Journal of the Society of Cosmetic Scientists of Korea (대한화장품학회지)

Society of Cosmetic Scientists of Korea (대한화장품학회)
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Anti-inflammatory Effect of Fallopia sachalinensis RonseDecr. Fruit

왕호장 열매의 항염증 효과

  • Park, Sung Ha (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Jeong, Jeong Hyeon (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Park, Byoung Jun (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center) ;
  • Jeong, Tae Hwa (Bio Materials R&D Center, Kolmar Korea, CBTP, Future Convergent Tech Center)
  • Received : 2015.06.17
  • Accepted : 2015.08.18
  • Published : 2015.09.30
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Abstract

To develop a new anti-inflammation agent for cosmetics, we investigated the anti-inflammatory activity of Fallopia sachalinensis RonseDecr. fruit extracts (FSR). FSR inhibited the pre-inflammatory cytokines ($1L-1{\beta}$, IL-6, TNF-${\alpha}$) and reduced NO production of RAW 264.7 macrophage cells in a dose-dependent manner and decreased the activity to about 51% at a concentration of $100{\mu}g/mL$. FSR suppressed not only the mRNA expression of iNOS and COX-2, but also the protein expression of iNOS and COX-2 in macrophage. The results suggested that FSR has considerable potential as a cosmetics ingredient with an anti-inflammatory effect.

본 연구에서는 왕호장 열매 추출물(FSR)의 항염증 효과를 측정하였다. 왕호장 열매 추출물은 RAW 264.7 macrophage 세포에서 염증 사이토카인($1L-1{\beta}$, IL-6, TNF-${\alpha}$)의 발현을 억제하였으며, 농도 의존적으로 NO 생성을 억제하고, 그 효과는 $100{\mu}g/mL$ 농도에서 51%로 나타났다. 뿐만 아니라, iNOS와 COX-2의 mRNA와 단백질 발현을 모두 억제함을 확인하였다. 따라서 왕호장 열매 추출물은 항염증 효능을 갖는 화장품 소재로서의 개발 가능성이 클 것으로 기대된다.

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References

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