Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Molecular Links between Alcohol and Tobacco Induced DNA Damage, Gene Polymorphisms and Patho-physiological Consequences: A Systematic Review of Hepatic Carcinogenesis

  • Mansoori, Abdul Anvesh (Molecular Biology Laboratory, Department of Biotechnology, Dr. Hari Singh Gour Central University) ;
  • Jain, Subodh Kumar (Molecular Biology Laboratory, Department of Biotechnology, Dr. Hari Singh Gour Central University)
  • Published : 2015.07.13
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Abstract

Chronic alcohol and tobacco abuse plays a crucial role in the development of different liver associated disorders. Intake promotes the generation of reactive oxygen species within hepatic cells exposing their DNA to continuous oxidative stress which finally leads to DNA damage. However in response to such damage an entangled protective repair machinery comprising different repair proteins like ATM, ATR, H2AX, MRN complex becomes activated. Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma. There is increasing evidence that the inflammatory process is inherently associated with many different cancer types, including hepatocellular carcinomas. The generated reactive oxygen species can also activate or repress epigenetic elements such as chromatin remodeling, non-coding RNAs (micro-RNAs), DNA (de) methylation and histone modification that affect gene expression, hence leading to various disorders. The present review provides comprehensive knowledge of different molecular mechanisms involved in gene polymorphism and their possible association with alcohol and tobacco consumption. The article also showcases the necessity of identifying novel diagnostic biomarkers for early cancer risk assessment among alcohol and tobacco users.

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References

  1. Afshar M, Richards S, Mann D, et al (2015). Acute immunomodulatory effects of binge alcohol ingestion. Alcohol, 49, 57-64 https://doi.org/10.1016/j.alcohol.2014.10.002
  2. Al-Azri M, Al-Rasbi K, Al-Hinai M, et al (2014). Awareness of risk factors for cancer among Omani adults--a community based study. Asian Pac J Cancer Prev, 15, 5401-6 https://doi.org/10.7314/APJCP.2014.15.13.5401
  3. Anantharaman D, Chaubal PM, Kannan S, et al (2007). Susceptibility to oral cancer by genetic polymorphisms at CYP1A1, GSTM1 and GSTT1 loci among Indians: tobacco exposure as a risk modulator. Carcinogenesis, 28, 1455-62 https://doi.org/10.1093/carcin/bgm038
  4. Andrade BB, Hullsiek KH, Boulware DR, et al (2013) Biomarkers of inflammation and coagulation are associated with mortality and hepatitis flares in persons coinfected with HIV and hepatitis viruses. J Infect Dis, 207, 1379-88 https://doi.org/10.1093/infdis/jit033
  5. Areeshi MY (2013). Genetic variation in a DNA double strand break repair gene in saudi population: a comparative study with worldwide ethnic groups. Asian Pac J Cancer Prev, 14, 7091-4 https://doi.org/10.7314/APJCP.2013.14.12.7091
  6. Arora D, Marya CM, Menon I, et al (2015). Cross sectional survey on association between alcohol, betel- nut, cigarette consumption and health promoting behavior of industrial workers in Ghaziabad. Asian Pac J Cancer Prev, 16, 139-44 https://doi.org/10.7314/APJCP.2015.16.1.139
  7. Banerjee S, Chattopadhyay R, Ghosh A, et al (2008). Cellular and molecular mechanisms of cigarette smoke-induced lung damage and prevention by vitamin C. J Inflamm, 5, 21 https://doi.org/10.1186/1476-9255-5-21
  8. Bei CH, Bai H, Yu HP, et al (2014). Combined effects of six cytokine gene polymorphisms and SNP-SNP interactions on hepatocellular carcinoma risk in Southern Guangxi, China. Asian Pac J Cancer Prev, 15, 6961-7 https://doi.org/10.7314/APJCP.2014.15.16.6961
  9. Bennett WP, Alavanja MCR, Blomeke B, et al (1999). Environmental tobacco smoke, genetic susceptibility, and risk of lung cancer in never-smoking women. J Natl Cancer Inst, 91, 2009-14 https://doi.org/10.1093/jnci/91.23.2009
  10. Berkovich E, Monnat RJ, Kastan MB (2007). Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair. Nat Cell Biol, 9, 683-90 https://doi.org/10.1038/ncb1599
  11. Bhargava A, Mishra D, Banerjee S, et al (2012). Engineered dendritic cells for gastrointestinal tumor immunotherapy: opportunities in translational research. J Drug Target, 21, 126-36.
