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Biologically active compounds from natural and marine natural organisms with antituberculosis, antimalarial, leishmaniasis, trypanosomiasis, anthelmintic, antibacterial, antifungal, antiprotozoal, and antiviral activities

  • Received : 2014.04.08
  • Accepted : 2016.11.15
  • Published : 2016.11.30

Abstract

The biologically active compounds derived from different natural organisms such as animals, plants, and microorganisms like algae, fungi, bacteria and merine organisms. These natural compounds possess diverse biological activities like anthelmintic, antibacterial, antifungal, antimalarial, antiprotozoal, antituberculosis, and antiviral activities. These biological active compounds were acted by variety of molecular targets and thus may potentially contribute to several pharmacological classes. The synthesis of natural products and their analogues provides effect of structural modifications on the parent compounds which may be useful in the discovery of potential new drug molecules with different biological activities. Natural organisms have developed complex chemical defense systems by repelling or killing predators, such as insects, microorganisms, animals etc. These defense systems have the ability to produce large numbers of diverse compounds which can be used as new drugs. Thus, research on natural products for novel therapeutic agents with broad spectrum activities and will continue to provide important new drug molecules.

Keywords

References

  1. Akilov OE, Khachemoune A, Hasan, T. Clinical manifestations and classification of Old World cutaneous leishmaniasis. Int J Dermatol. 2007;46;132-142. https://doi.org/10.1111/j.1365-4632.2007.03154.x
  2. Aneiros A, Garateix A. Bioactive peptides from marine sources: pharmacological properties and isolation procedures. J Chromatogr B: Analyt Technol Biomed Life Sci. 2004;803:41-53. https://doi.org/10.1016/j.jchromb.2003.11.005
  3. Ankisetty S, Amsler CD, McClintock JB, Baker BJ. Further Membranolide Diterpenes from the Antarctic Sponge Dendrilla membranosa. J Nat Prod. 2004;67:1172-1174. https://doi.org/10.1021/np0340551
  4. Aoki S, Wei H, Matsui K, Rachmat R, Kobayashi M. Pyridoacridine alkaloids inducing neuronal differentiation in a neuroblastoma cell line, from marine sponge Biemna fortis. Bioorg Med Chem. 2003;11:1969-1973. https://doi.org/10.1016/S0968-0896(03)00086-5
  5. Ata A, Win HY, Holt D, Holloway P, Segstro EP, Jayatilake GS. New antibacterial diterpenes from Pseudopterogorgia elisabethae. Helv Chim Acta. 2004; 87:1090-1098. https://doi.org/10.1002/hlca.200490099
  6. Bernan VS, Greenstein M, Carter GT. Mining marine microorganisms as a source of new antimicrobials and antifungals. Curr Med Chem Anti-Infect Agents. 2004;3:181-195. https://doi.org/10.2174/1568012043353883
  7. Boelaert M, Le Ray D, Van der Stuyft P. How better drugs could change kala-azar control. Lessons from a cost-effectiveness analysis. Trop Med Int Health. 2002;7:955-959. https://doi.org/10.1046/j.1365-3156.2002.00959.x
  8. Boulahbal F, Heifets L. Bacteriology of Tuberculosis. Reichman and Hershfield's Tuberculosis. 3rd (Part A) ed. Raviglione MC ed. (New York, USA: Informa Healthcare USA Inc.), 2006;219:29-47.
  9. Breman J. The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg. 2001;64:1. https://doi.org/10.4269/ajtmh.2001.64.1
  10. Bugni TS, Singh MP, Chen L, Arias DA, Harper MK, Greenstein M, Maiese WM, Concepcion GP, Mangalindan GC, Ireland CM. Kalihinols from two Acanthella cavernosa sponges: Inhibitors of bacterial folate biosynthesis. Tetrahedron. 2004;60:6981-6988. https://doi.org/10.1016/j.tet.2003.08.082
  11. Buss AD, Waigh RD. Natural Products as Leads for New Pharmaceuticals. Burger's Medicinal Chemistry and Drug Discovery, Volume 1: Principals and Practice. 15thed. Wolff ME ed. (New York, USA: Wiley), pp. 983-1034, 1995.
  12. Butler MS. Natural products to drugs: natural product derived compounds in clinical trials. Nat Prod Rep. 2005;22:162-195. https://doi.org/10.1039/b402985m
  13. Capon RJ, Skene C, Liu EH, Lacey E, Gill JH, Heiland K, Friedel T. Nematocidal thiocyanatins from a southern Australian marine sponge, Oceanapia sp. J Nat Prod. 2004;67: 1277-1282. https://doi.org/10.1021/np049977y
  14. Chagas Disease Fact Sheet. http://www.cdc.gov/parasites/az/index.html#c (accessed on 26th June 2007).
  15. Chang L, Whittaker NF, Bewley CA. Crambescidin 826 and dehydrocrambine A: New polycyclic guanidine alkaloids from the marine sponge Monanchora sp. That inhibit HIV-1 fusion. J Nat Prod. 2003;66;1490-1494. https://doi.org/10.1021/np030256t
  16. Chill L, Rudi A, Aknin M, Loya S, Hizi A, Kashman Y. New sesterterpenes from Madagascan Lendenfeldia sponges. Tetrahedron. 2004;60:10619-10626. https://doi.org/10.1016/j.tet.2004.09.022
  17. Chin YW, Balunas MJ, Chai HB, Kinghorn AD. Drug discovery from natural sources. APPS Journal. 2006;8:E239-E253.
  18. Cho SH, Warit S, Wan B, Hwang CH, Pauli GF, Franzblau SG. Low-oxygen-recovery assay for high-throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2007;51:1380-1385. https://doi.org/10.1128/AAC.00055-06
  19. Coker HAB, Chukwuanim CM, Ifudu ND, Aina BA. The Malaria. Scourge. Concepts in Disease Management. The Nig J Pharm. 2000;32:19- 47.
  20. Copp BR, Pearce AN. Natural product growth inhibitors of Mycobacterium tuberculosis. Nat Prod Rep. 2007;24:278-297. https://doi.org/10.1039/B513520F
  21. Copp BR. Antimycobacterial natural products. Nat Prod Rep. 2003;20:535-557. https://doi.org/10.1039/b212154a
  22. Cragg GM, Kingston DGI, Newman DJ. Introduction. AnticancerAgents from Natural Products. Cragg GM, Kingston DGI, Newman DJ eds. (Boca Raton, USA: Taylor & Francis), pp. 1-3, 2005.
  23. De Oliveira JH, Grube A, Kock M, Berlinck RG, Macedo ML, Ferreira AG, Hajdu E. Ingenamine G and cyclostellettamines G-I, K, and L from the new Brazilian species of marine sponge Pachychalina sp. J Nat Prod. 2004;67:1685-1689. https://doi.org/10.1021/np0498713
  24. Desjeux P, Alvar J. Leishmania/HIV co-infections: epidemiology in Europe. Ann Trop Med Parasitol. 200;97:3-15. https://doi.org/10.1179/000349803225002499
  25. Dmitrenok AS, Radhika P, Anjaneyulu V, Subrahmanyam S, Rao PVS, Dmitrenok PS, Boguslavsky VM. New lipids from the soft corals of the Andaman Islands. Russ Chem Bull. 2003;52:1868-1872. https://doi.org/10.1023/A:1026089612129
  26. Donaghy L, Gros F, Amiot L, Mary C, Maillard A, Guiguen C, Gangneux JP. Elevated levels of soluble non-classical major histocompatibility class I molecule human leucocyte antigen (HLA)-G in the blood of HIV-infected patients with or without visceral leishmaniasis. Clin Exp Immunol. 2007;147:236-240.
