한국식품영양과학회지 (Journal of the Korean Society of Food Science and Nutrition)

  • 제45권6호
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  • Pages.903-910
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  • 2016
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  • 1226-3311(pISSN)
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  • 2288-5978(eISSN)
한국식품영양과학회 (The Korean Society of Food Science and Nutrition)
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천연소재 MS-10의 에스트로겐 수용체 조절을 통한 여성건강 증진

Natural Substance MS-10 Improves Women's Health via Regulation of Estrogen Receptor

  • 노유헌 (중앙대학교 의과대학 해부학교실) ;
  • 이지원 (중앙대학교 의과대학 비뇨기과학교실) ;
  • 박지애 (단국대학교 자연과학대학 식품영양학과) ;
  • 이상형 (서울대학교 의과대학 신경외과학교실) ;
  • 이준영 (서울대학교 의과대학 정신건강의학과교실) ;
  • 김성수 (단국대학교 자연과학대학 식품영양학과) ;
  • 박광균 (연세대학교 치과대학 구강생물학교실) ;
  • 김태진 (성균관대학교 의과대학 분자세포생물학교실) ;
  • 명순철 (중앙대학교 의과대학 비뇨기과학교실) ;
  • 정윤화 (단국대학교 자연과학대학 식품영양학과)
  • Noh, Yoo-Hun (Department of Anatomy and Cell Biology, College of Medicine, Chung-Ang University) ;
  • Lee, Ji Won (Department of Urology, College of Medicine, Chung-Ang University) ;
  • Park, Jiae (Department of Food Science and Nutrition, College of Natural Science, Dankook University) ;
  • Lee, Sang Hyung (Department of Neurosurgery, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University) ;
  • Lee, Jun Young (Department of Neuropsychiatry, SMG-SNU Borame Medical Center, College of Medicine, Seoul National University) ;
  • Kim, Sung-Su (Department of Food Science and Nutrition, College of Natural Science, Dankook University) ;
  • Park, Kwang-Kyun (Department of Oral Biology, College of Dentistry, Yonsei University) ;
  • Kim, Tae Jin (Department of Molecular Cell Biology and Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine) ;
  • Myung, Soon-Chul (Department of Urology, College of Medicine, Chung-Ang University) ;
  • Jeong, Yoonhwa (Department of Food Science and Nutrition, College of Natural Science, Dankook University)
  • 투고 : 2016.02.04
  • 심사 : 2016.02.17
  • 발행 : 2016.06.30
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초록

엉겅퀴와 타임의 복합추출물인 MS-10이 여성호르몬 수용체를 가역적으로 활성화해 여성갱년기에 감소하는 에스트로겐이 효율적으로 사용될 수 있도록 작용한다는 것이 확인되었다. 12주간의 인체적용시험에서 MS-10은 안면홍조 및 야한증, 감각마비, 수면장애, 신경과민, 우울, 현기증, 피로, 관절 및 근육통, 두통, 가슴 두근거림(심계항진), 그리고 질건조 등의 여성갱년기 증상이 개선되었음이 확인되었다. 이러한 MS-10의 여성갱년기 증상 개선은 MS-10에 의한 insulin-like growth factor-1의 개선에 기인한 것으로 판단된다. MS-10은 여성갱년기 증상을 개선하는 천연소재 건강 기능식품으로 사용될 수 있다.

In this study, the expression level of estrogen receptor in an ovariectomized rat model was effectively enhanced by MS-10, Cirsium japonicum and Thymus vulgaris extract complex, in a reversible manner. MS-10 plays a positive role in enhancing estrogen activity at low concentrations, leading to improved women's health. In order to determine whether or not MS-10 improves menopausal symptoms clinically, a randomized, double-blinded, and placebo-controlled clinical study was carried out on 62 middle-aged women treated with 500 mg of MS-10 or placebo daily for 12 weeks. Clinical menopausal symptoms were evaluated by Kupperman's index (KI) detecting various menopausal symptoms, including hot flushes, parenthesis, insomnia, nervousness, melancholia, dizziness, fatigue, rheumatic pain, palpitations, formication, and headaches. Total KI score decreased significantly by about 18% upon ingestion of MS-10. Colpoxerosis, a main symptom of menopause, was significantly reduced by about 21% upon ingestion of MS-10 in contrast to placebo. In addition, reduction of insulin-like growth factor-1 with age was improved by over 10% upon ingestion of MS-10, whereas there were no significant difference with placebo. No side effects appeared after treatment with MS-10. Thus, MS-10 can be suggested as a plausible natural substance for improving women's health.