  12. Bortolami M, Kotsafti A, Cardin R, et al (2008). Fas / FasL system, IL-1beta expression and apoptosis in chronic HBV and HCV liver disease. J Viral Hepat, 15, 515-22 https://doi.org/10.1111/j.1365-2893.2008.00974.x
  13. Bray F, Ren JS, Masuyer E, et al (2012). Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Cancer, 2012, 1133-45
  14. Burim RV, Canalle R, Martinelli Ade L, et al (2004). Polymorphisms in glutathione S-transferases GSTM1, GSTT1 and GSTP1 and cytochromes P450 CYP2E1 and CYP1A1 and susceptibility to cirrhosis or pancreatitis in alcoholics. Mutagenesis, 19, 291-298 https://doi.org/10.1093/mutage/geh034
  15. Callen E, Di Virgilio M, Kruhlak MJ, et al (2013). 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell, 153, 1266-80 https://doi.org/10.1016/j.cell.2013.05.023
  16. Cao HX, Li SP, Wu JZ, et al (2010). Alcohol dehydrogenase-2 and aldehyde dehydrogenase-2 genotypes, alcohol drinking and the risk for stomach cancer in Chinese males. Asian Pac J Cancer Prev, 11, 1073-7
  17. Cen G, Wu W (2013). Association between tumor necrosis factor-alpha 857C/T polymorphism and gastric cancer: a meta-analysis. Tumour Biol, 34, 3383-8 https://doi.org/10.1007/s13277-013-0910-0
  18. Chadda P, Yadav, JS (2011). Studies on the Genotoxicity of Gutkha. Genet, 11, 277-82
  19. Charni M, Rivlin N, Molchadsky A, et al (2014). p53 in liver pathologies-taking the good with the bad. J Mol Med (Berl), 92, 1229-34 https://doi.org/10.1007/s00109-014-1223-5
  20. Chaudhary P, Sharma R, Sahu M, et al (2013). 4-Hydroxynonenal induces G2/M phase cell cycle arrest by activation of the ataxia telangiectasia mutated and Rad3-related protein (ATR)/checkpoint kinase 1 (Chk1) signaling pathway. J Biol Chem, 288, 20532-46 https://doi.org/10.1074/jbc.M113.467662
  21. Choi HS, Seo HS, Kim JH, et al (2012). Ethanol extract of Paeonia Suffruticosa Andrews (PSE) induced AGS human gastric cancer cell apoptosis via fas-dependent apoptosis and MDM2-p53 pathways. J Biomed Sci, 19, 82 https://doi.org/10.1186/1423-0127-19-82
  22. Choudhury M, Park PH, Jackson D, Shukla SD (2010). Evidence for the role of oxidative stress in the acetylation of histone H3 by ethanol in rat hepatocytes. Alcohol, 44, 531-40 https://doi.org/10.1016/j.alcohol.2010.06.003
  23. Choudhury M, Shukla SD (2008). Surrogate alcohols and their metabolites modify histone H3 acetylation: Involvement of histone acetyl transferase and histone deacetylase. Alcohol Clin Exp Res, 32, 829-39 https://doi.org/10.1111/j.1530-0277.2008.00630.x
  24. Chung HW, Lim JB (2015). Role of the tumor microenvironment in the pathogenesis of gastric carcinoma. World J Gastroenterol, 20, 1667-80
  25. Cichoz-Lach H, Celinski K, Wojcierowski J, et al (2010). Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men. Braz J Med Biol Res, 43, 257-61 https://doi.org/10.1590/S0100-879X2010007500006
  26. Coskun U, Bukan N, Sancak B, et al (2004). Serum hepatocyte growth factor and interleukin-6 levels can distinguish patients with primary or metastatic liver tumors from those with benign liver lesions. Neoplasma, 51, 209-13
  27. Cotton SC, Sharp L, Little J, et al (2000). Glutathione S-transferase polymorphisms and colorectal cancer: a HuGE review. Am J Epidemiol, 151, 7-32 https://doi.org/10.1093/oxfordjournals.aje.a010124
  28. Curtis BJ, Zahs A, Kovacs EJ (2013). Epigenetic targets for reversing immune defects caused by alcohol exposure. Alcohol Res, 35, 97-113
  29. da Silva NM, Germano FN, Vidales-Braz BM, et al (2015). Polymorphisms of IL-10 gene in patients infected with HCV under antiviral treatment in southern Brazil. Cytokine, 73, 253-257 https://doi.org/10.1016/j.cyto.2014.12.022
  30. Day JJ, Sweatt JD (2011). Review of Epigenetic Mechanisms in Cognition. Neuron, 70, 813-29 https://doi.org/10.1016/j.neuron.2011.05.019