  27. Donia M, Hamann MT. Marine natural products and their potential applications as anti-infective agents. Lancet Infect Dis. 2003;3:338-348. https://doi.org/10.1016/S1473-3099(03)00655-8
  28. Edwards DJ, Marquez BL, Nogle LM, McPhail K, Goeger DE, Roberts MA, Gerwick WH. Structure and biosynthesis of the jamaicamides, new mixed polyketide-peptide neurotoxins from the marine cyanobacterium Lyngbya majuscula. Chem Biol. 2004;11:817-833. https://doi.org/10.1016/j.chembiol.2004.03.030
  29. Ekthawatchai S, Isaka M, Kittakoop P, Kongsaeree P, Sirichaiwat C, Tanticharoen M, Tanchompoo B, Thebtaranonth Y, Yuthavong Y. Synthetic and naturally occurring antimalarials. J Heterocyclic Chem. 1999;36:1599-1605. https://doi.org/10.1002/jhet.5570360621
  30. Endo T, Tsuda M, Okada T, Mitsuhashi S, Shima H, Kikuchi K, Mikami Y, Fromont J, Kobayashi J. Nagelamides A-H, new dimeric bromopyrrole alkaloids from marine sponge Agelas species. J Nat Prod. 2004;67:1262-1267. https://doi.org/10.1021/np034077n
  31. Erdogan-Orhan I, Sener B, De Rosa S, Perez-Baz J, Lozach O, Leost M, Rakhilin S, Meijer L. Polyprenyl-hydroquinones and -furans from three marine sponges inhibit the cell cycle regulating phosphatase CDC25A. Nat Prod Res. 2004;18:1-9. https://doi.org/10.1080/1478641031000111534
  32. Fennell BJ, Carolan S, Pettit GR, Bell A. Effects of the antimitotic natural product dolastatin 10, and related peptides, on the human malarial parasite Plasmodium falciparum. J Antimicrob Chemother. 2003;51:833-841. https://doi.org/10.1093/jac/dkg151
  33. Fernandez-Busquets X, Burger MM. Circular proteoglycans from sponges: first members of the spongican family. Cell Mol Life Sci. 2003;60:88-112. https://doi.org/10.1007/s000180300006
  34. Fotie J, Nkkengfack AE, Rukunga G, Tolo F, Peter MG, Heydenreich M, Fomum ZT. In-vivo antimalarial activity of some oxygenated xanthones. Ann Trop Med Parasitol. 2003;97:683-688. https://doi.org/10.1179/000349803225002390
  35. Frenz JL, Kohl AC, Kerr RG. Marine natural products as therapeutic agents: Part 2. Exp Opin Therap. Patents. 2004;14;17-33. https://doi.org/10.1517/13543776.14.1.17
  36. Fujita M, Nakao Y, Matsunaga S, Seiki M, Itoh Y, Yamashita J, van Soest RW, Fusetani N. Ageladine A: an antiangiogenic matrixmetalloproteinase inhibitor from the marine sponge Agelas nakamurai. J Am Chem Soc. 2003;125;15700-15701. https://doi.org/10.1021/ja038025w
  37. Fujita M, Nakao Y, Matsunaga S, van Soest RW, Itoh Y, Seiki M, Fusetani N. Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata. J Nat Prod. 2003;66:569-571. https://doi.org/10.1021/np020572s
  38. Gessler MC, Nkunya MHH, Mwasumbi LB, Heinrick M, Tanner M. Screening Tanzanian medicinal plants for antimalarial activity. Acta Tropica. 1994;56: 65-77. https://doi.org/10.1016/0001-706X(94)90041-8
  39. Go ML. Novel antiplasmodial agents. Med Res Rev. 2003;23:456-487. https://doi.org/10.1002/med.10040
  40. Gochfeld DJ, El Sayed KA, Yousaf M, Hu JF, Bartyzel P, Dunbar DC, Wilkins SP, Zjawiony JK, Schinazi RF, Schlueter WS, Tharnish PM, Hamann MT. Marine natural products as lead anti-HIV agents. Mini Rev Med Chem. 2003;3:401-424. https://doi.org/10.2174/1389557033487962
  41. Golenser J, Waknine JH, Krugliak M, Hunt NH, Grau GE. Current perspectives on the mechanism of action of artemisinins. Int J Parasitol. 2006;36;1427-1441. https://doi.org/10.1016/j.ijpara.2006.07.011
  42. Gompel M, Leost M, Kier Joffe EB, Puricelli L, Franco LH, Palermo J, Meijer L. Meridianins, a new family of protein kinase inhibitors isolated from the ascidian Aplidium meridianum. Bioorg Med Chem Lett. 2004;14:1703-1707. https://doi.org/10.1016/j.bmcl.2004.01.050
  43. Goud TV, Reddy NS, Swamy NR, Ram TS, Venkateswarlu Y. Anti-HIV active petrosins from the marine sponge Petrosia similis. Biol Pharm Bull. 2003;26:1498-1501. https://doi.org/10.1248/bpb.26.1498
  44. Goud TV, Srinivasulu M, Reddy VL, Reddy AV, Rao TP, Kumar DS, Murty US, Venkateswarlu Y. Two new bromotyrosine-derived metabolites from the sponge Psammaplysilla purpurea. Chem. Pharm. Bull (Tokyo). 2003;51: 990-993. https://doi.org/10.1248/cpb.51.990
  45. Grant MA, Morelli XJ, Rigby AC. Conotoxins and Structural Biology: A Prospective Paradigm for Drug Discovery. Curr Prot Pept Sci. 2004; 5:235-248. https://doi.org/10.2174/1389203043379710
  46. Griffith KS, Lewis LS, Mali S, Parise ME. Treatment of malaria in the United States: a systematic review. JAMA. 2007;297: 2264-2277. https://doi.org/10.1001/jama.297.20.2264
  47. Gu QJ, Graf NT, Lee D, Chai BH, Mi Q, Kardono BL, Setyowati MF, Ismail R, Riswan S, Farnsworth RN, Cordell AG, Pezzuto MJ, Swanson MS, Kroll JD, Falkinham OJ, Wall EM, Wani CM, Kinghorn DA, Oberlies HN. Cytotoxic and Antimicrobial Constituents of the Bark of Diospyros maritima Collected in Two Geographical Locations in Indonesia. J Nat Prod. 2004;67:1156-1161. https://doi.org/10.1021/np040027m
  48. Gunasekera SP, Sotheeswaran S, Sultanbawa US. Two new xanthones, calozeyloxanthone and zeyloxanthonone, from Calophyllum zeylanicum(Guttiferae). J Chem Soc, Perkin Transactions. 1981;1:1831-1835.