키워드

참고문헌

  1. Enns DL, Tiidus PM. 2010. The influence of estrogen on skeletal muscle: sex matters. Sports Med 40: 41-58. https://doi.org/10.2165/11319760-000000000-00000
  2. Nilsson N, Carlsten H. 1994. Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation. Cell Immunol 158: 131-139. https://doi.org/10.1006/cimm.1994.1262
  3. Saint-Criq V, Rapetti-Mauss R, Yusef YR, Harvey BJ. 2012. Estrogen regulation of epithelial ion transport: Implications in health and disease. Steroids 77: 918-923. https://doi.org/10.1016/j.steroids.2012.02.017
  4. Iwakura A, Luedemann C, Shastry S, Hanley A, Kearney M, Aikawa R, Isner JM, Asahara T, Losordo DW. 2003. Estrogen-mediated, endothelial nitric oxide synthase-dependent mobilization of bone marrow-derived endothelial progenitor cells contributes to reendothelialization after arterial injury. Circulation 108: 3115-3121. https://doi.org/10.1161/01.CIR.0000106906.56972.83
  5. Oboti L, Ibarra-Soria X, Perez-Gomez A, Schmid A, Pyrski M, Paschek N, Kircher S, Logan DW, Leinders-Zufall T, Zufall F, Chamero P. 2015. Pregnancy and estrogen enhance neural progenitor-cell proliferation in the vomeronasal sensory epithelium. BMC Biol 13: 104. https://doi.org/10.1186/s12915-015-0211-8
  6. Cummings SR, Rubin SM, Black D. 1990. The future of hip fractures in the United States. Numbers, costs, and potential effects of postmenopausal estrogen. Clin Orthop Relat Res 1: 163-166.
  7. Holloway D. 2011. An overview of the menopause: assessment and management. Nurs Stand 25: 47-57. https://doi.org/10.7748/ns.25.23.47.s52
  8. Nappi RE, Kokot-Kierepa M. 2010. Women's voices in the menopause: results from an international survey on vaginal atrophy. Maturitas 67: 233-238. https://doi.org/10.1016/j.maturitas.2010.08.001
  9. Chakrabarti S, Morton JS, Davidge ST. 2014. Mechanisms of estrogen effects on the endothelium: an overview. Can J Cardiol 30: 705-712. https://doi.org/10.1016/j.cjca.2013.08.006
  10. Harlow SD, Gass M, Hall JE, Lobo R, Maki P, Rebar RW, Sherman S, Sluss PM, de Villiers TJ. 2012. Executive summary of the Stages of Reproductive Aging Workshop + 10: addressing the unfinished agenda of staging reproductive aging. J Clin Endocrinol Metab 97: 1159-1168. https://doi.org/10.1210/jc.2011-3362
  11. Hooper L, Ryder JJ, Kurzer MS, Lampe JW, Messina MJ, Phipps WR, Cassidy A. 2009. Effects of soy protein and isoflavones on circulating hormone concentrations in preand post-menopausal women: a systematic review and metaanalysis. Hum Reprod Update 15: 423-440. https://doi.org/10.1093/humupd/dmp010
  12. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R, Strickland OL, Wong ND, Crouse JR, Stein E, Cushman M. 2003. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 349: 523-534. https://doi.org/10.1056/NEJMoa030808
  13. Simon JA, Hunninghake DB, Agarwal SK, Lin F, Cauley JA, Ireland CC, Pickar JH. 2001. Effect of estrogen plus progestin on risk for biliary tract surgery in postmenopausal women with coronary artery disease: the Heart and Estrogen/progestin Replacement Study. Ann Intern Med 135: 493-501. https://doi.org/10.7326/0003-4819-135-7-200110020-00008
  14. Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. 1998. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 280: 605-613. https://doi.org/10.1001/jama.280.7.605
  15. Brinton LA, Richesson D, Leitzmann MF, Gierach GL, Schatzkin A, Mouw T, Hollenbeck AR, Lacey JV Jr. 2008. Menopausal hormone therapy and breast cancer risk in the NIH-AARP Diet and Health Study Cohort. Cancer Epidemiol Biomarkers Prev 17: 3150-3160. https://doi.org/10.1158/1055-9965.EPI-08-0435
  16. Noh YH, Kim DH, Lee SA, Yin XF, Park J, Lee MY, Lee WB, Lee SH, Kim JK, Kim SS, Jeong Y, Myung SC, Kim TJ, Kang IJ. 2016. The natural substance MS-10 improves and prevents menopausal symptoms, including colpoxerosis, in clinical research. J Med Food 19: 228-237. https://doi.org/10.1089/jmf.2015.3547
  17. Choi YJ, Yoon Y, Choi HS, Park S, Oh S, Jeong SM, Suh HR, Lee BH. 2011. Effects of medicinal herb extracts and their components on steatogenic hepatotoxicity in Sk-hep1 cells. Toxicol Res 27: 211-216. https://doi.org/10.5487/TR.2011.27.4.211
  18. de la Peña JB, Kim CA, Lee HL, Yoon SY, Kim HJ, Hong EY, Kim GH, Ryu JH, Lee YS, Kim KM, Cheong JH. 2014. Luteolin mediates the antidepressant-like effects of Cirsium japonicum in mice, possibly through modulation of the GABAA receptor. Arch Pharm Res 37: 263-269. https://doi.org/10.1007/s12272-013-0229-9
