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The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Skin Volume Augmentation and Anti-wrinkle Effects of Tribulus terrestris Fruit Extract

질려자 추출물의 피부 볼륨 증진 및 주름개선 효과

  • Kim, Mi Jin (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.) ;
  • Jung, Taek Kyu (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.) ;
  • Park, Hyun-Chul (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.) ;
  • Yoon, Kyung-Sup (Skin Science R&D Center, Saimdang Cosmetics Co., Ltd.)
  • 김미진 ((주)사임당화장품 피부과학연구소) ;
  • 정택규 ((주)사임당화장품 피부과학연구소) ;
  • 박현철 ((주)사임당화장품 피부과학연구소) ;
  • 윤경섭 ((주)사임당화장품 피부과학연구소)
  • Received : 2016.06.27
  • Accepted : 2016.09.23
  • Published : 2016.09.30
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Abstract

Aging of the face is mainly related to the features that are sagging or loss of elasticity of the skin by reducing the volume around the eyes or cheek. Intrinsic aging can be seen to cause thinner dermis, reduction of extracellular matrix and subcutaneous fat. This study was carried out to investigate the skin volume augmentation and anti-wrinkle effects of Tribulus terrestris fruit extract. Skin anti-aging effect of Tribulus terrestris fruit extract was evaluated by using lipid accumulation, expressin of type I procollagen and elastin in preadipocytes and human dermal fibroblasts. Tribulus terrestris fruit extract augmented preadipocytes differentiation about 56% at 100 µg/mL. The type I procollagen and elastin were increased about 35% and 25% by treatment 20% Tribulus terrestris fruit extract, respectively. The clinical study also showed that skin sagging, skin elasticity, and dermal density improved without adverse effect following 4 week application of cream containing 2% Tribulus terrestris fruit extract. We suggest that Tribulus terrestris fruit extract can have the good possibility as skin volume augmenting, skin elasticity and wrinkle improving agent.