  31. de Menezes RF, Bergmann A, Thuler LC (2013). Alcohol consumption and risk of cancer: a systematic literature review. Asian Pac J Cancer Prev, 14, 4965-72 https://doi.org/10.7314/APJCP.2013.14.9.4965
  32. Dunna NR, Vure S, Sailaja K, et al (2014). Deletion of GSTM1 and T1 genes as a risk factor for development of acute leukemia. Asian Pac J Cancer Prev, 14, 2221-4
  33. El-Serag HB, Rudolph KL (2007). Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterol, 132, 2557-76 https://doi.org/10.1053/j.gastro.2007.04.061
  34. El-Tayeh SF, Hussein TD, El-Houseini ME, et al (2012). Serological biomarkers of hepatocellular carcinoma in Egyptian patients. Disease Markers, 32, 255-63 https://doi.org/10.1155/2012/962320
  35. Eng MY, Luczak SE, Wall TL (2007). ALDH2, ADH1B and ADH1C Genotypes in Asians: A Literature Review. Alcohol Res Health, 30, 22-26
  36. Falck J, Coates J, Jackson SP (2005). Conserved modes of recruitment of ATM, ATR and NA-PKcs to sites of DNA damage. Nature, 434, 605-11 https://doi.org/10.1038/nature03442
  37. Farooqi AA, Attar R, Arslan BA, et al (2014). Recently emerging signaling landscape of Ataxia-telangiectasia mutated (ATM) kinase. Asian Pac J Cancer Prev, 15, 6485-8 https://doi.org/10.7314/APJCP.2014.15.16.6485
  38. Feil R, Fraga MF (2012). Epigenetics and the environment: Emerging patterns and implications. Nature Rev Genetics, 13, 97-109 https://doi.org/10.1038/nrg3142
  39. Ferlay J, Shin HR, Bray F, et al (2010). Cancer Incidence and Mortality Worldwide: IARC Cancer Base No. 10 [Internet]. Lyon, France: International Agency for Research on Cancer; 2010
  40. Fernandez-Capetillo O, Lee A, Nussenzweig M, et al (2004). H2AX: the histone guardian of the genome. DNA Repair (Amst), 3, 959-67 https://doi.org/10.1016/j.dnarep.2004.03.024
  41. Ferrari P, McKay JD, Jenab M, et al (2012). Alcohol dehydrogenase and aldehyde dehydrogenase gene polymorphisms, alcohol intake and the risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition study. Eur J Clin Nutr, 66, 1303-8 https://doi.org/10.1038/ejcn.2012.173
  42. Freed M, Afzal M, Siddique YH (2011). Micronucleus investigation in buccal mucosa cells among pan masala/gutkha chewers and its relevance for oral cancer. Bio Med, 3, 8-15
  43. Gajalakshmi V, Kanimozhi V (2015). Tobacco chewing and adult mortality: a case-control analysis of 22,000 cases and 429,000 controls, never smoking tobacco and never drinking alcohol, in South India. Asian Pac J Cancer Prev, 16, 1201-6 https://doi.org/10.7314/APJCP.2015.16.3.1201
  44. Gandhi G, Kaur R (2000) Cytogenetic studies in exfoliated cells of high cancer risk groups, pan masala chewers. Human Ecololgy Special Issue, 9, 221-8
  45. Gao B, Bataller R (2011). Alcoholic liver disease: pathogenesis and new therapeutic targets. Gastroenterol, 141, 1572-85 https://doi.org/10.1053/j.gastro.2011.09.002
  46. Gao J, Xie L, Yang WS, et al (2012). Risk factors of hepatocellular carcinoma--current status and perspectives. Asian Pac J Cancer Prev, 13, 743-52 https://doi.org/10.7314/APJCP.2012.13.3.743
  47. Gao M, Li Y, Xue X, et al (2014). Impact of AhR, CYP1A1 and GSTM1 genetic polymorphisms on TP53 R273G mutations in individuals exposed to polycyclic aromatic hydrocarbons. Asian Pac J Cancer Prev, 15, 2699-705 https://doi.org/10.7314/APJCP.2014.15.6.2699
  48. Gao Y, Cao Y, Tan A, et al (2010). Glutathione S-transferase M1 polymorphism and sporadic colorectal cancer risk: an updating Meta-analysis and HuGe Review of 36 case-control studies. Ann Epidemiol, 20, 108-121 https://doi.org/10.1016/j.annepidem.2009.10.003
  49. Goldar S, Khaniani MS, Derakhshan SM, Baradaran B (2015). Molecular mechanisms of apoptosis and roles in cancer development and treatment. Asian Pac J Cancer Prev, 16, 2129-44 https://doi.org/10.7314/APJCP.2015.16.6.2129
