Review on the study of Gyejibokryeong-hwan - Had been published in Korea from 1990 to 2014 -

계지복령환의 실험적 연구 및 치험례, 임상연구에 대한 고찰 (1990년부터 2014년까지 발행된 국내 학술지를 중심으로)

  • Jung, Hoon (Dept. of Rehabilitation Medicine, College of Korean Medicine, DaeJeon University) ;
  • Kim, So-Yun (Dept. of Rehabilitation Medicine, College of Korean Medicine, DaeJeon University) ;
  • Park, Jung-Oh (Dept. of Acupuncture & Moxibustion, College of Korean Medicine, DaeJeon University) ;
  • Lee, Eun-Jung (Dept. of Rehabilitation Medicine, College of Korean Medicine, DaeJeon University) ;
  • Oh, Min-Seok (Dept. of Rehabilitation Medicine, College of Korean Medicine, DaeJeon University)
  • Received : 2015.06.29
  • Accepted : 2015.08.17
  • Published : 2015.08.20

Abstract

Objective : The aim of this review is to analyze the study tendency in papers on Gyejibokryeong-hwan had been published in Korea from 1990 to 2014. Methods : We searched the four electronic database(NSDL, RISS, Korean traditional knowledge portal, OASIS) and checked relevant Korean journals from 1990 to 2014. We classified the papers by publication date, speciality, study method, and field of study, and analysed the study tendency. Results : After analyzing the papers, these results are revealed : 1. 2.12 papers were published annually on average. 2. As for the speciality of the journal, most of the papers were published in Traditional Korean Medicine, and a few were in Pharmacology. 3. As for the study method, in vitro was 32%, in vivo was 30%, and clinical case was 21%, 4. As for the subject of the studies, beneficial effect was 86%, toxicity was 8%, safety, stability and qualitative analysis was 2% each. 5. As for the studies about effectiveness on the diseases, 30% at gynecologic disease and 30% at vascular disease like arteriosclerosis. There were new studies for a variety of fields like cancer, urologic, and musculoskeletal diseases. Conclusions : These results suggest that Gyejibokryeong-hwan can be used as cure medicine, but there are not sufficient evidence based papers, so there should be further studies in order to establish Gyejibokryeong-hwan as a cure medicine.

