Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
권호 표지
DOI QR코드

DOI QR Code

Is catechol-o-methyltransferase gene polymorphism a risk factor in the development of premenstrual syndrome?

  • Deveci, Esma Ozturk (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University) ;
  • Incebiyik, Adnan (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University) ;
  • Selek, Salih (Psychiatry Department, Faculty of Medicine, Istanbul Medeniyet University) ;
  • Camuzcuoglu, Aysun (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University) ;
  • Hilali, Nese Gul (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University) ;
  • Camuzcuoglu, Hakan (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University) ;
  • Erdal, Mehmet Emin (Medical Faculty, Department of Medical Biology and Genetics, Mersin University) ;
  • Vural, Mehmet (Department of Gynecology and Obstetrics, Faculty of Medicine, Harran University)
  • Received : 2014.02.21
  • Accepted : 2014.05.21
  • Published : 2014.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Objective: The objective of this study was to investigate whether there was a correlation between catechol-o-methyltransferase (COMT) gene polymorphism, which is believed to play a role in the etiology of psychotic disorders, and premenstrual syndrome (PMS). Methods: Fifty-three women with regular menstrual cycles, aged between 18 and 46 years and diagnosed with PMS according to the American Congress of Obstetrics and Gynecology criteria were included in this study as the study group, and 53 healthy women having no health problems were selected as the controls. Venous blood was collected from all patients included in the study and kept at $-18^{\circ}C$ prior to analysis. Results: There was no significant difference between the groups in terms of demographic features such as age, body mass index, number of pregnancies, parity, and number of children. No statistically significant difference was observed in terms of COMT gene polymorphism (p=0.61) between women in the PMS and the control groups. However, a significant difference was found between arthralgia, which is an indicator of PMS, and low-enzyme activity COMT gene (Met/Met) polymorphism (p=0.04). Conclusion: These results suggested that there was no significant relationship between PMS and COMT gene polymorphism. Since we could not find a direct correlation between the COMT gene polymorphism and PMS, further studies including alternative neurotransmitter pathways are needed to find an effective treatment for this disease.