  50. Gubergrits NB, Kishenya MS, Golubova OA (2014). Polymorphism of ethanol metabolism genes in alcoholic chronic pancreatitis. Ter Arkh, 86, 49-55
  51. Guo Z, Pei S, Si T, et al (2015). Expression of the $\gamma$-phosphorylated histone H2AX in gastric carcinoma and gastric precancerous lesions. Oncol Lett, 9, 1790-94 https://doi.org/10.3892/ol.2015.2896
  52. Gupta RK, Patel AK, Shah N, et al (2014). Oxidative stress and antioxidants in disease and cancer: a review. Asian Pac J Cancer Prev, 15, 4405-9 https://doi.org/10.7314/APJCP.2014.15.11.4405
  53. Hamed MA, Ali SA (2013). Non-viral factors contributing to hepatocellular carcinoma. World J Hepatol, 5, 311-22 https://doi.org/10.4254/wjh.v5.i6.311
  54. Heit C, Dong H, Chen Y, et al (2015). Transgenic mouse models for alcohol metabolism, toxicity, and cancer. Adv Exp Med Biol, 815, 375-87 https://doi.org/10.1007/978-3-319-09614-8_22
  55. Hoeijmakers JH (2009). DNA damage, aging, and cancer. N Engl J Med, 361, 1475-85 https://doi.org/10.1056/NEJMra0804615
  56. Hsia CY, Huo TI, Chiang SY, et al (2007). Evaluation of interleukin-6, interleukin-10 and human hepatocyte growth factor as tumor markers for hepatocellular carcinoma. Eur J Surg Oncol, 33, 208-12 https://doi.org/10.1016/j.ejso.2006.10.036
  57. Hu JL, Hu SS, Hou XX, et al (2015). Abnormal expression of DNA double-strand breaks related genes, ATM and gammaH2AX, in thyroid carcinoma. Int J Endocrinol, 2015, 136810.
  58. IARC (2004) Monographs on the evaluation of the carcinogenic risks to humans, tobacco habits other than smoking; betel quid and areca nut chewing. Lyon: International Agency for Research on Cancer, 85
  59. Jemal A, Bray F, Center MM, et al (2011). Global cancer statistics. CA Cancer J Clin, 61, 69-90 https://doi.org/10.3322/caac.20107
  60. Jyoti S, Afzal M, Siddique YH (2011). Genotoxic effects of pan masala and gutkha: A review. World J Zool, 6, 301-6
  61. Kamo N, Ke B, Ghaffari AA, et al (2013). ASC/caspase-1/IL-$1{\beta}$ signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury. Hepatol, 58, 351-62 https://doi.org/10.1002/hep.26320
  62. Kang JY, Song SH, Yun J, et al (2015). Identification of long-range epigenetic silencing on chromosome 15q25 and its clinical implication in gastric cancer. Am J Pathol, 185, 666-78 https://doi.org/10.1016/j.ajpath.2014.11.022
  63. Kanwal F, Hoang T, Kramer JR, et al (2011) Increasing prevalence of HCC and cirrhosis in patients with chronic hepatitis C virus infection. Gastroenterol, 140, 1182-88 https://doi.org/10.1053/j.gastro.2010.12.032
  64. Kar P (2014) Risk factors for hepatocellular carcinoma in India. J Clin Exp Hepatol, 4, 34-42
  65. Karabi MM, Bhavna MB (2010) Tobacco and poverty research and capacity building: narrative report. organization: voluntary health association of India, New Delhi, India
  66. Kendrick SF, O'Boyle G, Mann J, et al (2010). Acetate, the key modulator of inflammatory responses in acute alcoholic hepatitis. Hepatol, 51, 1988-97 https://doi.org/10.1002/hep.23572
  67. Khanna A, Gautam DS, Gokhale M, Jain, S.K. (2014). Tobacco dust induced genotoxicity as an occupational hazard in workers of bidi making cottage industry of central India. Toxicology International, 21, 18-23
  68. Kirk GD, Bah E, Montesano R (2006). Molecular epidemiology of human liver cancer: insights into etiology, pathogenesis and prevention from The Gambia, West Africa. Carcinogenesis, 27, 2070-82 https://doi.org/10.1093/carcin/bgl060
  69. Kitaoka S, Shiota G, Kawasaki H (2003). Serum levels of interleukin-10, interleukin-12 and soluble interleukin-2 receptor in chronic liver disease type C. Hepatogastroenterol, 50, 1569-74
