Toxicological Research

  • 제32권2호
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  • Pages.109-114
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  • 2016
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis

  • Han, Sang-Chul (Department of Medicine, School of Medicine, Jeju National University) ;
  • Kang, Na-Jin (Department of Medicine, School of Medicine, Jeju National University) ;
  • Yoon, Weon-Jong (Jeju Biodiversity Research Institute (JBRI)) ;
  • Kim, Sejin (Department of Medicine, School of Medicine, Jeju National University) ;
  • Na, Min-Chull (Department of Medicine, School of Medicine, Jeju National University) ;
  • Koh, Young-Sang (Department of Medicine, School of Medicine, Jeju National University) ;
  • Hyun, Jin-Won (Department of Medicine, School of Medicine, Jeju National University) ;
  • Lee, Nam-Ho (Department of Chemistry, College of Natural Science, Jeju National University) ;
  • Ko, Mi-Hee (Jeju Biodiversity Research Institute (JBRI)) ;
  • Kang, Hee-Kyoung (Department of Medicine, School of Medicine, Jeju National University) ;
  • Yoo, Eun-Sook (Department of Medicine, School of Medicine, Jeju National University)
  • 투고 : 2015.10.20
  • 심사 : 2016.01.27
  • 발행 : 2016.04.15
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초록

Allergic skin inflammation such as atopic dermatitis is characterized by skin barrier dysfunction, edema, and infiltration with various inflammatory cells. The anti-inflammatory effects of Apo-9'-fucoxanthinone, isolated from Sargassum muticum, have been described in many diseases, but the mechanism by which it modulates the immune system is poorly understood. In this study, the ability of Apo-9'-fucoxanthinone to suppress allergic reactions was investigated using a mouse model of atopic dermatitis. The Apo-9'-fucoxanthinone-treated group showed significantly decreased immunoglobulin E in serum. Also, Apo-9'-fucoxanthinone treatment resulted in a smaller lymph node size with reduced the thickness and length compared to the induction group. In addition, Apo-9'-fucoxanthinone inhibited the expression of interleukin-4, interferon-gamma and tumor necrosis factor-alpha by phorbol 12-myristate 13-acetate and ionomycin-stimulated lymphocytes. These results suggest that Apo-9'-fucoxanthinone may be a useful therapeutic strategy for treating chronic inflammatory diseases.