Keywords

References

  1. O'Brien PM, Backstrom T, Brown C, Dennerstein L, Endicott J, Epperson CN, et al. Towards a consensus on diagnostic criteria, measurement and trial design of the premenstrual disorders: the ISPMD Montreal consensus. Arch Womens Ment Health 2011;14:13-21. https://doi.org/10.1007/s00737-010-0201-3
  2. Zarei S, Mosalanejad L, Ghobadifar MA. Blood glucose levels, insulin concentrations, and insulin resistance in healthy women and women with premenstrual syndrome: a comparative study. Clin Exp Reprod Med 2013;40:76-82. https://doi.org/10.5653/cerm.2013.40.2.76
  3. Wichianpitaya J, Taneepanichskul S. A comparative efficacy of low-dose combined oral contraceptives containing desogestrel and drospirenone in premenstrual symptoms. Obstet Gynecol Int 2013;2013:487143.
  4. Cirillo PC, Passos RB, Bevilaqua MC, Lopez JR, Nardi AE. Bipolar disorder and Premenstrual Syndrome or Premenstrual Dysphoric Disorder comorbidity: a systematic review. Rev Bras Psiquiatr 2012;34:467-79. https://doi.org/10.1016/j.rbp.2012.04.010
  5. Huo L, Straub RE, Roca C, Schmidt PJ, Shi K, Vakkalanka R, et al. Risk for premenstrual dysphoric disorder is associated with genetic variation in ESR1, the estrogen receptor alpha gene. Biol Psychiatry 2007;62:925-33. https://doi.org/10.1016/j.biopsych.2006.12.019
  6. Magnay JL, El-Shourbagy M, Fryer AA, O'Brien S, Ismail KM. Analysis of the serotonin transporter promoter rs25531 polymorphism in premenstrual dysphoric disorder. Am J Obstet Gynecol 2010;203:181e1-5. https://doi.org/10.1016/j.ajog.2010.02.043
  7. Basterra V, Sanchez-Torres AM, Rosa A, Fananas L, Cuesta MJ, Peralta V. Influence of genetic variability at the COMT gene on TMT-B performance in psychotic patients and their healthy siblings. Psychiatr Genet 2012;22:92-5. https://doi.org/10.1097/YPG.0b013e32834c0c0d
  8. Arts B, Simons CJ, Drukker M, van Os J. Antipsychotic medications and cognitive functioning in bipolar disorder: moderating effects of COMT Val108/158 Met genotype. BMC Psychiatry 2013;13:63. https://doi.org/10.1186/1471-244X-13-63
  9. Benedetti F, Dallaspezia S, Locatelli C, Radaelli D, Poletti S, Lorenzi C, et al. Recurrence of bipolar mania is associated with catechol- O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord 2011;132:293-6. https://doi.org/10.1016/j.jad.2011.02.022
  10. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. J Affect Disord 2010;125:341-4. https://doi.org/10.1016/j.jad.2010.01.005
  11. Wu K, O'Keeffe D, Politis M, O'Keeffe GC, Robbins TW, Bose SK, et al. The catechol-O-methyltransferase Val(158)Met polymorphism modulates fronto-cortical dopamine turnover in early Parkinson's disease: a PET study. Brain 2012;135:2449-57. https://doi.org/10.1093/brain/aws157
  12. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine. Eur Psychiatry 2010;25:476-8.
  13. Baldinger P, Hahn A, Mitterhauser M, Kranz GS, Friedl M, Wadsak W, et al. Impact of COMT genotype on serotonin-1A receptor binding investigated with PET. Brain Struct Funct 2013 Aug 9 [Epub]. http://doi.dx.org/10.1007/s00429-013-0621-8.
  14. Kurnianingsih YA, Kuswanto CN, McIntyre RS, Qiu A, Ho BC, Sim K. Neurocognitive-genetic and neuroimaging-genetic research paradigms in schizophrenia and bipolar disorder. J Neural Transm 2011;118:1621-39. https://doi.org/10.1007/s00702-011-0672-z
  15. Freeman EW, Sammel MD, Lin H, Rickels K, Sondheimer SJ. Clinical subtypes of premenstrual syndrome and responses to sertraline treatment. Obstet Gynecol 2011;118:1293-300. https://doi.org/10.1097/AOG.0b013e318236edf2
  16. Borenstein JE, Dean BB, Leifke E, Korner P, Yonkers KA. Differences in symptom scores and health outcomes in premenstrual syndrome. J Womens Health (Larchmt) 2007;16:1139-44. https://doi.org/10.1089/jwh.2006.0230
  17. Heinemann LA, Minh TD, Filonenko A, Uhl-Hochgraber K. Explorative evaluation of the impact of severe premenstrual disorders on work absenteeism and productivity. Womens Health Issues 2010;20:58-65. https://doi.org/10.1016/j.whi.2009.09.005
