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만형자 용매 분획물의 미백 개선 효과

Whitening Effects of Solvent Fractions Isolated from Vitex rotundifolia

  • Yu, Jae-Myo (Korea Promotion Institute for Traditional Medicine Industry) ;
  • Kim, Dong-Hee (Korea Promotion Institute for Traditional Medicine Industry) ;
  • Son, Jun-Ho (Korea Promotion Institute for Traditional Medicine Industry)
  • 투고 : 2015.06.11
  • 심사 : 2015.07.17
  • 발행 : 2015.09.30

초록

최근에는 hyper-pigmentation에 대한 제품 개발을 위해 melanogenesis의 경로에 대한 이해를 위해 많은 노력을 하고 있다. 이에 따라 본 연구에서는 만형자(Vitex rotundifolia)의 depigmentation에 대한 효과를 조사하였다. B16F10 mouse melanoma cell을 이용하여 tyrosinase, MITF, TRP-1, TRP-2 그리고 melanin synthesis의 저해를 확인하였고, 만형자 ethyl acetate 분획물(VR-EA)을 처리하였을 때 농도의존적으로 감소한다는 것을 알 수 있었다. 특히, VR-EA는 tyrosinase와 TRP-1의 경우 각각 53.2, 88.4%의 저해율을 보여 미백에 있어서 효과적인 활성을 보여주었다. 따라서 만형자는 melanin synthesis를 효과적으로 막아주어 미백소재로서 활용 가능성이 충분하다고 사료된다.

Recently many effort focused to understand the mechanical insights of melanogenesis to develop the agent for hyper-pigmentation. So this study was performed to investigate the depigmentation of Vitex rotundifolia. With B16F10 mouse melanoma cell, we have seen inhibition of the tyrosinase, MITF, TRP-1, TRP-2, and melanin synthesis, which eventually were dose dependently decreased by Vitex rotundifolia. Specially, Vitex rotundifolia decreased the protein levels of tyrosinase and TRP-1. In conclusion, Vitex rotundifolia showed the whitening activity in all the experiments mentioned above and we expect that it can be used for preventing melanin synthesis.

키워드

참고문헌

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피인용 문헌

  1. Efficacy of Cosmetic Materials Using Aronia melanocarpa Leaf Extracts vol.16, pp.2, 2015, https://doi.org/10.20402/ajbc.2017.0166
  2. B16F10 melanoma cell을 이용한 캐모마일(Matricaria chamomilla L.) 추출물의 미백 효과 vol.61, pp.3, 2015, https://doi.org/10.3839/jabc.2018.038
  3. 말오줌나무 추출물의 미백활성 검증 vol.29, pp.3, 2015, https://doi.org/10.5352/jls.2019.29.3.279