Herbal Formula Science (대한한의학방제학회지)

The Korean Medicine Society for the Herbal Formula Study (대한한의학방제학회)
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Analysis for Compatibility of Daehwangmokdan-tang and Its Pharmacological Activities

대황목란탕(大黃牧丹湯)의 배오(配伍)분석과 그 약리활성

  • Kim, Do Hoy (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University) ;
  • Yoon, Michung (Division of Medical Engineering and Health Management, Mok-Won University) ;
  • Shin, Soon Shik (Department of Formula Sciences and Research Center of Korean Medicine for Diabetes and Obesity, College of Korean Medicine, Dong-Eui University)
  • 김도회 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소) ;
  • 윤미정 (목원대학교 의생명.보건학부) ;
  • 신순식 (동의대학교 한의과대학 방제학교실 및 한방당뇨비만연구소)
  • Received : 2018.02.04
  • Accepted : 2018.02.24
  • Published : 2018.02.28
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Abstract

Objectives : I analysed daehwangmokdan-tang's compatibility principle by the system of chief, deputy, assistant, and envoy and investigated pharmacological activities by categorizing with chemical components, molecular level, cellular level, animal level and human level based on Korean and Chinese studies for this formula. Methods : Daehwangmokdan-tang's compatibiltity principle was examined by the system of chief, deputy, assistant, and envoy. I looked into studies that presented in Korea from 1956 to 2016 about daehwangmokdan-tang through KOREA INSTITUTE OF ORIENTAL MEDICINE, Korean medicine information system (OASIS) and in Chinese for 20 years about daehwangmokdan-tang through China National Knowledge Infrastructure, CNKI. Then classify into chemical components, molecular level, cellular level, animal level and human level to analyse. Results : According to the system of chief, deputy, assistant, and envoy, chief herb is Rhei Radix et Rhizoma and Moutan Cortex, deputy herb is Natrii Sulfas and Persicae Semen, assistant and envoy herbs are Trichosanthis Semen. The amount of extraction of paeonol, total anthraquinone, and conjugated anthraquinone from daehwangmokdan-tang with the formulation of the system of chief, deputy, assistant, and envoy was the highest, and in the formulation of chief herb and deputy herb, the extraction amount of paeonol and conjugated anthraquinone was the lowest. With other formulations, the amount of extraction of total anthraquinone and conjugated anthraquinone was improved, although the degree was different. In particular, when it is blended with Persicae Semen as a deputy herb, the extraction amount of total anthraquinone and conjugated anthraquinone of Rhei Radix et Rhizoma as a chief herb is greatly increased, and the extraction amount of paeonol is rather different, but it is lowered. It was found that the amount of Mg Ca K Na in daehwangmokdan-tang was the highest. Pharmacological activities can be detected in inflammatory mediators and enzymes for molecular level. For cellular level, it can be determined in lipopolysaccharide (LPS)-stimulated RAW 264.7 cell line. In mouse and rats for animal level and human level, in inflammatory diseases (acute appendicitis, acute pancreatitis, acute cholecystitis, acute abdominal disease, ect.), pharmacological activities was caught. Conclusions : From the above results, daehwangmokdan-tang is composed in line with the system of chief, deputy, assistant, and envoy, suggesting that there is certain rationality and scientific. Pharmacological activities of daehwangmokdan-tang are effective to anti-inflammation, improvement of sepsis, analgesic, muscle relaxation, and improvement of intestinal flora and its metabolites. Daehwangmokdan-tang is consistent with the action of diuresis and anti-inflammation in terms of the content of elements, suggesting that there is action of purging fire and removing blood stasis, defecation detoxification, cooling blood and clearing heat and activating blood and dispersing stasis.

