiao G, et al (2004). Licochalcone- A: A novel flavonoid isolated from licorice root (Glycyrrhiza glabra), causes G2 and late-G1 arrests in androgen-independent PC-3 prostate cancer cells. Biochem Biophys Res Comm, 322, 263-70. https://doi.org/10.1016/j.bbrc.2004.07.094

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