Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Evaluation on Skin Irritation of Bee Venom in Human

봉독의 인체 피부자극성 평가

  • Han, Eun-Hye (Research and Development Center, Koreaeundan) ;
  • Lim, Mi-Kyung (Research and Development Center, Koreaeundan) ;
  • Lee, Sang Ho (Research and Development Center, Koreaeundan) ;
  • Park, Keun-Tae (Department of Research and Development Center, Milae Resources ML Co. Ltd.) ;
  • Park, Ji-eun (Department of Public Health Science (BK21PLUS Program), Graduate School, Korea University) ;
  • Lim, Young-Hee (Department of Public Health Science (BK21PLUS Program), Graduate School, Korea University) ;
  • Sim, Insuk (Department of Integrated Biomedical and Life Sciences, College of Health Science, Korea University)
  • 한은혜 (고려은단 R&D부) ;
  • 임미경 (고려은단 R&D부) ;
  • 이상호 (고려은단 R&D부) ;
  • 박근태 ((주)미래자원 ML 신소재 연구소) ;
  • 박지은 (고려대학교 보건과학과(BK21 PLUS Program)) ;
  • 임영희 (고려대학교 보건과학과(BK21 PLUS Program)) ;
  • 심인숙 (고려대학교 의생명융합과학과)
  • Received : 2017.08.25
  • Accepted : 2017.09.22
  • Published : 2017.09.30
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Abstract

The purpose of this study was to investigate the skin irritation of bee venom (melittin) in human. Skin irritation test was performed at 0.05% bee venom by 48 h single patch test in 30 healthy volunteers with no skin disease and skin sensitization test was performed by local lymph node assay in animal. In single patch test, 28 human subjects showed no reaction and 2 subjects showed 1+ or 3+ grade skin reaction. In a skin sensitization test of bee venom conducted using mice. no erythema was observed on the dorsal side of mice up to 8 days after application of bee venom on the skin. The results of the average stimulation index by ATP values showed that there was no irritation to the mice skin at 0.005% and 0.01% of bee venom. Therefore, bee venom is not likely to induce a significant skin irritation under 0.05% concentration.

Keywords

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