  18. Chocano-Bedoya PO, Manson JE, Hankinson SE, Willett WC, Johnson SR, Chasan-Taber L, et al. Dietary B vitamin intake and incident premenstrual syndrome. Am J Clin Nutr 2011;93:1080-6. https://doi.org/10.3945/ajcn.110.009530
  19. Chuong CJ, Dawson EB, Smith ER. Vitamin A levels in premenstrual syndrome. Fertil Steril 1990;54:643-7. https://doi.org/10.1016/S0015-0282(16)53822-9
  20. Bertone-Johnson ER, Chocano-Bedoya PO, Zagarins SE, Micka AE, Ronnenberg AG. Dietary vitamin D intake, 25-hydroxyvitamin D3 levels and premenstrual syndrome in a college-aged population. J Steroid Biochem Mol Biol 2010;121:434-7. https://doi.org/10.1016/j.jsbmb.2010.03.076
  21. Chuong CJ, Dawson EB, Smith ER. Vitamin E levels in premenstrual syndrome. Am J Obstet Gynecol 1990;163:1591-5. https://doi.org/10.1016/0002-9378(90)90633-I
  22. Chocano-Bedoya PO, Manson JE, Hankinson SE, Johnson SR, Chasan- Taber L, Ronnenberg AG, et al. Intake of selected minerals and risk of premenstrual syndrome. Am J Epidemiol 2013;177:1118-27. https://doi.org/10.1093/aje/kws363
  23. Rapkin AJ, Akopians AL. Pathophysiology of premenstrual syndrome and premenstrual dysphoric disorder. Menopause Int 2012;18:52-9.
  24. Marjoribanks J, Brown J, O'Brien PM, Wyatt K. Selective serotonin reuptake inhibitors for premenstrual syndrome. Cochrane Database Syst Rev 2013;6:CD001396.
  25. Gupta R, Lahan V, Bansal S. Subjective sleep problems in young women suffering from premenstrual dysphoric disorder. N Am J Med Sci 2012;4:593-5. https://doi.org/10.4103/1947-2714.103326
  26. Klatzkin RR, Lindgren ME, Forneris CA, Girdler SS. Histories of major depression and premenstrual dysphoric disorder: Evidence for phenotypic differences. Biol Psychol 2010;84:235-47. https://doi.org/10.1016/j.biopsycho.2010.01.018
  27. Magnay JL, Ismail KM, Chapman G, Cioni L, Jones PW, O'Brien S. Serotonin transporter, tryptophan hydroxylase, and monoamine oxidase A gene polymorphisms in premenstrual dysphoric disorder. Am J Obstet Gynecol 2006;195:1254-9. https://doi.org/10.1016/j.ajog.2006.06.087
  28. Sylven SM, Ekselius L, Sundstrom-Poromaa I, Skalkidou A. Premenstrual syndrome and dysphoric disorder as risk factors for postpartum depression. Acta Obstet Gynecol Scand 2013;92:178-84. https://doi.org/10.1111/aogs.12041
  29. He Q, Xue G, Chen C, Lu ZL, Chen C, Lei X, et al. COMT Val158Met polymorphism interacts with stressful life events and parental warmth to influence decision making. Sci Rep 2012;2:677. https://doi.org/10.1038/srep00677
  30. Antypa N, Drago A, Serretti A. The role of COMT gene variants in depression: Bridging neuropsychological, behavioral and clinical phenotypes. Neurosci Biobehav Rev 2013;37:1597-610. https://doi.org/10.1016/j.neubiorev.2013.06.006
  31. Wang Y, Yang X. Association of catechol-o-methyltransferase polymorphism (Val108/158Met) with Parkinson's disease: a meta- analysis. J Mot Behav 2012;44:365-72. https://doi.org/10.1080/00222895.2012.721406
  32. Cordeiro Q, Silva RT, Vallada H. Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample. Arq Neuropsiquiatr 2012;70:913-6. https://doi.org/10.1590/S0004-282X2012001200002
  33. Okochi T, Ikeda M, Kishi T, Kawashima K, Kinoshita Y, Kitajima T, et al. Meta-analysis of association between genetic variants in COMT and schizophrenia: an update. Schizophr Res 2009;110:140-8. https://doi.org/10.1016/j.schres.2009.02.019
  34. Hartlage SA, Freels S, Gotman N, Yonkers K. Criteria for premenstrual dysphoric disorder: secondary analyses of relevant data sets. Arch Gen Psychiatry 2012;69:300-5. https://doi.org/10.1001/archgenpsychiatry.2011.1368
  35. Tjandrawinata RR, Nofiarny D, Susanto LW, Hendri P, Clarissa A. Symptomatic treatment of premenstrual syndrome and/or primary dysmenorrhea with DLBS1442, a bioactive extract of Phaleria macrocarpa. Int J Gen Med 2011;4:465-76.

Cited by

  1. Reproductive Affective Disorders: a Review of the Genetic Evidence for Premenstrual Dysphoric Disorder and Postpartum Depression vol.19, pp.12, 2014, https://doi.org/10.1007/s11920-017-0852-0