  19. Liu S, Luo X, Li D, Zhang J, Qiu D, Liu W, She L, Yang Z. 2006. Tumor inhibition and improved immunity in mice treated with flavone from Cirsium japonicum DC. Int Immunopharmacol 6: 1387-1393. https://doi.org/10.1016/j.intimp.2006.02.002
  20. Yin J, Heo SI, Wang MH. 2008. Antioxidant and antidiabetic activities of extracts from Cirsium japonicum roots. Nutr Res Pract 2: 247-251. https://doi.org/10.4162/nrp.2008.2.4.247
  21. Büechi S, Vögelin R, von Eiff MM, Ramos M, Melzer J. 2005. Open trial to assess aspects of safety and efficacy of a combined herbal cough syrup with ivy and thyme. Forsch Komplementarmed Klass Naturheilkd 12: 328-332. https://doi.org/10.1159/000088934
  22. de la Torre Rodriguez YC, Martínez Estrada FR, Flores Suarez AE, Waksman de Torres N, Salazar Aranda R. 2013. Larvicidal and cytotoxic activities of extracts from 11 native plants from northeastern Mexico. J Med Entomol 50: 310-313. https://doi.org/10.1603/ME12056
  23. Gruenwald J, Graubaum HJ, Busch R. 2006. Evaluation of the non-inferiority of a fixed combination of thyme fluidand primrose root extract in comparison to a fixed combination of thyme fluid extract and primrose root tincture in patients with acute bronchitis. Arzneimittelforschung 56: 574-581.
  24. Shimelis ND, Asticcioli S, Baraldo M, Tirillini B, Lulekal E, Murgia V. 2012. Researching accessible and affordable treatment for common dermatological problems in developing countries. An Ethiopian experience. Int J Dermatol 51: 790-795. https://doi.org/10.1111/j.1365-4632.2011.05235.x
  25. Walker JM. 1994. The bicinchoninic acid (BCA) assay for protein quantitation. Methods Mol Biol 32: 5-8.
  26. Kupperman HS, Blatt MH, Wiesbader H, Filler W. 1953. Comparative clinical evaluation of estrogenic preparations by the menopausal and amenorrheal indices. J Clin Endocrinol Metab 13: 688-703. https://doi.org/10.1210/jcem-13-6-688
  27. Chae HD, Choi SY, Cho EJ, Cho YM, Lee SR, Lee ES, Park HM. 2014. Awareness and experience of menopausal symptom and hormone therapy in Korean postmenopausal women. J Menopausal Med 20: 7-13. https://doi.org/10.6118/jmm.2014.20.1.7
  28. Filus A, Zdrojewicz Z. 2015. Insulin-like growth factor-1(IGF-1)-structure and the role in the human body. Pediatr Endocrinol Diabetes Metab 20: 161-169.
  29. Froesch ER, Schmid C, Schwander J, Zapf J. 1985. Actions of insulin-like growth factors. Ann Rev Physiol 47: 443-467. https://doi.org/10.1146/annurev.ph.47.030185.002303
  30. Zapf J, Schoenle E, Froesch ER. 1978. Insulin-like growth factors I and II: some biological actions and receptor binding characteristics of two purified constituents of nonsuppressible insulin-like activity of human serum. Eur J Biochem 87: 285-296. https://doi.org/10.1111/j.1432-1033.1978.tb12377.x
  31. Juul A, Holm K, Kastrup KW, Pedersen SA, Michaelsen KF, Scheike T, Rasmussen S, Muller J, Skakkebaek NE. 1997. Free insulin-like growth factor I serum levels in 1430 healthy children and adults, and its diagnostic value in patients suspected of growth hormone deficiency. J Clin Endocrinol Metab 82: 2497-2502.
  32. Lin CM, Huang YL, Lin ZY. 2009. Influence of gender on serum growth hormone, insulin-like growth factor-I and its binding protein-3 during aging. Yonsei Med J 50: 407-413. https://doi.org/10.3349/ymj.2009.50.3.407
  33. Kwon JY, Nam TJ. 2005. Effects of phytoestrogen on cell growth and insulin-like growth factor-I (IGF-I) production in MC3T3-E1 cells. J Korean Soc Food Sci Nutr 34: 743-749. https://doi.org/10.3746/jkfn.2005.34.6.743
  34. Alonso A, Gonzalez C. 2012. Neuroprotective role of estrogens: relationship with insulin/IGF-1 signaling. Front Biosci (Elite Ed) 4: 607-619.
  35. Sheng MH, Lau KH, Baylink DJ. 2014. Role of osteocytederived insulin-like growth factor I in developmental growth, modeling, remodeling, and regeneration of the bone. J Bone Metab 21: 41-54. https://doi.org/10.11005/jbm.2014.21.1.41

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  1. Flavonoids from Cirsium japonicum var. maackii pappus as inhibitors of aldose reductase and their simultaneous determination 2018, https://doi.org/10.1007/s11696-017-0259-8
  2. Cirsium japonicum var. maackii and apigenin block Hif‐2α‐induced osteoarthritic cartilage destruction vol.23, pp.8, 2016, https://doi.org/10.1111/jcmm.14418
  3. Safety Assessment of Endocrine Disruption by Menopausal Health Functional Ingredients vol.9, pp.10, 2021, https://doi.org/10.3390/healthcare9101376