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참고문헌

  1. Leung, D.Y., Boguniewicz, M., Howell, M.D., Nomura, I. and Hamid, Q.A. (2004) New insights into atopic dermatitis. J. Clin. Invest., 113, 651-657. https://doi.org/10.1172/JCI21060
  2. Li, C., Lasse, S., Lee, P., Nakasaki, M., Chen, S.W., Yamasaki, K., Gallo, R.L. and Jamora, C. (2010) Development of atopic dermatitis-like skin disease from the chronic loss of epidermal caspase-8. Proc. Natl. Acad. Sci. U.S.A., 107, 22249-22254. https://doi.org/10.1073/pnas.1009751108
  3. Nystad, W., Roysamb, E., Magnus, P., Tambs, K. and Harris, J.R. (2005) A comparison of genetic and environmental variance structures for asthma, hay fever and eczema with symptoms of the same diseases: a study of Norwegian twins. Int. J. Epidemiol., 34, 1302-1309. https://doi.org/10.1093/ije/dyi061
  4. Wahlgren, C.F. (1999) Itch and atopic dermatitis: an overview. J. Dermatol., 26, 770-779. https://doi.org/10.1111/j.1346-8138.1999.tb02090.x
  5. Kawakami, T., Ando, T., Kimura, M., Wilson, B.S. and Kawakami, Y. (2009) Mast cells in atopic dermatitis. Curr. Opin. Immunol., 21, 666-678. https://doi.org/10.1016/j.coi.2009.09.006
  6. Kitamura, Y. and Ito, A. (2005) Mast cell-committed progenitors. Proc. Natl. Acad. Sci. U.S.A., 102, 11129-11130. https://doi.org/10.1073/pnas.0505073102
  7. Leitges, M., Gimborn, K., Elis, W., Kalesnikoff, J., Hughes, M.R., Krystal, G. and Huber, M. (2002) Protein kinase C-${\delta}$ is a negative regulator of antigen-induced mast cell degranulation. Mol. Cell. Biol., 22, 3970-3980. https://doi.org/10.1128/MCB.22.12.3970-3980.2002
  8. Glimcher, L.H. and Murphy, K.M. (2000) Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev., 14, 1693-1711.
  9. Ouyang, W., Ranganath, S.H., Weindel, K., Bhattacharya, D., Murphy, T.L., Sha, W.C. and Murphy, K.M. (1998) Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity, 9, 745-755. https://doi.org/10.1016/S1074-7613(00)80671-8
  10. Romagnani, S. (2000) The role of lymphocytes in allergic disease. J. Allergy Clin. Immunol., 105, 399-408. https://doi.org/10.1067/mai.2000.104575
  11. Elson, C.O., Cong, Y., Brandwein, S., Weaver, C.T., McCabe, R.P., Mahler, M., Sundberg, J.P. and Leiter, E.H. (1998) Experimental models to study molecular mechanisms underlying intestinal inflammation. Ann. N. Y. Acad. Sci., 859, 85-95. https://doi.org/10.1111/j.1749-6632.1998.tb11113.x
  12. Chae, D., Manzoor, Z., Kim, S.C., Kim, S., Oh, T.H., Yoo, E.S., Kang, H.K., Hyun, J.W., Lee, N.H., Ko, M.H. and Koh, Y.S. (2013) Apo-9'-fucoxanthinone, isolated from Sargassum muticum, inhibits CpG-induced inflammatory response by attenuating the mitogen-activated protein kinase pathway. Mar. Drugs, 11, 3272-3287. https://doi.org/10.3390/md11093272
  13. Han, S.C., Kang, G.J., Ko, Y.J., Kang, H.K., Moon, S.W., Ann, Y.S. and Yoo, E.S. (2012) External application of fermented olive flounder (paralichthys olivaceus) oil alleviates inflammatory responses in 2,4-dinitrochlorobenzene-induced atopic dermatitis mouse model. Toxicol. Res., 28, 159-164. https://doi.org/10.5487/TR.2012.28.3.159
  14. Jo, W.S., Choi, Y.J., Kim, H.J., Nam, B.H., Lee, G.A., Seo, S.Y., Lee, S.W. and Jeong, M.H. (2010) Methanolic extract of asterina pectinifera inhibits LPS-induced inflammatory mediators in murine macrophage. Toxicol. Res., 26, 37-46. https://doi.org/10.5487/TR.2010.26.1.037
  15. Yang, E.J., Ham, Y.M., Lee, W.J., Lee, N.H. and Hyun, C.G. (2013) Anti-inflammatory effects of apo-9'-fucoxanthinone from the brown alga, Sargassum muticum. Daru, 21, 62. https://doi.org/10.1186/2008-2231-21-62
  16. Miyagaki, T., Asano, Y., Shibata, S., Ohno, Y., Tsunemi, Y., Saeki, H., Tamaki, K. and Sato, S. (2011) The development of Th1-mediated sarcoidosis improves the clinical course of Th2-mediated atopic dermatitis. Mod. Rheumatol., 21, 406-409. https://doi.org/10.3109/s10165-010-0404-5
  17. Levin, T.A., Ownby, D.R., Smith, P.H., Peterson, E.L., Williams, L.K., Ford, J., Young, P. and Johnson, C.C. (2006) Relationship between extremely low total serum IgE levels and rhinosinusitis. Ann. Allergy Asthma Immunol., 97, 650-652. https://doi.org/10.1016/S1081-1206(10)61095-2
  18. de Vries, I.J., Langeveld-Wildschut, E.G., van Reijsen, F.C., Bihari, I.C., Bruijnzeel-Koomen, C.A. and Thepen, T. (1997) Nonspecific T-cell homing during inflammation in atopic dermatitis: expression of cutaneous lymphocyte-associated antigen and integrin ${\alpha}$E${\beta}$7 on skin-infiltrating T cells. J. Allergy Clin. Immunol., 100, 694-701. https://doi.org/10.1016/S0091-6749(97)70175-1
  19. Debes, G.F., Bonhagen, K., Wolff, T., Kretschmer, U., Krautwald, S., Kamradt, T. and Hamann, A. (2004) CC chemokine receptor 7 expression by effector/memory $CD4^+$ T cells depends on antigen specificity and tissue localization during influenza A virus infection. J. Virol., 78, 7528-7535. https://doi.org/10.1128/JVI.78.14.7528-7535.2004
  20. Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G. and Glimcher, L.H. (2000) A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell, 100, 655-669. https://doi.org/10.1016/S0092-8674(00)80702-3
  21. Zheng, W. and Flavell, R.A. (1997) The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell, 89, 587-596. https://doi.org/10.1016/S0092-8674(00)80240-8
  22. Schwartz, L.B. (2004) Effector cells of anaphylaxis: mast cells and basophils. Novartis Found. Symp., 257, 65-74.
  23. Stone, K.D., Prussin, C. and Metcalfe, D.D. (2010) IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol., 125, S73-S80. https://doi.org/10.1016/j.jaci.2009.11.017
  24. Singer, P.A., McEvilly, R.J., Noonan, D.J., Dixon, F.J. and Theofilopoulos, A.N. (1986) Clonal diversity and T-cell receptor ${\beta}$-chain variable gene expression in enlarged lymph nodes of MRL-lpr/lpr lupus mice. Proc. Natl. Acad. Sci. U.S.A., 83, 7018-7022. https://doi.org/10.1073/pnas.83.18.7018

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