  49. Gustafson KR, Oku N, Milanowski DJ. Antiviral marine natural products. Curr Med Chem. 2004;3:233-249.
  50. Hassan W, Edrada R, Ebel R, Wray V, Berg A,Van Soest R,Wiryowidagdo S, Proksch P. New Imidazole Alkaloids from the Indonesian Sponge Leucetta chagosensis. J Nat Prod. 2004;67:817-822. https://doi.org/10.1021/np0305223
  51. Hay A-E, Aumond MC, Mallet S, Dumontet V, Litaudon M, Rondeau D, Richomme P. Antioxidant xanthones from Garcinia vieillardii. J Nat Prod. 2004; 67:707-709. https://doi.org/10.1021/np0304971
  52. Hay A-E, Guilet D, Morel C, Larcher G, Macherel D, Le Ray A-M, Litaudon M, Richomme P. Antifungal chromans inhibiting the mitochondrial respiratory chain of pea seeds and new xanthones from Calophyllum caledonicum. Planta Med. 2003;69:1130-1135. https://doi.org/10.1055/s-2003-818004
  53. Hay AE, Helesbeux JJ, Duval O, Red ML, Grellierb P, Richomme P. Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii. Life Sci. 2004;75:3077-3085. https://doi.org/10.1016/j.lfs.2004.07.009
  54. Haynes RK, Fugmann B, Stetter J, Rieckmann K, Heilmann HD, Chan H-W, Cheung M-K, Lam W-L, Wong H-N, Croft SL, Vivas L, Rattray L, Stewart L, Peters W, Robinson BL, Edstein MD, Kotecka B, Kyle DE, Beckermann B, Gerisch M, Radtke M, Schmuck G, Steinke W, Wollborn U, Schmeer K, Romer A. Artemisone--a highly active antimalarial drug of the artemisinin class. Angew Chem Int Ed. 2006;45:2082-2088. https://doi.org/10.1002/anie.200503071
  55. Haynes RK. From artemisinin to new artemisinin antimalarials: biosynthesis, extraction, old and new derivatives, stereochemistry and medicinal chemistry requirements. Curr Top Med Chem. 2006;6:509-537. https://doi.org/10.2174/156802606776743129
  56. Helesbeux JJ, Duval O, Dartiguelongue C, Seraphin D, Oger JM, Richomme P. Synthesis of 2-hydroxy-3-methylbut-3-enyl substituted coumarins and xanthones as natural products. Application of the Schenck ene reaction of singlet oxygen with ortho-prenylphenol precursors. Tetrahedron. 2004;60;2293-2300. https://doi.org/10.1016/j.tet.2004.01.033
  57. Hirono M, Ojika M, Mimura H, Nakanishi Y, Maeshima M. Acylspermidine derivatives isolated from a soft coral, Sinularia sp, inhibit plant vacuolar H(+)-pyrophosphatase. J Biochem. 2003;133:811-816. https://doi.org/10.1093/jb/mvg103
  58. Hong S, Kim SH, Rhee MH, Kim AR, Jung JH, Chun T, Yoo ES, Cho JY. In vitro anti-inflammatory and pro-aggregative effects of a lipid compound, petrocortyne A, from marine sponges. Naunyn-Schmiedeberg's Arch Pharmacol. 2003;368:448-456. https://doi.org/10.1007/s00210-003-0848-7
  59. Hu J, Geng M, Li J, Xin X,Wang J, Tang M, Zhang J, Zhang X, Ding J. Acidic oligosaccharide sugar chain, a marine-derived acidic oligosaccharide, inhibits the cytotoxicity and aggregation of amyloid beta protein. J Pharm Sci. 2004;95:248-255. https://doi.org/10.1254/jphs.FPJ04004X
  60. Ignatuschenko MV, Winter RW, Bachinger HP, Hinrichs DJ, Riscoe MK. Xanthones as antimalarial agents; studies of a possible mode of action. FEBS Lett. 1997;409:67-73. https://doi.org/10.1016/S0014-5793(97)00405-5
  61. Iijima R, Kisugi J, Yamazaki M. A novel antimicrobial peptide from the sea hare Dolabella auricularia. Dev Comp Immunol. 2003;27:305-311. https://doi.org/10.1016/S0145-305X(02)00105-2
  62. Iinuma M, Tosa H, Tanaka T, Yonemori S. Two xanthones from root bark of Calophyllum inophyllum. Phytochem. 1994;35:527-532. https://doi.org/10.1016/S0031-9422(00)94795-2
  63. Isnansetyo A, Kamei Y. MC21-A, a Bactericidal Antibiotic Produced by a New Marine Bacterium, Pseudoalteromonas phenolica sp. nov. O-BC30T, against Methicillin-Resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 2003;47:480-488. https://doi.org/10.1128/AAC.47.2.480-488.2003
  64. Ito C, Miyamoto Y, Rao KS, Furukawa H. A Novel Dibenzofuran and Two New Xanthones form Calophyllum panciflorum. Chem & Pharm Bull. 1996;44:441-443. https://doi.org/10.1248/cpb.44.441
  65. Iwasa K, Nishiyama Y, Ichimaru M, Moriyasu M, Kim H-S, Wataya Y, Yamori T, Takashi T, Lee D-U. Structure-activity relationships of quaternary protoberberine alkaloids having an antimalarial activity. Eur J Med Chem. 1999;34:1077-1083. https://doi.org/10.1016/S0223-5234(99)00127-0
  66. Jacob MR, Hossain CF, Mohammed KA, Smillie TJ, Clark AM, Walker LA, Nagle DG. Reversal of fluconazole resistance in multidrug efflux-resistant fungi by the Dysidea arenaria sponge sterol 9alpha,11alpha-epoxycholest-7-ene-3beta, 5alpha, 6alpha, 19-tetrol 6-acetate. J Nat Prod. 2003;66:1618-1622. https://doi.org/10.1021/np030317n
  67. Janin YL. Antituberculosis drugs: ten years of research. Bioorg Med Chem. 2007;15:2479-2513. https://doi.org/10.1016/j.bmc.2007.01.030
  68. Jiang YH, Ryu SH, Ahn EY, You S, Lee BJ, Jung JH, Kim DK. Antioxidant activity of (8E,13Z,20Z)-Strobilinin/(7E,13Z,20Z)-Felixinin from a Marine Sponge Psammocinia sp. Nat Prod Sci. 2004;10:272-276.
  69. Jung M, Kim H, Lee K, Park M. Naturally occurring peroxides with biological activities. Mini Rev Med Chem. 2003;3;159-165. https://doi.org/10.2174/1389557033405313
  70. Kamei Y, Tsang CK. Sargaquinoic acid promotes neurite outgrowth via protein kinase A and MAP kinases-mediated signaling pathways in PC12D cells. Int J Dev Neurosci. 2003;21:255-262. https://doi.org/10.1016/S0736-5748(03)00068-6
  71. Kaneko M, Kisa F, Yamada K, Miyamoto T, Higuchi R. Structure of a New Neuritogenic-Active Ganglioside from the Sea Cucumber Stichopus japonicus. Eur J Org Chem. 2003;2003:1004-1008. https://doi.org/10.1002/ejoc.200390141
  72. Kehraus S, Gorzalka S, Hallmen C, Iqbal J, Muller CE, Wright AD, Wiese M, Konig GM. Novel amino acid derived natural products from the ascidian Atriolum robustum: identification and pharmacological characterization of a unique adenosine derivative. J Med Chem. 2004;47:2243-2255. https://doi.org/10.1021/jm031092g
  73. Keyzers RA, Davies-Coleman MT. Anti-inflammatory metabolites from marine sponges. Chem Soc Rev. 2005;34;355-365. https://doi.org/10.1039/b408600g
  74. Keyzers RA, Northcote PT, Berridge MV. Clathriol B, a new 14 beta marine sterol from the New Zealand sponge Clathria lissosclera. Aust J Chem. 2003;56:279-282. https://doi.org/10.1071/CH02167
  75. Keyzers RA, Northcote PT, Zubkov OA. Novel anti-inflammatory Spongian Diterpenes from the New Zealand Marine Sponge Chelonaplysilla violacea. Eur J Org Chem. 2004;2004:419-425. https://doi.org/10.1002/ejoc.200300551
  76. Kobayashi M, Mahmud T, Yoshioka N, Shibuya H, Kitagawa I. Indonesian medicinal plants. XXI. Inhibitors of $Na^+/H^+$ exchanger from the bark of Erythrina variegate and the roots of Maclura cochinchinensis. Chem & Pharm Bull. 1997;45:1615-1619. https://doi.org/10.1248/cpb.45.1615
  77. Kossuga MH, MacMillan JB, Rogers EW, Molinski TF, Nascimento GG, Rocha RM, Berlinck RG. (2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. J Nat Prod. 2004;67:1879-1881. https://doi.org/10.1021/np049782q
  78. Kouam TNM, Lavaud C, Massiot G, Nuzillard MJ, Connolly DJ, Rycroft SD. Bipendensin, an unusual phenolic acetal from Afzelia bipendensis. Nat Prod Lett. 1993;3:299-303. https://doi.org/10.1080/10575639308043880
  79. Krishnaiah P, Reddy VL, Venkataramana G, Ravinder K, Srinivasulu M, Raju TV, Ravikumar K, Chandrasekar D, Ramakrishna S, Venkateswarlu Y. New lamellarin alkaloids from the Indian ascidian Didemnum obscurum and their antioxidant properties. J Nat Prod. 2004;67;1168-1171. https://doi.org/10.1021/np030503t
  80. Kuo YH, Chang CI, Li YS, Chou JC, Chen FC, Kuo YH, Lee KH. Cytotoxic constituents from the stems of Diospyros maritima. Planta Med. 1997;63:363-365. https://doi.org/10.1055/s-2006-957703
  81. Lakshmi V, Kumar R, Gupta P, Varshney V, Srivastava MN, Dikshit M, Murthy PK, Misra-Bhattacharya S. The antifilarial activity of a marine red alga, Botryocladia leptopoda, against experimental infections with animal and human filariae. Parasitol Res. 2004;93:468-474.
