Effects of Fermented Goat Milk on Immunomodulatory Activity and Physical Strength in Mice

산양유 발효유의 면역 활성 및 체력증진 효과

  • Oh, Kwang-Hoon (Department of Physical Education, College of Education, Kongju National University) ;
  • Kim, A Rong (Department of Microbiology, College of Medicine, Konyang University) ;
  • Bae, Jong-Hwan (Research Institute, Bioprogen Co., Ltd.) ;
  • Lee, Kyung Bok (Department of Biochemistry, College of Medicine, Konyang University) ;
  • Yoo, Yung Choon (Department of Microbiology, College of Medicine, Konyang University)
  • 오광훈 (공주대학교 사범대학 체육교육과) ;
  • 김아롱 (건양대학교 의과대학 미생물학교실) ;
  • 배종환 ((주)바이오프로젠) ;
  • 이경복 (건양대학교 의과대학 생화학교실) ;
  • 유영춘 (건양대학교 의과대학 미생물학교실)
  • Received : 2015.10.20
  • Accepted : 2015.12.09
  • Published : 2016.02.29


In this study, the effects of fermented goat milk (F-GM) on immunological activity and physical strength were examined. Splenocytes obtained from mice administered with F-GM showed increased responsinveness to mitogens, concanavalin-A (ConA), and lipopolysaccharide (LPS). Treatment with F-GM also significantly augmented production of interleukin (IL)-2 and interferon (IFN)-${\gamma}$, but not IL-4 or IL-10 from ConA-stimulated splenocytes. The activity of F-GM administration to enhance production of IL-2 and IFN-${\gamma}$ was confirmed based on mRNA expression of these cytokines by reverse transcription polymerase chain reaction. After immunization with keyhole limpet hemocyanin (KLH, 20 mg/mouse), mice administered F-GM showed significantly higher antibody titers against KLH than those of phosphate-buffered saline-treated mice, and showed the highest titer 5 weeks after KLH immunization. Analysis for determining isotypes of antibodies revealed that administration of F-GM elicited KLH-specific antibody titers of IgG1, IgG2a, and IgM. In a delayed type hypersensitivity (DTH) test carried out 7 weeks after the primary immunization, F-GM-treated mice showed a higher DTH reaction than the control mice. Furthermore, the swimming test found that administration of F-GM significantly increased swimming time. These results suggest that administration of F-GM enhances not only immune responses against antigens but also physical strength.


Supported by : 농림축산식품부, 한국연구재단


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