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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Translational control of mRNAs by 3'-Untranslated region binding proteins

  • Yamashita, Akio (Department of Molecular Biology, Yokohama City University School of Medicine) ;
  • Takeuchi, Osamu (Laboratory of Infection and Prevention, Institute for Frontier Life and Medical Sciences, Kyoto University)
  • Received : 2017.03.08
  • Published : 2017.04.30
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Abstract

Eukaryotic gene expression is precisely regulated at all points between transcription and translation. In this review, we focus on translational control mediated by the 3'-untranslated regions (UTRs) of mRNAs. mRNA 3'-UTRs contain cis-acting elements that function in the regulation of protein translation or mRNA decay. Each RNA binding protein that binds to these cis-acting elements regulates mRNA translation via various mechanisms targeting the mRNA cap structure, the eukaryotic initiation factor 4E (eIF4E)-eIF4G complex, ribosomes, and the poly (A) tail. We also discuss translation-mediated regulation of mRNA fate.

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