  82. Laurent D, Pietra F. Natural-product diversity of the New Caledonian marine ecosystem compared to other ecosystems: a pharmacologically oriented view. Chem Biodiv. 2004;1:539-594. https://doi.org/10.1002/cbdv.200490048
  83. Lee EH, Yun MR, Wang WH, Jung JH, Im DS. Structure-activity relationship of lysophosphatidylcholines in HL-60 human leukemia cells. Acta Pharmacol Sin. 2004;25:1521-1524.
  84. Likhitwitayawuid K, Dej-adisai S, Jongbunprasert V, Krungkrai J. Antimalarials from Stephania venosa, Prismatomeris sessiliflora, Diospyros montana and Murraya siamensis. Planta Med. 1999;65:754-756. https://doi.org/10.1055/s-2006-960858
  85. Lim SS, Kim HS, Lee DU. In vitro antimalarial activity of flavonoids and chalcones. Bull Korean Chem Soc. 2007;28:2495-2497. https://doi.org/10.5012/bkcs.2007.28.12.2495
  86. Lippert H, Brinkmeyer R, Mulhaupt T, Iken K. Antimicrobial activity in sub-Arctic marine invertebrates. Polar Biol. 2003;26:591-600. https://doi.org/10.1007/s00300-003-0525-9
  87. Liu J, Ren HP. Tuberculosis: Current Treatment and New Drug Development. Anti-Infective Agents in Med Chem. 2006;5:331-344. https://doi.org/10.2174/187152106778520433
  88. Livett BG, Gayler KR, Khalil Z. Drugs from the sea: conopeptides as potential therapeutics. Curr Med Chem. 2004;11:1715-1723. https://doi.org/10.2174/0929867043364928
  89. Lucas R, Casapullo A, Ciasullo L, Gomez-Paloma L, Paya M. Cycloamphilectenes, a new type of potent marine diterpenes: inhibition of nitric oxide production in murine macrophages. Life Sci. 2003a;72:2543-2552. https://doi.org/10.1016/S0024-3205(03)00167-X
  90. Lucas R, Giannini C, D'Auria MV, Paya M. Modulatory effect of bolinaquinone, a marine sesquiterpenoid, on acute and chronic inflammatory processes. J Pharmacol Exp Ther. 2003b;304:1172-1180.
  91. Luescher-Mattli M. Anti-infective Agents. Curr Med Chem. 2003;2:219-225.
  92. Lukes J, Mauricio IL, Schoenian G, Dujardin J-C, Soteriadou K, Dedet JP, Kuhls K, Tintaya KW, Jirku M, Chocholova E, Haralambous C, Pratlong F, Oborník M, Horak A, Ayala FJ, Miles MA. Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy. Proc Natl Acad Sci USA.2007;104:9375-9380. https://doi.org/10.1073/pnas.0703678104
  93. Luque-Ortega JR, Rivas L. Miltefosine (hexadecylphosphocholine) inhibits cytochrome c oxidase in Leishmania donovani promastigotes. Antimicrob Agents Chemother. 2007;51;1327-1332. https://doi.org/10.1128/AAC.01415-06
  94. Marrero J, Rodriguez AD, Baran P, Raptis RG, Sanchez JA,Ortega-Barria E, Capson TL. Bielschowskysin, a gorgonian-derived biologically active diterpene with an unprecedented carbon skeleton. Org Lett. 2004;6:1661-1664. https://doi.org/10.1021/ol049495d
  95. Masaba SC. The antimalarial activity of Vernonia amygdalina Del (Compositae). Trans Roy Soc Trop Med Hyg. 2000;94:694- 695. https://doi.org/10.1016/S0035-9203(00)90236-0
  96. Maskey RP, Helmke E, Kayser O, Fiebig HH, Maier A, Busche A, Laatsch H. Anti-cancer and antibacterial trioxacarcins with high anti-malaria activity from a marine Streptomycete and their absolute stereochemistry. J Antibiot. 2004;57:771-779. https://doi.org/10.7164/antibiotics.57.771
  97. Masuno MN, Hoepker AC, Pessah IN, Molinski TF. Relationship between body mass index and anti-hypertensive efficacy of doxazosin according to a survey of Japanese patients. Mar Drugs. 2004;2:176-184. https://doi.org/10.3390/md204176
  98. Matsubara K. Recent advances in marine algal anticoagulants. Curr Med Chem. 2004;2:13-19.
  99. Mayer AMS, Hamann MT. Marine pharmacology in 1999: compounds with antibacterial, anticoagulant, antifungal, anthelmintic, anti-inflammatory, antiplatelet, antiprotozoal and antiviral activities affecting the cardiovascular, endocrine, immune and nervous systems, and other miscellaneous mechanisms of action. Comp Biochem Physiol C Toxicol Pharmacol. 2002;132:315-339. https://doi.org/10.1016/S1532-0456(02)00094-7
  100. Mayer AMS, Hamann MT. Marine pharmacology in 2000: marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, antimalarial, antiplatelet, antituberculosis, and antiviral activities; affecting the cardiovascular, immune, and nervous systems and other miscellaneous mechanisms of action. Mar Biotechnol (NY) 2004;6:37-52. https://doi.org/10.1007/s10126-003-0007-7
  101. Mayer AMS, Hamann MT. Marine pharmacology in 2001-2002: Marine compounds with anthelmintic, antibacterial, anticoagulant, antidiabetic, antifungal, anti-inflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems and other miscellaneous mechanisms of action. Comp Biochem Physiol Part C Pharmacol Toxicol. 2004;140:265-286.
  102. Mayer AMS, Lehmann VKB. Marine pharmacology in 1998: Marine compounds with antibacterial, anticoagulant, antifungal, anti-inflammatory, anthelmintic, antiplatelet, antiprotozoal, and antiviral activities; with actions on the cardiovascular, endocrine, immune, and nervous systems; and other miscellaneous mechanisms of action. Pharmacologist. 2000;42:62-69.
  103. Mayer AMS, Rodríguez AD, Berlinck RGS, Hamann MT. Marine pharmacology in 2003-4: marine compounds with anthelmintic antibacterial, anticoagulant, antifungal, antiinflammatory, antimalarial, antiplatelet, antiprotozoal, antituberculosis, and antiviral activities; affecting the cardiovascular, immune and nervous systems, and other miscellaneous mechanisms of action. Compa Biochem Physiol C Toxicol Pharmacol. 2007;145:553-581. https://doi.org/10.1016/j.cbpc.2007.01.015
  104. McClelland D, Evans RM, Abidin I, Sharma S, Choudhry FZ, Jaspars M, Sepcic K, Scott RH. Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai. Br J Pharmacol. 2003;139:1399-1408. https://doi.org/10.1038/sj.bjp.0705374
  105. Meiyu G, Fuchuan L, Xianliang X, Jing L, Zuowei Y, Huashi G. The potential molecular targets of marine sulfated polymannuroguluronate interfering with HIV-1 entry. Interaction between SPMG and HIV-1 rgp120 and CD4 molecule. Antivir Res. 2003;59;127-135. https://doi.org/10.1016/S0166-3542(03)00068-8
  106. Melo FR, Pereira MS, Foguel D, Mourao PA. Antithrombin-mediated anticoagulant activity of sulfated polysaccharides: different mechanisms for heparin and sulfated galactans. J Biol Chem. 2004;279:20824-20835. https://doi.org/10.1074/jbc.M308688200
  107. Mendis K, Sina B, Marchesini P, Carter R. The neglected burden of Plasmodium vivax malaria. Am J Trop Med Hyg. 2001;64:97. https://doi.org/10.4269/ajtmh.2001.64.97
  108. Miao B, Geng M, Li J, Li F, Chen H, Guan H, Ding J. Sulfated polymannuroguluronate, a novel anti-acquired immune deficiency syndrome (AIDS) drug candidate, targeting CD4 in lymphocytes. Biochem Pharmacol. 2004;68:641-649. https://doi.org/10.1016/j.bcp.2004.04.009
  109. Miljanich GP. Ziconotide: neuronal calcium channel blocker for treating severe chronic pain. Curr Med Chem. 2004;11:3029-3040. https://doi.org/10.2174/0929867043363884
  110. Minami H, Takahashi E, Fukuyama Y, Kodama M, Yoshizawa TNK. Novel xanthones with superoxide scavenging activity from Garcinia subelliptica. Chem Pharm Bull. 1995;43:347-349. https://doi.org/10.1248/cpb.43.347