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References

  1. Friedman, O. (2005) Changes associated with the aging face. Facial Plast. Surg. Clin. North. Am. 13: 371-380. https://doi.org/10.1016/j.fsc.2005.04.004
  2. Lapiere, C. M. (1990) The ageing dermis: the main cause for the appearance of 'old' skin. Br. J. Dermatol. 35: 5-11.
  3. Gilchrest, B. A. (1989) Skin aging and photoaging: an overview. J. Am. Acad. Dermatol. 21: 610-613. https://doi.org/10.1016/S0190-9622(89)70227-9
  4. Zoumalan, R. A. and W. F. Jr. Larrabee (2011) Anatomic considerations in the aging face. Facial Plast. Surg. 27: 16-22. https://doi.org/10.1055/s-0030-1270420
  5. DeFatta, R. J. and E. F. 3rd Williams (2011) Midface lifting: current standards. Facial Plast Surg. 27: 77-85. https://doi.org/10.1055/s-0030-1270417
  6. Angelos, P. C., C. L. Stallworth, and T. D. Wang (2011) Forehead lifting: state of the art. Facial Plast. Surg. 27: 50-57. https://doi.org/10.1055/s-0030-1270419
  7. Park, J. Y.,and J. H. Bae (2012) Understanding of the aging face. J. Rhinol. 19: 87-90.
  8. Ohshima, H., S. Kinoshita, M. Oyobikawa, M. Futaqawa, H. Takiwaki, A. Ishiko, and H. Kanto (2013) Use of cutometer area parameters in evaluating age-related changes in the skin elasticity of the cheek. Skin Res. Technol. 19: e238-242. https://doi.org/10.1111/j.1600-0846.2012.00634.x
  9. Escoffier, C., J. de Rigal, A. Rochefort, R. Vasselet, J. L. Leveque, and P. G. Aqache (1989). Age-related mechanical properties of human skin: an in vivo study. J. Invest. Dermatol. 93: 353-357. https://doi.org/10.1016/0022-202X(89)90058-4
  10. Mentz, H. A., A. Ruiz-Razura, C. K. Patronella, and G. Newall (2005) Facelift: measurement of superficial muscular aponeurotic system advancement with and without zygomaticus major muscle release. Aesthetic Plast. Surg. 29: 353-362. https://doi.org/10.1007/s00266-005-0005-4
  11. You, Y. J. and H. S. Lee (1999) Effects of fructus Tribuli on the blood pressure in spontaneously hypertensive rats. The Journal of Traditional Korean Medicine 9: 192-199.
  12. Kang, S. Y., J. H. Han, and K. Y. Kim (1998) Effect of fructus Tribuli extract on regional cerebral blood flow and pil arterial diameter. J. Herbol. 13: 187-200.
  13. Lee, D. H., H. H. Yu, S. Y. Jung, H. D. Moon, S. M. Kim, B. H. Jeon, and Y. O. You (2007) Anticariogenic properties of the ethanol extract of Tribuli fructus against Streptococcus mutans. Korean J. Oriental Physiol. Pathol. 21: 1148-1153.
  14. Zhang, J. D, Y. B. Cao, Z. Xu, H. H. Sun, M. M. An, L. Yan, H. S. Chen, P. H. Gao, Y. Wang, X. M. Jia, and Y. Y. Jiang (2005) In vitro and in vivo antifungal activities of the eight steroid saponins from Tribulus terrestris L. with potent activity against Fluconazole- resistant fungal. Biol. Pharm. Bull. 28: 2211-2215. https://doi.org/10.1248/bpb.28.2211
  15. Fang, S., C. Hao, Z. Liu, F. Song, and S. Liu (1999) Application of electrospray ionization mass spectrometry combined with sequential tandem mass spectrometry techniques for the steroidal saponin mixture extracted from Tribulus terrestris. Planta Med. 65: 68-73. https://doi.org/10.1055/s-1999-13966
  16. Kostova, I., D. Dinchev, G. H. Rentsch, V. Dimitrov, and A. Ivanova (2002) Two new sulfated furostanol saponins from Tribulus terrestris. Z. Naturforsch 57: 33-38.
  17. Li, J. X., Q. Shi, Q. B. Xiong, J. K. Prasain, Y. Tezuka, T. Hareyama, Z. T. Wang, K. Tanaka, T. Namba, and S. Kadota (1998) Tribulusamide A and B, new hepatoprotective lignanamides from the fruits of Tribulus terrestirs, Indications of cytoprotective activity in murine hepatocyte culture. Planta Med. 64: 628-631. https://doi.org/10.1055/s-2006-957535
  18. Wu, T. S., L. S. Shi, and S. C. Kuo (1999) Alkaloids and other constituents from Tribulus terrestris. Phytochemistry 50: 1411-1415. https://doi.org/10.1016/S0031-9422(97)01086-8
  19. Hong, S. S, W. S. Jeong, J. G. Kwon, Y. H. Choi, E. K. Ahn, H. J. Ko, D. W. Seo, and J. S. Oh (2013) Phenolic amides from the fruits of Tribulus terrestris and their inhibitory effects on production of nitric oxide. Bull. Korean Chem. Soc. 34: 3105-3108. https://doi.org/10.5012/bkcs.2013.34.10.3105
  20. Sedama. (2007) Cosmetic composition containing sarsasapogenin. JP 21545582.
  21. Green, L. M., J. L. Reade, and C. F. Ware (1984) Rapid colorimetric assay for cell viability: application to the quantitation of cytotoxic and growth inhibitory lymphokines. J. Immunol. Methods 70: 257-268. https://doi.org/10.1016/0022-1759(84)90190-X
  22. Huang, K. C. (1999) The pharmacology of chinese herbs. 2nd ed., pp. 165. CRC Press LLC, USA.
  23. Wu, Y., Z. R. Wu, P. Chen, L. Yang, W. R. Deng, Y. Q. Wang, and H. Y. Li (2015) Effect of the tyrosinase inhibitor (S)-N-trans-feruloyloctopamine from garlic skin on tyrosinase gene expression and melanine accumulation in melanoma cells. Bioorg. Med. Chem. Lett. 25: 1476-1478. https://doi.org/10.1016/j.bmcl.2015.02.028
  24. Lee, D. G., Y. K. Park, M. R. Kim, H. J. Jung, Y. B. Seu, K. S. Hahm, and E. R. Woo (2004) Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense. Biotechnol. Lett. 26: 1125-1130. https://doi.org/10.1023/B:BILE.0000035483.85790.f7
  25. Li, W. J., X. L. Cheng, J. Liu, R. C. Lin, G. L. Wang, S. S. Du, and Z. L. Liu (2012) Phenolic compounds and antioxidant activities of Liriope muscari. Molecules 17: 1797-1808. https://doi.org/10.3390/molecules17021797
  26. Song, Y. H., D. W. Kim, M. J. Curtis-Long, C. Park, M. Son, J. Y. Kim, H. J. Yuk, K. W. Lee, and K. H. Park (2016) Cinnamic acid amides from Tribulus terrestris displaying uncompetitive ${\alpha}$-glucosidase inhibition. Eur. J. Med. Chem. 114: 201-208. https://doi.org/10.1016/j.ejmech.2016.02.044