Progress in Medical Physics (한국의학물리학회지:의학물리)

Korean Society of Medical Physics (한국의학물리학회)
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Analysis of Physical Properties for Various Compositions of Reusable LMG and LCV Micelle Gel

  • Kang, Jin Mook (Korea Institute of Radiological and Medical Sciences) ;
  • Lee, Dong Han (Korea Institute of Radiological and Medical Sciences) ;
  • Cho, Yu Ra (Korea Institute of Radiological and Medical Sciences) ;
  • Hwang, Seon Bung (Korea Institute of Radiological and Medical Sciences) ;
  • Ji, Young Hoon (Korea Institute of Radiological and Medical Sciences) ;
  • Ahn, So Hyun (Department of Radiation Oncology, Yonsei University College of Medicine) ;
  • Keum, Ki Chang (Department of Radiation Oncology, Yonsei University College of Medicine) ;
  • Lee, Re Na (Department of Radiation Oncology, Ewha Womans University College of Medicine) ;
  • Cho, Sam Ju (Department of Radiation Oncology, Ewha Womans University College of Medicine) ;
  • Noh, Insup (Department of Chemical and Biomolecular Engineering, Seoul National University)
  • Received : 2016.11.10
  • Accepted : 2016.11.25
  • Published : 2016.12.31
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Abstract

In this study, we evaluated the reusable leuco malachite green (LMG) micelle gel properties dependent on various components of chemical concentration and compared with leuco crystal violet (LCV). The gels were delivered to 10, 20, 30, 40 and 50 Gy at 6 MV photon beam from linear accelerator and analyzed using spectrophotometry. We confirmed that the reusable LMG and LVC absorbance wavelength peak were made up at 630 nm and 600 nm respectively. The transparency of reusable LMG decreased with higher amount of trichloroacetic acid (TCAA) and lower reusable LMG dyes. 1 mM reusable LMG was the lowest transparency. The sensitivity was increased depending on lower trichloroacetic acid (TCAA) concentrations and the amount of suitable surfactant (Triton X-100), which was found to be 7 mM. However, we were not able to investigate sensitivity effects factor from reusable LMG dyes. The gel dosimeter containing 16 mM TCAA, 7 mM Triton X-100 gel dosimeter showed the highest sensitivity at $0.0021{\pm}0.0001cm^{-1}.Gy^{-1}$. The sensitivity of LCV was found to be higher than reusable LMG at $0.0037{\pm}0.0005cm^{-1}.Gy^{-1}$. The reusable LMG and LCV dose responses were shown to be $R^2=0.997$, $R^2=0.999$ respectively, as stable measurement results. Future research is necessary to improve dose sensitivity, dose rate dependency and gel fading with extensive chemical formulations.

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References

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