  111. Molinski TF. Anti-Infect. Agents. Curr Med Chem. 2004;3:197-220.
  112. Monti MC, Casapullo A, Riccio R, Gomez-Paloma L. Further insights on the structural aspects of PLA(2) inhibition by gamma-hydroxybutenolide-containing natural products: a comparative study on petrosaspongiolides M-R. Bioorg Med Chem. 2004;12:1467-1474. https://doi.org/10.1016/j.bmc.2003.12.038
  113. Morel C, Seraphin D, Oger JM, Litaudon M, Sevenet T, Richomme P, Bruneton J. New xanthones from Calophyllum caledonicum. J Nat Prod. 2000;63;1471-1474. https://doi.org/10.1021/np000215m
  114. Morel C, Seraphin D, Teyrouz A, Larcher G, Bouchara JP, Litaudon M, Richomme P, Bruneton J. New and antifungal xanthones from Calophyllum caledonicum. Planta Medica. 2002;68:41-44. https://doi.org/10.1055/s-2002-19867
  115. Mourao PA. Use of sulfated fucans as anticoagulant and antithrombotic agents: future perspectives. Curr Pharm Des. 2004;10;967-981. https://doi.org/10.2174/1381612043452730
  116. Mukku VJ, Edrada RA, Schmitz FJ, Shanks MK, Chaudhuri B, Fabbro D. New sesquiterpene quinols from a Micronesian sponge, Aka sp. J Nat Prod. 2003;66:686-689. https://doi.org/10.1021/np0205506
  117. Nakao Y, Maki T, Matsunaga S, van Soest RW, Fusetani N. Penasulfate A, a new alpha-glucosidase inhibitor from a marine sponge Penares sp. J Nat Prod. 2004b;67:1346-1350. https://doi.org/10.1021/np049939e
  118. Nakao Y, Shiroiwa T, Murayama S, Matsunaga S, Goto Y, Matsumoto Y, Fusetani N. Identification of Renieramycin A as an Antileishmanial Substance in a Marine Sponge Neopetrosia sp. Mar Drugs. 2004;2:55-62. https://doi.org/10.3390/md202055
  119. Namikoshi M, Suzuki S, Meguro S, Nagai H, Koike Y, Kitazawa A, Kobayashi H, Oda T, Yamada J. Manoalide derivatives from a marine sponge Luffariella sp. collected in Palau. Fish Sci. 2004;70:152-158.
  120. Newman DJ, Cragg GM, Snader KM. Natural products as sources of new drugs over the period 1981-2002. J Nat Prod. 2003;66:1022-1037. https://doi.org/10.1021/np030096l
  121. Newman DJ, Cragg GM. Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007;70;461-477. https://doi.org/10.1021/np068054v
  122. Nicholas GM, Eckman LL, Newton GL, Fahey RC, Ray S, Bewley CA. Inhibition and kinetics of mycobacterium tuberculosis and mycobacterium smegmatis mycothiol-S-conjugate amidase by natural product inhibitors. Bioorg Med Chem. 2003;11:601-608. https://doi.org/10.1016/S0968-0896(02)00345-0
  123. Nika K, Mulloy B, Carpenter B, Gibbs R. Specific recognition of immune cytokines by sulphated polysaccharides from marine algae. Eur J Phycol. 2003;38:257-264. https://doi.org/10.1080/0967026031000136367
  124. Nishimura S, Matsunaga S, Shibazaki M, Suzuki K, Furihata K, van Soest RW, Fusetani N. Massadine, a novel geranylgeranyltransferase type I inhibitor from the marine sponge Stylissa aff. massa. Org Lett. 2003;5:2255-2257. https://doi.org/10.1021/ol034564u
  125. Oger JM, Morel C, Helesbeux JJ, Litaudon M, Seraphin D, Dartiguelongue C, Larcher G, Richomme P, Duval O. First 2-hydroxy-3-methylbut-3-enyl substituted xanthones isolated from plants: structure elucidation, synthesis and antifungal activity. Nat Prod Res. 2003;17:195-199. https://doi.org/10.1080/1057563021000040808
  126. Ohgami K, Shiratori K, Kotake S, Nishida T, Mizuki N, Yazawa K, Ohno S. Effects of astaxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Invest Ophthalmol Visual Sci. 2003;44:2694-2701. https://doi.org/10.1167/iovs.02-0822
  127. Oku N, Gustafson KR, Cartner LK, Wilson JA, Shigematsu N, Hess S, Pannell LK, Boyd MR, McMahon JB. Neamphamide A, a new HIV-inhibitory depsipeptide from the Papua New Guinea marine sponge Neamphius huxleyi. J Nat Prod. 2004;67:1407-1411. https://doi.org/10.1021/np040003f
  128. Opsenica D, Kyle DE, Milhous WK, Olaja BA. Antimalarial, antimycobacterial and antiproliferative activity of phenyl substituted mixed tetraoxanes. J Serb Chem Soc. 2003;68:291-302. https://doi.org/10.2298/JSC0305291O
  129. Ospina CA, Rodriguez AD, Ortega-Barria E, Capson TL. Briarellins J-P and polyanthellin A: new eunicellin-based diterpenes from the gorgonian coral Briareum polyanthes and their antimalarial activity. J Nat Prod. 2003;66:357-363. https://doi.org/10.1021/np0204500
  130. Ovchinnikova TV, Aleshina GM, Balandin SV, Krasnosdembskaya AD, Markelov ML, Frolova EI, Leonova YF, Tagaev AA, Krasnodembsky EG, Kokryakov VN. Purification and primary structure of two isoforms of arenicin, a novel antimicrobial peptide from marine polychaeta Arenicola marina. FEBS Lett. 2004;577:209-214. https://doi.org/10.1016/j.febslet.2004.10.012
  131. Oyewole IO, Ibidapo CA, Moronkola DO, Oduola AO, Adeoye GO, Anyasor GN, Obansa JA. Anti-malarial and repellent activities of Tithonia diversifolia (Hemsl.) leaf extracts. J Med Plants Res. 2008;2:171-175.
  132. Pan W, Liu X, Ge F, Han J, Zheng T. Perinerin, a novel antimicrobial peptide purified from the clamworm Perinereis aibuhitensis grube and its partial characterization. J Biochem. 2004;135:297-304. https://doi.org/10.1093/jb/mvh036
  133. Pascual I, Gil-Parrado S, Cisneros M, Joseph-Bravo P, Diaz J, Possani LD, Charli JL, Chavez M. Purification of a specific inhibitor of pyroglutamyl aminopeptidase II from the marine annelide Hermodice carunculata. in vivo effects in rodent brain. Int J Biochem Cell Biol. 2004;36:138-152. https://doi.org/10.1016/S1357-2725(03)00175-4
  134. Paterson I, Anderson EA. Chemistry. The renaissance of natural products as drug candidates. Science. 2005;310:451-453. https://doi.org/10.1126/science.1116364
  135. Patrzykat A, Douglas SE. Gone gene fishing: how to catch novel marine antimicrobials. Trends Biotechnol. 2003;21:362-369. https://doi.org/10.1016/S0167-7799(03)00145-8
  136. Patrzykat A, Gallant JW, Seo JK, Pytyck J, Douglas SE. Novel antimicrobial peptides derived from flatfish genes. Antimicrob Agents Chemother. 2003;47:2464-2470. https://doi.org/10.1128/AAC.47.8.2464-2470.2003
  137. Pereira HS, Leao-Ferreira LR, Moussatché N, Teixeira VL, Cavalcanti DN, Costa LJ, Diaz R, Frugulhetti IC. Antiviral activity of diterpenes isolated from the Brazilian marine alga Dictyota menstrualis against human immunodeficiency virus type 1 (HIV-1). Antivir Res. 2004;64:69-76.