  70. Kiyohara C, Yamamura K, Nakanishi Y (2000). Polymorphism in GSTM1, GSTT1 and GSTP1 and susceptibility to lung cancer in a Japanese population. Asian Pac J Cancer Prev, 1, 293-8
  71. Koh WP, Robien K, Wang R, et al (2011). Smoking as an independent risk factor for hepatocellular carcinoma: the Singapore Chinese health study. Br J Cancer, 105, 1430-5 https://doi.org/10.1038/bjc.2011.360
  72. Kury S, Buecher B, Robiou-du-Pont S, et al (2007). Combinations of cytochrome P450 gene polymorphisms enhancing the risk for sporadic colorectal cancer related to red meat consumption. Cancer Epidemiol Biomarkers Prev, 16, 1460-67 https://doi.org/10.1158/1055-9965.EPI-07-0236
  73. Lakkakula S, Maram R, Munirajan AK, et al (2013). Functional PstI/RsaI polymorphisms in the CYP2E1 gene among south Indian populations. Asian Pac J Cancer Prev, 14, 179-82 https://doi.org/10.7314/APJCP.2013.14.1.179
  74. Langhans B, Kramer B, Louis M, et al (2013). Intrahepatic IL-8 producing $Foxp3^+CD4^+$ regulatory T cells and fibrogenesis in chronic hepatitis C. J Hepatol, 59, 229-35 https://doi.org/10.1016/j.jhep.2013.04.011
  75. Lavin MF (2007). ATM and the Mre11 complex combine to recognize and signal DNA double-strand breaks. Oncogene, 26, 7749-58 https://doi.org/10.1038/sj.onc.1210880
  76. Lavin MF, Kozlov S (2007). ATM activation and DNA damage response. Cell Cycle, 6, 931-42 https://doi.org/10.4161/cc.6.8.4180
  77. Lee HC., Lee HS, Jung SH, et al (2001). Association between polymorphisms of ethanol metabolizing enzymes and susceptibility to alcoholic cirrhosis in a Korean male population. J Korean Med Sci, 16, 745-50 https://doi.org/10.3346/jkms.2001.16.6.745
  78. Lee HE, Han N, Kim MA, et al (2014). DNA damage response-related proteins in gastric cancer: ATM, Chk2 and p53 expression and their prognostic value. Pathobiol, 81, 25-35 https://doi.org/10.1159/000351072
  79. Lee JH, Paull TT (2007). Activation and regulation of ATM kinase activity in response to DNA double-strand breaks. Oncogene, 26, 7741-48 https://doi.org/10.1038/sj.onc.1210872
  80. Lee KH, Koh SA, Kim JR (2013). Hepatocyte growth factor-mediated gastrin-releasing peptide induces IL-8 expression through Ets-1 in gastric cancer cells. Oncol Res, 20, 393-402
  81. Lee YC, Cohet C, Yang YC, et al (2009). Meta-analysis of epidemiologic studies on cigarette smoking and liver cancer. Int J Epidemiol, 38, 1497-511 https://doi.org/10.1093/ije/dyp280
  82. Liu K, Zhang L, Lin X, et al (2013). Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC) in Chinese population evaluated by an updated systematic meta-analysis. PLoS One, 8, e57043 https://doi.org/10.1371/journal.pone.0057043
  83. Lo CH, Chang CM, Tang SW, et al (2010). Differential antitumor effect of interleukin-12 family cytokines on orthotopic hepatocellular carcinoma. J Gene Med, 12, 423-34 https://doi.org/10.1002/jgm.1452
  84. Malakar M, Devi KR, Phukan RK, et al (2012). Genetic polymorphism of glutathione S-transferases M1 and T1, tobacco habits and risk of stomach cancer in Mizoram, India. Asian Pac J Cancer Prev, 13, 4725-32 https://doi.org/10.7314/APJCP.2012.13.9.4725
  85. Malakar M, Devi KR, Phukan RK, et al (2014). CYP2E1 genetic polymorphism with dietary, tobacco, alcohol habits, H. pylori infection status and susceptibility to stomach cancer in Mizoram, India. Asian Pac J Cancer Prev, 15, 8815-22 https://doi.org/10.7314/APJCP.2014.15.20.8815
  86. Malakar M, Devi KR, Phukan RK, et al (2014). p53 codon 72 polymorphism interactions with dietary and tobacco related habits and risk of stomach cancer in Mizoram, India. Asian Pac J Cancer Prev, 15, 717-23 https://doi.org/10.7314/APJCP.2014.15.2.717
  87. Mandrekar P, Szabo G (2009). Signalling pathways in alcohol-induced liver inflammation. J Hepatol, 50, 1258-66 https://doi.org/10.1016/j.jhep.2009.03.007
