Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Immunomodulatory Effects of an Extract from Pinus koraiensis Cone Peel in LP-BM5 Murine Leukemia Viruses-Induced Murine Acquired Immune Deficiency Syndrome

면역 결핍 동물모델에서 잣피 추출물의 면역조절 효과

  • Kim, Seong Pil (Department of Gerontology, Kyung Hee University) ;
  • Kwon, Han Ol (Department of Medical Nutrition, Kyung Hee University) ;
  • Ha, Yejin (Department of Medical Nutrition, Kyung Hee University) ;
  • Heo, Seok Hyun (Korea Health Supplements Association) ;
  • Lee, Jeongmin (Department of Medical Nutrition, Kyung Hee University)
  • 김성필 (경희대학교 동서의학대학원 노인학과) ;
  • 권한올 (경희대학교 동서의학대학원 의학영양학과) ;
  • 하예진 (경희대학교 동서의학대학원 의학영양학과) ;
  • 허석현 (한국건강기능식품협회) ;
  • 이정민 (경희대학교 동서의학대학원 의학영양학과)
  • Received : 2017.06.21
  • Accepted : 2017.08.26
  • Published : 2017.09.30
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Abstract

The immune system is a complex process within the body that protects against disease. Recently, many studies have attempted to discover immunomodulative compounds from natural sources. Pinus koraiensis (PK) cone shell is a by-product of PK. One of the major compounds of PK cone shell is dehydroabietic acid, which has bioactivity, including antiulcer and anti-inflammatory activities. Therefore, this study was performed to examine the immunomodulative effects of PK cone shell. The immunomodulatory effects of PK cone shell extracted with 20% ethanol (EtOH) in vivo were examined initially by measuring the natural killer (NK) cell activity, phagocytic activity, Th1/Th2 cytokines release, serum immunoglobulin, and T/B cell proliferation. The NK cell activity and phagocytic activity were increased significantly by a treatment with a 20% EtOH extract of PK cone shell. Th1 type cytokine and T cell proliferation increased and Th2 type cytokine, B cell proliferation and serum immunoglobulin A, G, and E decreased after a treatment with PK cone shell extract. The 20% EtOH extract of the PK cone shell normalized the unbalanced production of Th1/Th2 type cytokine. This suggests that a 20% EtOH extract of PK cone shell has great potential as a health food.

본 연구에서는 잣피 20% 주정 추출물을 첨가한 식이로 하여 바이러스에 감염되어 면역력이 결핍된 마우스에서 면역조절 효과를 확인하고자 T, B 세포의 증식능, Th1 type cytokine과 Th2 type cytokine, NK cell activity, phagocytic activity를 확인하였다. 바이러스로 인하여 AIDS와 유사하게 면역 결핍된 마우스 모델에서 cytokine의 불균형과 T 세포와 B 세포의 proliferation이 균형적으로 회복됨을 확인하였고 바이러스로 인해 자연살해세포와 대식세포의 활성능이 감소하였지만 잣피 20% 주정 추출물의 공급 시 활성능 회복에 도움을 주는 것을 확인하였다. 따라서 잣피 20% 주정 추출물은 LP-BM5 virus로 유도한 면역 결핍 마우스 모델에서 면역조절작용에 효능이 있음을 확인하였다.

Keywords

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