  138. Perez M, Sadqi M, Munoz V, Avila J. Inhibition by Aplidine of the aggregation of the prion peptide PrP 106-126 into beta-sheet fibrils. Biochim Biophys Acta. 2003;1639:133-139. https://doi.org/10.1016/j.bbadis.2003.08.003
  139. Pettit RK, Fakoury BR, Knight JC, Weber CA, Pettit GR, Cage GD, Pon S. Antibacterial activity of the marine sponge constituent cribrostatin 6. J Med Microbiol. 2004;53:61-65. https://doi.org/10.1099/jmm.0.05250-0
  140. Pimentel SM, Bojo ZP, Roberto AV, Lazaro JE, Mangalindan GC, Florentino LM, Lim-Navarro P, Tasdemir D, Ireland CM, Concepcion GP. Platelet aggregation inhibitors from Philippine marine invertebrate samples screened in a new microplate assay. Mar Biotechnol. 2003;5:395-400. https://doi.org/10.1007/s10126-002-0080-3
  141. Portela C, Afonso CMM, Madalena MM, Pinto MMM, Ramos MJ. Definition of an electronic profile of compounds with inhibitory activity against hematin aggregation in malaria parasite. Bioorg & Med Chem. 2004;12:3313-3321. https://doi.org/10.1016/j.bmc.2004.03.060
  142. Posadas I, De Rosa S, Terencio MC, Paya M, Alcaraz MJ. Cacospongionolide B suppresses the expression of inflammatory enzymes and tumour necrosis factor-alpha by inhibiting nuclear factor-kappa B activation. Br J Pharmacol. 2003a;138:1571-1579. https://doi.org/10.1038/sj.bjp.0705189
  143. Posadas I, Terencio MC, Randazzo A, Gomez-Paloma L, Paya M, Alcaraz MJ. Inhibition of the NF-kappaB signaling pathway mediates the anti-inflammatory effects of petrosaspongiolide M. Biochem Pharmacol. 2003b;65:887-895. https://doi.org/10.1016/S0006-2952(02)01659-3
  144. Potterat O, Hamburger M. Natural Products in Drug Discovery - Concepts and Approaches for Tracking Bioactivity. Curr Org Chem. 2006;10:899-920. https://doi.org/10.2174/138527206776894401
  145. Proksch P, Ebel R, Edrada RA, Schupp P, Lin HW, Sudarsono,Wray V, Steube K. Detection of pharmacologically active natural products using ecology : selected examples from indopacific marine invertebrates and sponge-derived fungi. Pure Appl Chem. 2003b;75:343-352. https://doi.org/10.1351/pac200375020343
  146. Proksch P, Ebel R, Edrada RA, Wray V, Steube K. Bioactive natural products from marine invertebrates and associated fungi. In Sponges (Porifera). Muller WEG ed. (Berlin, Germany: Springer-Verlag), pp. 117-142, 2003.
  147. Qi J, Ojika M, Sakagami Y. Linckosides C-E, three new neuritogenic steroid glycosides from the Okinawan starfish Linckia laevigata. Bioorg Med Chem. 2004;12:4259-4265. https://doi.org/10.1016/j.bmc.2004.04.049
  148. Radhika P, Cabeza M, Bratoeff E, Garcia G. 5Alpha-reductase inhibition activity of steroids isolated from marine soft corals. Steroids. 2004;69:439-444. https://doi.org/10.1016/j.steroids.2004.04.001
  149. Rao KV, Santarsiero BD, Mesecar AD, Schinazi RF, Tekwani BL, Hamann MT. New manzamine alkaloids with activity against infectious and tropical parasitic diseases from an Indonesian sponge. J Nat Prod. 2003;66:823-828. https://doi.org/10.1021/np020592u
  150. Rath G, Potterat O, Mavi S, Hostettmann K. Xanthones from Hypericum roeperanum. Phytochem. 1996;43:513-520. https://doi.org/10.1016/0031-9422(96)00284-1
  151. Rezwan M, Laneelle M-A, Sander P, Daffe M. Breaking down the wall: fractionation of mycobacteria. J Microbiol Methods. 2007;68:32-39. https://doi.org/10.1016/j.mimet.2006.05.016
  152. Rifai S, Fassouane A, Kijjoa A, Van Soest R. Antimicrobial Activity of Untenospongin B, a Metabolite from the Marine Sponge Hippospongia communis collected from the Atlantic Coast of Morocco. Mar Drugs. 2004;2:147-153. https://doi.org/10.3390/md203147
  153. Rijal S, Yardley V, Chappuis F, Decuypere S, Khanal B, Singh R, Boelaert M, De Doncker S, Croft S, Dujardin J-C. Antimonial treatment of visceral leishmaniasis: are current in vitro susceptibility assays adequate for prognosis of in vivo therapy outcome?. Microbes Infect. 2007;9:529-535. https://doi.org/10.1016/j.micinf.2007.01.009
  154. Roch P, Beschin A, Bernard E. Antiprotozoan and Antiviral Activities of Non-cytotoxic Truncated and Variant Analogues of Mussel Defensin. Evid Based Complement Alternat Med. 2004;1;167-174. https://doi.org/10.1093/ecam/neh033
  155. Rodriguez II, Rodriguez AD. Homopseudopteroxazole, a new antimycobacterial diterpene alkaloid from Pseudopterogorgia elisabethae. J Nat Prod. 2003;66:855-857. https://doi.org/10.1021/np030052c
  156. Rodriguez II, Shi YP, García OJ, Rodriguez AD, Mayer AM, Sanchez JA, Ortega Barria E, Gonzalez J. New pseudopterosin and seco-pseudopterosin diterpene glycosides from two Colombian isolates of Pseudopterogorgia elisabethae and their diverse biological activities. J Nat Prod. 2004;67:1672-1680. https://doi.org/10.1021/np049802o
  157. Sakai R, Matsubara H, Shimamoto K, Jimbo M, Kamiya H, Namikoshi M. Isolations of N-methyl-D-aspartic acid-type glutamate receptor ligands from Micronesian sponges. J Nat Prod. 2003;66:784-787. https://doi.org/10.1021/np020590+
  158. Sakai R, Suzuki K, Shimamoto K, Kamiya H. Novel betaines from a micronesian sponge Dysidea herbacea. J Org Chem. 2004;69:1180-1185. https://doi.org/10.1021/jo0355045
  159. Salem MM, Werbovetz KA. Natural products from plants as drug candidates and lead compounds against leishmaniasis and trypanosomiasis. Curr Med Chem. 2006;13:2571-2598. https://doi.org/10.2174/092986706778201611
  160. Sandsdalen E, Haug T, Stensvag K, Styrvold OB. The antibacterial effect of a polyhydroxylated fucophlorethol from the marine brown alga, Fucus vesiculosus. World J Microbiol Biotechnol. 2003;19:777-782. https://doi.org/10.1023/A:1026052715260
  161. Satitpatipan V, Suwanborirux K. New nitrogenous Germacranes from a Thai marine sponge, Axinyssa n. sp. J Nat Prod. 2004;67:503-505. https://doi.org/10.1021/np030349a
  162. Savoia D, Avanzini C, Allice T, Callone E, Guella G, Dini F. Antimicrob. Antimicrobial activity of euplotin C, the sesquiterpene taxonomic marker from the marine ciliate Euplotes crassus. Antimicrob Agents Chemother. 2004;48:3828-3833. https://doi.org/10.1128/AAC.48.10.3828-3833.2004
  163. Schluger NW. The pathogenesis of tuberculosis: the first one hundred (and twenty-three) years. Am J Respir Cell Mol Biol. 2005;32:251-256. https://doi.org/10.1165/rcmb.F293
  164. Schmitz FJ, Bowden BF, Toth SI. Antitumor and Cytotoxic Compounds from Marine Organisms. In Marine Biotechnology, Pharmaceutical and Bioactive Natural Products, vol 1. Attaway DH, Zaborsky OR eds. (New York, USA: Plenum Press), pp. 197-308, 1993.