  88. Margaret AL, Syahruddin E, Wanandi SI (2011). Low activity of manganese superoxide dismutase (MnSOD) in blood of lung cancer patients with smoking history: relationship to oxidative stress. Asian Pac J Cancer Prev, 12, 3049-53
  89. Mirzoeva OK, Petrini JH (2001). DNA damage-dependent nuclear dynamics of the Mre11 complex. Mol Cell Biol, 21, 281-8 https://doi.org/10.1128/MCB.21.1.281-288.2001
  90. Munaka M, Kohshi K, Kawamoto T, et al (2003). Genetic polymorphisms of tobacco and alcohol-related metabolizing enzymes and the risk of hepatocellular carcinoma. J Cancer Res Clin Oncol, 129, 355-60 https://doi.org/10.1007/s00432-003-0439-5
  91. Niida H, Nakanishi M (2006). DNA damage checkpoints in mammals. Mutagenesis, 21, 3-9 https://doi.org/10.1093/mutage/gei063
  92. Nourazarian AR, Kangari P, Salmaninejad A (2014). Roles of oxidative stress in the development and progression of breast cancer. Asian Pac J Cancer Prev, 15, 4745-51 https://doi.org/10.7314/APJCP.2014.15.12.4745
  93. Ohashi E, Takeishi Y, Ueda S, Tsurimoto T (2014). Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage. DNA Repair (Amst), 21, 1-11 https://doi.org/10.1016/j.dnarep.2014.05.001
  94. Orsetti B, Selves J, Bascoul-Mollevi C, et al (2014). Impact of chromosomal instability on colorectal cancer progression and outcome. BMC Cancer, 14, 121 https://doi.org/10.1186/1471-2407-14-121
  95. Panda K, Chatterjee IB (2007). Failure of alpha-tocopherol to prevent cigarette smoke-induce protein oxidation: comparison with other antioxidant vitamins. victor r. editor, encyclopedia of vitamin E. Oxford University Press (CABI), Oxfordshire, UK. Preedy, King's College, London, UK. Chapter, 63, 883-93
  96. Park EJ, Lee JH, Yu GY, et al (2010). Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell, 140, 197-208 https://doi.org/10.1016/j.cell.2009.12.052
  97. Park S, Bae J, Nam BH, Yoo KY (2008). Aetiology of cancer in Asia. Asian Pac J Cancer Prev, 9, 371-80
  98. Patel BP, Trivedi PJ, Brahmbhatt MM, et al (2009). Micronuclei and chromosomal aberrations in healthy tobacco chewers and controls: A study from Gujrat, India. Arch of Oncol, 17, 1-2
  99. Poonam P, Khanna A, Jain SK (2010). Evaluation of genotoxicity in Bidi Rollers occupationally exposed to tobacco dust. National J Life Sci, 7, 89-93
  100. Poustchi H, Sepanlou SG, Esmaili S, Mehrabi N, Ansarymoghadam A (2010). Hepatocellular carcinoma in the world and the Middle East. Middle East J Diges Dis, 2, 31-41
  101. Purohit V, Rapaka R, Kwon OS, et al (2013). Roles of alcohol and tobacco exposure in the development of hepatocellular carcinoma. Life Sci, 92, 3-9 https://doi.org/10.1016/j.lfs.2012.10.009
  102. Rodier F, Campisi J, Bhaumik D (2007). Two faces of p53: aging and tumor suppression. Nucleic Acids Res, 35, 7475-84 https://doi.org/10.1093/nar/gkm744
  103. Rossini A, Rapozo DC, Soares Lima SC, et al (2007). Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population. Carcinogenesis, 28, 2537-42 https://doi.org/10.1093/carcin/bgm222
  104. Russo P, Cardinale A, Margaritora S, Cesario A (2012). Nicotinic receptor and tobacco-related cancer. Life Sci, 91, 1087-92 https://doi.org/10.1016/j.lfs.2012.05.003
  105. Seitz HK, Mueller S (2015). Alcohol and cancer: an overview with special emphasis on the role of acetaldehyde and cytochrome P450 2E1. Adv Exp Med Biol, 815, 59-70 https://doi.org/10.1007/978-3-319-09614-8_4
  106. Senthilkumar KP, Thirumurugan R (2012). Impact of tobacco on glutathione S transferase gene loci of Indian ethnics. Asian Pac J Cancer Prev, 13, 5037-42 https://doi.org/10.7314/APJCP.2012.13.10.5037
  107. Senthilkumar KP, Thirumurugan R (2012). Impact of tobacco on glutathione S transferase gene loci of Indian ethnics. Asian Pac J Cancer Prev, 13, 5037-42 https://doi.org/10.7314/APJCP.2012.13.10.5037