Keywords

References

  1. Yates JS, MUstian KM, Morrow GR, gilies LJ, Padmanaban D, Atkins JN, Issell B, Kirshner JJ, Colman LK. Prevalence of complementary and alternative medicine use in cancer patients during treatment. Support Care Cancer 2005;13(10):806-11. https://doi.org/10.1007/s00520-004-0770-7
  2. Cui Y, Shu XO, Gao Y, Wen W, Ruan ZX, Jin F, Zheng W. Use of complementary and alternative medicine by chinese women with breast cancer. Breast Cancer Res Treat. 2004;85(3):263-70. https://doi.org/10.1023/B:BREA.0000025422.26148.8d
  3. Kang SS. concept of blood stasis in Oriental medicine. Journal of Korean Medicine.1984;5:138-140.
  4. Chen CZ. Chinese medicine treatment and prescription. 4th edition. Beijing :People health publication. 2003:417.
  5. Oriental medical college herbal botany professors. Herbal botany. Seoul. Younglim publication. 1991;124-5, 193-5, 302-4, 423-4, 581-3.
  6. Nam EJ, Lee YK, Lee DN and Kim HJ. Clinical study on the effect of Gyebongnyeong capsule in the treatment of primary dysmenorrhea. Korean J. Oriental Physiology & Pathology. 2006;20(5):1364-8.
  7. Xie SP, Feng YM. On the discussion on Geijibokryunghwan article. Henan Traditional Chinese Medicine. 1994;14(2):73-4.
  8. Song W, Kim DW, Yoon, TJ, Kim SH. Study on Antitumor Activity, Antimetastatic Effects Kejibokyounghwankamibang, Korean J. Oriental Physiology & Pathology. 2001;15(1):36-41.
  9. Lee SK, Kim HG, Ahan JC, Chung, TW, Moon JY, Park SD, Kim JK, Choi DY, Kim CH and Park WH. Effect of the Geijibokryunghwan on human hepatocarcinoma cells. Korean J. Oriental Physiology & Pathology. 2003;17(2):568-73.
  10. Hwang DS, Cho JH, Jang JB and Lee KS. Inhibitory effects of Gaejibokryunghwan on cell proliferation in HeLa cells. J. Korean Oriental Med. 2006;27(1):23-35.
  11. Yao Z, Shulan Z. Inhibition effect of Guizhi-Fuling-decoction on the invasion of human cervical cancer. J. Ethnopharmacol. 2008;120(1):25-35. https://doi.org/10.1016/j.jep.2008.07.044
  12. Ha DJ, Jeong KJ and Lee KN. Effect of Kaejibokryungwhan on analgesic, anti-inflammation, anti-convulsion, muscle relaxation and changes of body temperature through experimental animal. J. Korean Oriental Med. 1995;16(1):339-50.
  13. Park WH, Joo ST, Park KK, Chang YC and Kim CH. Effects of the Geiji-Bokryung-Hwan on carrageenan-induced inflammation in mice and cyclooxygenase-2 in hepatoma cells of HeG2 and Hep3B. Immunopharmacol. Immunotoxicol. 2004;26(1):103-12. https://doi.org/10.1081/IPH-120029948
  14. Yi IH, Lee KS and Song BK. Effect of Guizibokryungwhan aqua-acupuncture on the intravascular coag-ulation induced by endotoxin in rats. The J. of Oriental Gynecology. 2000;13(1):1-17.
  15. Choi MH. Park WH. Effect of the Geijibokryunghwan water extracts on stimulus-induced superoxide generation and tyrosyl phosphorylation in human neutrophils. Korean J. Oriental Physiol. Pathol. 2006;20(2):477-81.
  16. Kim BJ, Kim YK, Park WH, Ko JH, Lee YC and Kim CH. A water-extract of the Korean traditional formulation Geiji-Bokryung-Hwan reduces atherosclerosis and hypercholesteremia in cholesterol-fed rabbits. Int. Immunopharmacol. 2003;3(5):723-34. https://doi.org/10.1016/S1567-5769(03)00073-0
  17. Park WH, Kim KS, Kim KH, Kim DS and Kim CH. The antiplatelet activity of Geiji-Bokryung-Hwan, Korean traditional formulation, is mediated through inhibition of phospholipase C and inhibition of TxB2 synthetase activity. Int. Immunopharmacol. 2003;3(7):971-8. https://doi.org/10.1016/S1567-5769(03)00095-X
  18. Nakagawa T, Goto H, Hikiami H, Yokozawa T, Shibahara N and Shimada Y. Protective effects of keishibukuryogan on the kidney of spontaneously diabetic WBN/Kob rats. J. Ethnopharmacol. 2007;110(2):311-7. https://doi.org/10.1016/j.jep.2006.09.043
  19. Gao S. Geijibokryunghwan treated prostatic hypertrophy. Zhejiang Journal of Traditional Chinese Medicine. 1983;11:493.
  20. Chen DS, Chen XY, Nie X. Geijibokryunghwan treated Pelvic congestion syndrome for 32 clinical cases. New Journal of Traditional Chinese Medicine. 1991;23(6):31-4.
  21. Li YX. New usage of Geijibokryunghwan. New Journal of Traditional Chinese Medicine. 2001;33(1):70.