  165. Schupp P, Poehner T, Edrada R, Ebel R, Berg A, Wray V, Proksch P. Eudistomins W and X, two new beta-carbolines from the micronesian tunicate Eudistoma sp. J Nat Prod. 2003;66:272-275. https://doi.org/10.1021/np020315n
  166. Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. J Biol Chem. 2003;278:40317-40323. https://doi.org/10.1074/jbc.M213030200
  167. Smith I. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev. 2003;16:463-496. https://doi.org/10.1128/CMR.16.3.463-496.2003
  168. Somoskovi A, Dormandy J, Parsons LM, Kaswa M, Goh KS, Rastogi N, Salfinger M. Sequencing of the pncA gene in members of the Mycobacterium tuberculosis complex has important diagnostic applications: Identification of a species-specific pncA mutation in "Mycobacterium canettii" and the reliable and rapid predictor of pyrazinamide resistance. J Clin Microbiol. 2007;45:595-599. https://doi.org/10.1128/JCM.01454-06
  169. Soto J, Berman J. Treatment of New World cutaneous leishmaniasis with miltefosine. Trans R Soc Trop Med Hyg. 2006;100suppl1:S34-S40. https://doi.org/10.1016/j.trstmh.2006.02.022
  170. Staats PS, Yearwood T, Charapata SG, Presley RW, Wallace MS, Byas-Smith M, Fisher R, Bryce DA, Mangieri EA, Luther RR, Mayo M, McGuire D, Ellis D. Intrathecal ziconotide in the treatment of refractory pain in patients with cancer or AIDS: a randomized controlled trial. JAMA. 2004;291:63-70. https://doi.org/10.1001/jama.291.1.63
  171. Sudarslal S, Majumdar S, Ramasamy P, Dhawan R, Pal PP, Ramaswami M, Lala AK, Sikdar SK, Sarma SP, Krishnan KS, Balaram P. Sodium channel modulating activity in a delta-conotoxin from an Indian marine snail. FEBS Lett. 2003;553:209-212. https://doi.org/10.1016/S0014-5793(03)01016-0
  172. Sultanbawa MUS. Xanthonoids of tropical plants. Tetrahedron. 1980;36:1465-1506. https://doi.org/10.1016/S0040-4020(01)83114-8
  173. Takada K, Uehara T, Nakao Y, Matsunaga S, van Soest RW, Fusetani N. Schulzeines A-C, new alpha-glucosidase inhibitors from the marine sponge Penares schulzei. J Am Chem Soc. 2004;126:187-193. https://doi.org/10.1021/ja037368r
  174. Takamatsu S, Hodges TW, Rajbhandari I, Gerwick WH, Hamann MT, Nagle DG. Marine natural products as novel antioxidant prototypes. J Nat Prod. 2003;66:605-608. https://doi.org/10.1021/np0204038
  175. Theerachayanan T, Sirithunyalug B, Piyamongkol S. Antimalarial and antimycobacterial activities of dimeric naphthoquinones from Diospyros glandulosa and Diospyros rhodocalyx. CMU J Nat Sci. 2007;6:253-259.
  176. Tierney D, Nardell EA. Tuberculosis (TB). Available at: http://www.merckmanuals.com/home/infections/tuberculosis-and-leprosy/tuberculosis-tb (accessed on 09th November 2016).
  177. Tincu JA, Menzel LP, Azimov RS. Hong T, Waring AJ, Taylor SW, Lehrer RI. Plicatamide, an antimicrobial octapeptide from Styela plicata hemocytes. J Biol Chem. 2003;278:13546-13553. https://doi.org/10.1074/jbc.M211332200
  178. Tincu JA, Taylor SW. Antimicrobial peptides from marine invertebrates. Antimicrob. Agents Chemother. 2004;48:3645-3654. https://doi.org/10.1128/AAC.48.10.3645-3654.2004
  179. Tiruviluamala P, Reichman LB. Tuberculosis. Annu Rev Public Health. 2002;23:403-426. https://doi.org/10.1146/annurev.publhealth.23.100901.140519
  180. Tosuji H, Fusetani N, Seki Y. Calyculin A causes the activation of histone H1 kinase and condensation of chromosomes in unfertilized sea urchin eggs independently of the maturation-promoting factor. Comp Biochem Physiol Part C Pharmacol. 2003;135:415-424.
  181. Trager W, Jensen JB. Human malaria parasites in continuous culture. Science. 1976;193:673-677. https://doi.org/10.1126/science.781840
  182. Tran QL, Tezuka Y, Ueda J-Y, Nguyen NT, Maruyama Y, Begum K, Kim HS, Wataya Y, Tran QK, Kadota S. In vitro antiplasmodial activity of antimalarial medicinal plants used in Vietnamese traditional medicine. J Ethnopharmacol. 2003;86:249-252. https://doi.org/10.1016/S0378-8741(03)00045-X
  183. Trevisi L, Cargnelli G, Ceolotto G, Papparella I, Semplicini A, Zampella A, D'Auria MV, Luciani S. Callipeltin A: sodium ionophore effect and tension development in vascular smooth muscle. Biochem Pharmacol. 2004;68:1331-1338. https://doi.org/10.1016/j.bcp.2004.04.032
  184. Tsai MC, Chakravarty S, Zhu G, Xu J, Tanaka K, Koch C, Tufariello J, Flynn J, Chan J. Characterization of the tuberculous granuloma in murine and human lungs: cellular composition and relative tissue oxygen tension. Cell Microbiol. 2006;8:218-232. https://doi.org/10.1111/j.1462-5822.2005.00612.x
  185. Tsang CK, Kamei Y. Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent manner. Eur J Pharmacol. 2004 488:11-18. https://doi.org/10.1016/j.ejphar.2004.01.033
  186. Tsukamoto S, Miura S, Yamashita Y, Ohta T. Aspermytin A: a new neurotrophic polyketide isolated from a marine-derived fungus of the genus Aspergillus. Bioorg Med Chem Lett. 2004a;14:417-420. https://doi.org/10.1016/j.bmcl.2003.10.053
  187. Tsukamoto S, Tatsuno M, van Soest RW, Yokosawa H, Ohta T. New polyhydroxy sterols: proteasome inhibitors from a marine sponge Acanthodendrilla sp. J Nat Prod. 2003;66:1181-1185. https://doi.org/10.1021/np030120v
  188. Tsukamoto S, Yamashita Y, Yoshida T, Ohta T. Parguerol and isoparguerol isolated from the Sea Hare, Aplysia kurodai, induce neurite outgrowth in PC-12 cells. Mar Drugs. 2004b 2:170-175. https://doi.org/10.3390/md204170
  189. Tucker SJ, McClelland D, Jaspars M, Sepcic K, MacEwan DJ, Scott RH. The influence of alkyl pyridinium sponge toxins on membrane properties, cytotoxicity, transfection and protein expression in mammalian cells. Biochim Biophys Acta. 2004;1614:171-181.