  108. Sharma A, Pandey A, Sardana S, Sehgal S, Sharma JK (2012). Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and Global populations. Asian Pac J Cancer Prev, 13, 5647-52 https://doi.org/10.7314/APJCP.2012.13.11.5647
  109. Sharma AK, Bhattacharya S, Khan SA, et al (2015). Dynamic alteration in H3 serine 10 phosphorylation is G1-phase specific during ionization radiation induced DNA damage response in human cells. Mutat Res, 773, 83-91 https://doi.org/10.1016/j.mrfmmm.2015.01.017
  110. Shen YH, Chen S, Peng YF, et al (2014). Quantitative assessment of the effect of glutathione S-transferase genes GSTM1 and GSTT1 on hepatocellular carcinoma risk. Tumour Biol, 35, 4007-15 https://doi.org/10.1007/s13277-013-1524-2
  111. Shiloh Y (2003). ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer, 3, 155-68 https://doi.org/10.1038/nrc1011
  112. Shiloh Y (2006). The ATM-mediated DNA-damage response: taking shape. Trends Biochem Sci, 31, 402-10 https://doi.org/10.1016/j.tibs.2006.05.004
  113. Shin A, Lee KM, Ahn B, et al (2008). Genotype-phenotype relationship between DNA repair gene genetic polymorphisms and DNA repair capacity. Asian Pac J Cancer Prev, 9, 501-5
  114. Shukla P, Khanna A, Jain SK (2011). Working condition: A key factor in increasing occupational hazard among bidi rollers: A population health research with respect to DNA damage. Indian J Occup Environ Med, 15, 139-41 https://doi.org/10.4103/0019-5278.93206
  115. Shukla SD, Aroor AR (2006). Epigenetic effects of ethanol on liver and gastrointestinal injury. World JGastroenterol, 12, 5265-71 https://doi.org/10.3748/wjg.v12.i33.5265
  116. Sobti RC, Al-Badran AI, Sharma S, et al (2005). Genetic polymorphisms of CYP2D6, GSTM1 and GSTT1 genes and bladder cancer risk in north India. Cancer Genet Cytogenet, 156, 68-73 https://doi.org/10.1016/j.cancergencyto.2004.04.001
  117. Stracker TH, Petrini JH (2011). The MRE11 complex: starting from the ends. Nat Rev Mol Cell Biol, 12, 90-103 https://doi.org/10.1038/nrm3047
  118. Su CH, Lin Y, Cai L (2013). Genetic factors, viral infection, other factors and liver cancer: an update on current progress. Asian Pac J Cancer Prev, 14, 4953-60 https://doi.org/10.7314/APJCP.2013.14.9.4953
  119. Sundaramoorthy R, Srinivasan V, Gujar J, et al (2013). Clinical, cytogenetic and CYP1A1 exon-1 gene mutation analysis of Beedi workers in Vellore region, Tamil Nadu. Asian Pac J Cancer Prev, 14, 7555-60 https://doi.org/10.7314/APJCP.2013.14.12.7555
  120. Talaat RM, Esmail AA, Elwakil R, Gurgis AA, Nasr MI (2012). Tumor necrosis factor-alpha -308G/A polymorphism and risk of hepatocellular carcinoma in hepatitis C virus-infected patients. Chin J Cancer, 31, 29-35
  121. Tong GX, Liang H, Chai J, et al (2014). Association of risk of gastric cancer and consumption of tobacco, alcohol and tea in the Chinese population. Asian Pac J Cancer Prev,15, 8765-74 https://doi.org/10.7314/APJCP.2014.15.20.8765
  122. Tung KH, Huang YS, Yang KC, et al (2010). Serum Interleukin-12 Levels in Alcoholic Liver Disease. J Chin Med Assoc, 73, 67-71 https://doi.org/10.1016/S1726-4901(10)70004-6
  123. Umadevi B, Swama M, Padmavathi P, Jyothi A, Reddy PP (2003). Cytogenetic effects in workers occupationally exposed to tobacco dust. Mutat Res, 535, 147-54 https://doi.org/10.1016/S1383-5718(02)00291-7
  124. Unsal-Kacmaz K, Sancar A (2004). Quaternary structure of ATR and effects of ATRIP and replication protein A on its DNA binding and kinase activities. Mol Cell Biol, 24, 1292-1300 https://doi.org/10.1128/MCB.24.3.1292-1300.2003
  125. Uziel T, Lerenthal Y, Moyal L, (2003). Requirement of the MRN complex for ATM activation by DNA damage. EMBO J, 22, 5612-21 https://doi.org/10.1093/emboj/cdg541