  22. Jo HG, Park AR, Kee YB, Kang DH, Choi JB and Sil JU. A clinical trial on the blood stasis and efficacy of Kyejibokryong-whan(Guizhifuling-wan) in the patients with motor vehicle accident. J. Oriental Rehab Med. 2011;21(3):45-55.
  23. Cho JH. A pilot study of the difference between Gyejibongnyeong-hwan and Gyejibongnyeong-hwan combined acupuncture therapy on the primary dysmenorrhea. The J. of Oriental Obstetrics & Gynecology. 2007;20(1):161-8.
  24. Park JM, Yang JM and Kim DI. A clinical trial to verity the quality of life imporvement efficacy of Dangguijakyak-san and Gyejibongnyeong-hwan granulation in postmenopausal women. The J. of Oriental Obstetrics & Gynecology. 2007;20(3):213-28.
  25. Cho KH, Kim YS, Jung WS and Kim TH. Effect of Gui-zhi-fu-ling-wan on hot flashes in young patients: A retrospective case series. Journal of Acupuncture Meridian Study. 2011;4(2):129-33. https://doi.org/10.1016/S2005-2901(11)60019-8
  26. Yea SJ, Jang HC, Kim JH, Kim C, Kim SK, Song MY. Design of models for the Korean Traditional Medicine research trend analysis system. The Journal of the Korea Contents Association. 2009;9(12):711-7.
  27. Lee HY, Cho KJ, Kang HS, Shin HS. Research Trend of Oriental Nursing in Korea. Journal of East-West nursing research. 2003;8(1):27-40.
  28. Lee YJ, Hwang DS, Lee CH, Lee KS. A Review of the Study on Complementary and Alternative Medicine in Obstetrics. Journal of Korean Oriental Medicine. 2009;30(1):137-49.
  29. Lee SJ. Research Trends on the Effect of Sagunzatang and Samultang. Journal of Daejeon University Oriental Medicine Institute. 2011;20(1):175-82.
  30. Oriental medical college herbal medicine professors. Herbal medicine. Seoul. Younglim publication. 2009;409
  31. Zhang J. Zhongjing collection. Taipei:Jipmoon publication. 1972;172-3, 228, 236
  32. Shi YR. Gynecology of traditional Chinese medicine. Hongkong, Qianqingtang publication. 1959;58, 71
  33. Mary R. Marginal to Mainstram Alternative medicine in America. Cambridge university press, 2004;43.
  34. Takegawa Y, Ikushima H, Ozaki K, Furutani S, Kawanaka T, Kudoh T, Harada M. Can Kampo therapy prolong the life of cancer patient? Jornal Medical Investment. 2008;99-105.
  35. Kim HS, Choi JE, Yoo HS. The Effectiveness of Gargling Hwangryunhaedok-tang on Chemotherapy-Induced Stomatitis. Journal of Korean traditional oncology. 2011;16(1):1-14.
  36. Song KK, Kwak MA, Kim JD. Anticancer and Related Immunomodulatory Effects of Insamyangyoung-tang on Non-small Cell Lung Carcinoma, NCI-H520, Xenograft Mice. Herbal formula science. 2013;21(5):51-70. https://doi.org/10.14374/HFS.2013.21.1.051
  37. Lee JH, Yoo DY. Meta Analysis of researches about herbal extracts used in breast cancer in South Korea since 2000. Journal of Daejeon University Oriental Medicine Institute. 2007;16(2):241-9.
  38. Park SC, Yoo HS, Cho CK, Lee YW. Recent Experimental Tendency for Herbal Medicines Treating Lung Cancer in South Korea. Journal of Korean traditional oncology. 2008;13(1):43-54.
  39. Seo MJ, Lee KB, Park JH, Hong SH. The Current Trend of Research about Bojungikki-tang. Korean journal of oriental medicine. 2010;16(2):83-90.
  40. Park SJ, Kang KR, Kim SA, Hwang SM, Chae H. Systematic Review on the Study of Sasang Typology Published in Korea from 2000 to 2009. Korean journal of oriental physiology & pathology. 2011;25(4):721-7.
  41. Jung H, Park SJ, Lee HY, Kim B, Lee EJ, Oh MS, Heo DS. Review on the Study of Sibjeondaebo-tang (Shiquan dabutang) Published in Korea from 2000 to 2013. Journal of Oriental Rehabilitation Medicine. 2014;24(1):47-53.
  42. Seo CS, Kim OS, Shin HK. Quantitative Analysis and Antioxidant Effects of Gyejibokryeong-hwan. Journal of Pharmacogn. 2014;45(3):240-8.
  43. Park JH, Lee YJ, Park HJ. Stability of Cinnamadehyde and Cinnamic acid of Cinnamomi Cortex Preparations. Journal of Pharmacogn. 2006;37(1):53-5.
  44. Kim JH, Yoo YS, Mang MH, Yun HS. Effects of Some Comnined Crude Drug Preparations aganist Platelet Aggregations. Journal of Pharmacogn. 1990;21(2):126-9.
  45. Kim SB, Paudel KR, Kim DW. Preventive Effect of Traditional Korean Formulations on Intimal Thickening of Rat Carotid Artery Injured by Balloon Catheter. Korean journal of plant resources. 2013;26(2):678-85. https://doi.org/10.7732/kjpr.2013.26.6.678