  190. Tziveleka LA, Vagias C, Roussis V. Natural products with anti-HIV activity from marine organisms. Curr Top Med Chem. 2003;3;1512-1535. https://doi.org/10.2174/1568026033451790
  191. Uchida T, Yamasaki T, Eto S, Sugawara H, Kurisu G, Nakagawa A, Kusunoki M, Hatakeyama T. Crystal structure of the hemolytic lectin CEL-III isolated from the marine invertebrate Cucumaria echinata: implications of domain structure for its membrane pore-formation mechanism. J Biol Chem. 2004;279:37133-37141. https://doi.org/10.1074/jbc.M404065200
  192. Verbitski SM, Mullally JE, Fitzpatrick FA, Ireland CM. Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity. J Med Chem. 2004;47:2062-2070. https://doi.org/10.1021/jm030448l
  193. Vetvicka V, Yvin JC. Effects of marine beta-1,3 glucan on immune reactions. Int Immunopharmacol. 2004;4:721-730. https://doi.org/10.1016/j.intimp.2004.02.007
  194. Villar RM, Gil-Longo J, Daranas AH, Souto ML, Fernandez JJ, Peixinho S, Barral MA, Santafe G, Rodriguez J, Jimenez C. Evaluation of the effects of several zoanthamine-type alkaloids on the aggregation of human platelets. Bioorg Med Chem. 2003;11:2301-2306. https://doi.org/10.1016/S0968-0896(03)00107-X
  195. Wang CY, Wang BG, Wiryowidagdo S, Wray V, Van Soest R, Steube KG, Guan HS, Proksch P, Ebel R. Melophlins C-O, thirteen novel tetramic acids from the marine sponge Melophlus sarassinorum. J Nat Prod. 2003a;66:51-56. https://doi.org/10.1021/np0202778
  196. Wei X, Rodríguez AD, Baran P, Raptis RG, Sanchez JA, Ortega-Barria E, Gonzalez J. Antiplasmodial cembradiene diterpenoids from a Southwestern Caribbean gorgonian octocoral of the genus Eunicea. Tetrahedron. 2004;60:11813-11819. https://doi.org/10.1016/j.tet.2004.09.108
  197. WHO. Malaria. Available at: http://www.who.int/mediacentre/factsheets/fs094/en/index.html (accessed on 22nd June 2007).
  198. Willert EK, Fitzpatrick R, Phillips MA. Allosteric regulation of an essential trypanosome polyamine biosynthetic enzyme by a catalytically dead homolog. Proc Natl Acad Sci USA. 2007;104:8275-8280. https://doi.org/10.1073/pnas.0701111104
  199. Williams DE, Lapawa M, Feng X, Tarling T, Roberge M, Andersen RJ. Spirastrellolide A: revised structure, progress toward the relative configuration, and inhibition of protein phosphatase 2A.Org Lett. 2004a;6;2607-2610. https://doi.org/10.1021/ol0490983
  200. Williams DE, Telliez JB, Liu J, Tahir A, Van Soest R, Andersen RJ. Meroterpenoid MAPKAP (MK2) inhibitors isolated from the indonesian marine sponge Acanthodendrilla sp. J Nat Prod. 2004b;67;2127-2129. https://doi.org/10.1021/np049808d
  201. Wonganuchitmeta SN, Yuenyongsawad S, Keawpradub N, Plubrukarn A. Antitubercular sesterterpenes from the Thai sponge Brachiaster sp. J Nat Prod. 2004;67;1767-1770. https://doi.org/10.1021/np0498354
  202. World Health Organization. New Plan to Contain Drug-Resistant TB. WHO. 2007. Available at: http://www.who.int/mediacentre/news/releases/2007/pr32/en/index.html (accessed on 24th June 2007).
  203. World Health Organization. Report of the Scientific Working Group on Chagas Disease Buenos Aires, Argentina 17-20 April 2005. (Geneva, Switzerland: WHO), 2005.
  204. World Health Organization. Report of the WHO Informal Consultation on the Evaluation and Testing of Insecticides. CTD/WHOPES/IC. Control of Tropical Diseases Division. (Geneva, Switzerland: World Health Organization), p. 69, 1996.
  205. World Health Organization. The Promotion and development of traditional medicine. (Geneva, Switzerland: World Health Organization), 1978.
  206. World Health Organization. The world health report 1998-Life in the 21st century: a vision for all. (Geneva, Switzerland: World Health Organization), p. 98, 1998.
  207. World Health Organization. What Is Malaria? (Geneva, Switzerland: World Health Organization), 2001.
  208. Xu N, Fan X, Yan X, Li X, Niu R, Tseng CK. Antibacterial bromophenols from the marine red alga Rhodomela confervoides. Phytochemistry. 2003;62;1221-1224. https://doi.org/10.1016/S0031-9422(03)00004-9
  209. Yamada T, Iritani M, Minoura K, Kawai K, Numata A. Peribysins A-D, potent cell-adhesion inhibitors from a sea hare-derived culture of Periconia species. Org Biomol Chem. 2004;2:2131-2135. https://doi.org/10.1039/B404459B
  210. Yang SW, Buivich A, Chan TM, Smith M, Lachowicz J, Pomponi SA, Wright AE, Mierzwa R, Patel M, Gullo V, Chu M. A new sterol sulfate, Sch 572423, from a marine sponge, Topsentia sp. Bioorg Med Chem Lett. 2003a;13:1791-1794. https://doi.org/10.1016/S0960-894X(03)00260-9
  211. Yang SW, Chan TM, Pomponi SA, Chen G, Loebenberg D, Wright A, Patel M, Gullo V, Pramanik B, Chu M. Structure elucidation of a new antifungal sterol sulfate, Sch 575867, from a deep-water marine sponge (Family: Astroscleridae). J Antibiot (Tokyo). 2003b;56:186-189. https://doi.org/10.7164/antibiotics.56.186
  212. Yang SW, Chan TM, Pomponi SA, Chen G, Wright AE, Patel M, Gullo V, Pramanik B, Chu M. A new bicyclic guanidine alkaloid, Sch 575948, from a marine sponge, Ptilocaulis spiculifer. J Antibiot (Tokyo). 2003c;56,970-972. https://doi.org/10.7164/antibiotics.56.970
  213. Yang SW, Chan TM, Pomponi SA, Gonsiorek W, Chen G, Wright AE, HipkinW, Patel M, GulloV, Pramanik B, Zavodny P, Chu M. A new sesterterpene, Sch 599473, from a marine sponge, Ircinia sp. J Antibiot (Tokyo). 2003d;56;783-786. https://doi.org/10.7164/antibiotics.56.783
  214. Yang XD, Xu LZ, Yang SL. Xanthones from the stems of Securidaca inappendiculata. Phytochemistry. 2001;58:1245-1249. https://doi.org/10.1016/S0031-9422(01)00356-9
  215. Yim JH, Kim SJ, Ahn SH, Lee CK, Rhie KT, Lee HK. Antiviral effects of sulfated exopolysaccharide from the marine microalga Gyrodinium impudicum strain KG03. Mar Biotechnol (NY). 2004;6:17-25. https://doi.org/10.1007/s10126-003-0002-z
  216. Yoo HD, Sanghara J, Daley D, Van Soest R, Andersen RJ. Isoarenarol, a new protein kinase inhibitor from the marine sponge Dysidea arenaria. Pharm Biol. 2003;41:223-225. https://doi.org/10.1076/phbi.41.4.223.15679
  217. Zancan P, Mourao PA. Venous and arterial thrombosis in rat models: dissociation of the antithrombotic effects of glycosaminoglycans. Blood Coagul Fibrinolysis. 2004;15:45-54. https://doi.org/10.1097/00001721-200401000-00008
  218. Zhang W, Xue S, Zhao Q, Zhang X, Li J, Jin M, Yu X, Yuan Q. Biopotentials of marine sponges from China oceans: past and future. Biomol Eng. 2003;20;413-419. https://doi.org/10.1016/S1389-0344(03)00066-2
  219. ZhuW, Chiu LC, Ooi VE, Chan PK, Ang Jr PO. Antiviral property and mode of action of a sulphated polysaccharide from Sargassum patens against herpes simplex virus type 2. Int J Antimicrob Agents. 2004;24:279-283. https://doi.org/10.1016/j.ijantimicag.2004.02.022