  126. Vettriselvi V, Vijayalakshmi K, Paul SD, Venkatachalam P (2006). Genetic variation of GSTM1, GSTT1 and GSTP1 genes in a South Indian population. Asian Pac J Cancer Prev, 7, 325-28
  127. Vijayalakshmi K, Vettriselvi V, Krishnan M, et al (2005). Polymorphisms at GSTM1 and GSTP1 gene loci and risk of prostate cancer in a South Indian population. Asian Pac J Cancer Prev, 6, 309-14
  128. Wang HJ, Gao B, Zakhari S, et al (2012). Inflammation in alcoholic liver disease. Annu Rev Nutr, 32, 343-68 https://doi.org/10.1146/annurev-nutr-072610-145138
  129. WHO (2014). Global status report on alcohol and health 2014. Publication Data. 2014
  130. Wu CS, Ouyang J, Mori E, et al (2014). SUMOylation of ATRIP potentiates DNA damage signaling by boosting multiple protein interactions in the ATR pathway. Genes Dev, 28, 1472-84 https://doi.org/10.1101/gad.238535.114
  131. Yamada I, Matsuyama M, Ozaka M, et al (2014). Lack of associations between genetic polymorphisms in GSTM1, GSTT1 and GSTP1 and pancreatic cancer risk: a multi-institutional case-control study in Japan. Asian Pac J Cancer Prev, 15, 391-5 https://doi.org/10.7314/APJCP.2014.15.1.391
  132. Yamashita H, Kaneyuki T, Tagawa K (2001). Production of acetate in the liver and its utilization in peripheral tissues. Biochimica et Biophysica Acta, 1532, 79-87 https://doi.org/10.1016/S1388-1981(01)00117-2
  133. Yao J, Qian CJ, Ye B, et al (2014). Signal transducer and activator of transcription 3 signaling upregulates fascin via nuclear factor-${\kappa}B$ in gastric cancer: Implications in cell invasion and migration. Oncol Lett, 7, 902-8 https://doi.org/10.3892/ol.2014.1804
  134. Ye YN, Liu ES, Shin VY, et al (2004). The modulating role of nuclear factor-kappa B in the action of alpha7-nicotinic acetylcholine receptor and cross-talk between 5- lipoxygenase and yclooxygenase-2 in colon cancer growth induced by 4-(N-methyl-N-nitrosamino)-1- (3-pyridyl)-1-butanone. J Pharmacol Exp Ther, 311, 123-30 https://doi.org/10.1124/jpet.104.068031
  135. Yin Y, Si X, Gao Y, et al (2013). The nuclear factor-${\kappa}B$ correlates with increased expression of interleukin-6 and promotes progression of gastric carcinoma. Oncol Rep, 29, 34-8 https://doi.org/10.3892/or.2012.2089
  136. Yu BW, Zhang LQ, Teng XL, et al (2015). Association between the CYP1A1 polymorphisms and hepatocellular carcinoma: a meta-analysis. Genet Mol Res, 14, 1076-84 https://doi.org/10.4238/2015.February.6.11
  137. Yu L, Sun L, Jiang YF, et al (2012). Interactions between CYP1A1 polymorphisms and cigarette smoking are associated with the risk of hepatocellular carcinoma: evidence from epidemiological studies. Mol Biol Rep, 39, 6641-6 https://doi.org/10.1007/s11033-012-1469-3
  138. Zakhari S (2013). Bermuda Triangle for the liver: Alcohol, obesity, and viral hepatitis. J Gastroenterol Hepatol, 28, 18-25
  139. Zhang FF, Hou L, Terry et al (2007). Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland. Int J Cancer, 121, 2060-64 https://doi.org/10.1002/ijc.22973
  140. Zhang L, Ding Y, Yuan Z, et al (2015). MicroRNA-500 sustains nuclear factor-${\kappa}B$ activation and induces gastric cancer cell proliferation and resistance to apoptosis. Oncotarget, 6, 2483-95 https://doi.org/10.18632/oncotarget.2800
  141. Zhu B, Wang C, Zhang X, et al (2015). Relationships between interleukin-12B and interleukin-10 gene polymorphisms and hepatitis C in Chinese Han hemodialysis patients. Ren Fail, 37, 505-10. https://doi.org/10.3109/0886022X.2015.1006086
  142. Zygogianni A, Kyrgias G, Mystakidou K, et al (2011). Potential role of the alcohol and smoking in the squamous cell carcinoma of the head and neck: review of the current literature and new perspectives. Asian Pac J Cancer Prev, 12, 339-44

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