Keywords

References

  1. Chen Ji Fan. Synopsis of the Golden Chamber. first edition. Beijing: People's Medical Publishing House, 2000: 626-631.
  2. Qing Xuan Gong. Liu Juanzi's Ghost-Bequeathed Prescriptions. Beijing: Zhong Hua Book Company, 1985: 31.
  3. The National Library Branch. Peaceful Holy Benevolent Prescriptions(Volume 80). The Secretary of Chinese ancient doctors really works(Volume 29). Beijing: National Library Documents microfilm Center, 2004: 5136.
  4. Shao Zhu ect. Prescriptions for Universal Relief(Volume 8). Seoul: Euiseongdang Publishing Co., 1993: 395.
  5. Jangwon Mun. Korean translation on The Great Compendium of External Medicine. Graduate school of Dongeui University. Master's dissertation in Korean medicine, 2002: 360.
  6. Compiled by Xian Zhong Wu. Modern research and application of Chengqi Decoction. first edition. Beijing: People's Medical Publishing House, 2011: 333-335.
  7. Kim Do Hoy, Seo Bu-il, Kim Bo Kyung, Kim Gyeong Cheol, Shin Soon Shik. Standard Principles for the Designing of Prescriptions - The Theory for Monarch, Minister, Adjuvant and Dispatcher. The Korean Journal of Oriental Medical Prescription. 2003; 11(2): 1-18.
  8. https://oasis.kiom.re.kr
  9. http://gb.oversea.cnki.net/Kns55
  10. Zhong Yuan Chai, Sen Kang Sun. Understanding for “melon seeds” among the classical prescriptions. Henan Traditional Chinese Medicine. 1983;5:18.
  11. Heo Jun author; the literature research institute of eastern medicine translation; Jin Jupyo notes. New translation of Treasured Mirror of Eastern Medicine. revised edition. Seoul: BUBIN PUBLISHERS CO., 2009: 1502.
  12. Liu Xue Wen, Tang Qing Xiang. Formula Solutions and Taste Memory. first edition. Shenyang: Liaoning Science and Technology Publishing House, 1999: 25-26.
  13. Compiled by Dun Bao Sheng. Shorthand Encyclopedia for Practical Formula. first edition. Xian: World Publishing Company, Xi'an, 2001: 47.
  14. Xie Ming. Formula Science. first edition. Beijing: People's Medical Publishing House, 2002: 463-464.
  15. Compiled by Liu Gong Wang. Formula Science. first edition. Beijing: Huaxia Publishing House, 2002: 339.
  16. Zhang Min Qing. Modern Clinical Formula Science. first edition. Beijing: People's Medical Publishing House, 2004: 834-835.
  17. Qiu De Wen, Feng Yong, Zou Ke Yang. Modern Formula Science. first edition. Beijing: Traditional Chinese Medicine Classics Press, 2006: 89-90.
  18. Ni Cheng. New Edited Formula Science. first edition. Beijing: People's Medical Publishing House, 2006: 581-583.
  19. Li Fei. Formula Science(Volume 1). 2nd edition. Beijing: People's Medical Publishing House, 2011: 276.
  20. Xian Yang Wang. Effect of different compatibility of dahuang mudan decoction on effective ingredients. Chinese Journal of Traditional Medical Science and Technology. 2002;9(3):161-162.
  21. Zi Ren Su, Yuan Er Zeng, Hua Zhou ect. Preliminary study on chemical changes in the process of rhubarb decocting. China Journal of Chinese Materia Medica. 1999;24(5):291.
  22. Zi Ren Su, Jian Nan Chen. Study on the physical and chemical changes in the process of traditional Chinese medicine preparation. China Journal of Chinese Materia Medica. 1998;23(11):671.
  23. Li Liu, Cao Yan, Jun Jiang, Chun Jie Zhao. Determination of 11 elements in dahuang mudan decoction by Flame Atomic Absorption Spectrometry. Herald of Medicine. 2011;30(8):1080-1083.
  24. Sheng Li Chen. Effect of dahuangmudan Decoction on inflammatory factors in patients with chronic appendicitis. Journal of Military Surgeon in Southwest China. 2015;17(4):411-412.
  25. SUN Yan-ni, CHENG Jie-jing, YANG Xiao-yan, YANG Jie, WANG Li-min, LIU Jun. Effect of Dahuang Mudan decoction-contained serum on the expression of TLR4 and MyD88 in lipopolysaccharide-stimulated pulmonary macrophages of rats. Shandong Medical Journal. 2014;54(10):10-13.
  26. LIU Jun, CHENG Jiejing, YANG Xiaoyan, YANG Jie, WANG Limin, SUN Yanni. Effects of Dahuangmudan Tang Drug Serum on Expression of TRIF and TRAM in Lipopolysaccharide-Stimulated RAW 264.7 Murine Macrophages. Chinese Journal of Clinical Medicine. 2014;21(2):122-125.
  27. ZHENG Yanyi, WEN Ruyan, LUO Xia, ZHOU Lian. In-vitro Effect of Dahuang Mudan Decoction on Intestinal Flora. Journal of Guangzhou University of Traditional Chinese Medicine. 2016;33(3):357-361.
  28. Da Xing Miao, Tian Bao Xiao, Yuan Ling Liang. Effect of drug serum containing Dahuang Mudan Decoction on the release of inflammatory factors in macrophages. Lishizhen Medicine and Materia Medica Research. 2014;25(4):843-845.
  29. WANG Qing, ZHOU Chen-mei, ZHOU Lian, CAO Liu-ying, LIANG Rui-yan, WANG Pei-xun. The Effect ofDahuang Mudan Decoction on Serum Cytokine Levels in Experimental Colitis Mice. Progress in Modern Biomedicine. 2007;7(12):1791-1793.
  30. ZHENG Dongsheng, WANG Lihong, DENG Xiangliang, ZHOU Lian. Therapeutic Effect and Mechanism of Alcohol Extract from Dahuang Mudan Decoction on Colitis Mice Induced by Trinitrobenzene Sulfonic Acid. Traditional Chinese Drug Research and Clinical Pharmacology. 2013;24(3):226-230.
  31. ZHANG Yan-ying, SHU Chang, CAI Xing, WU Jian-jun, ZHANG Yan-xia, WANG Rong, LI Cun-xiang, KANG Wan-rong, WANG Rong. The Effect of Dahuang Mudan Decoction on Inflammatory Response and Oxidative Stress in Acute Pancreatitis Model Rats. Laboratory Animal Science. 2014;31(5):24-27.
  32. ZHANG Yan-xia, ZHANG Yan-ying, SHU Chang, CAI Xing, WU Jian-jun, LI Cun-xiang, KANG Wan-rong. Protective effect of Dahuang Mudan Decoction on acute pancreatitis in rats. Traditional Chinese Medicinal Research. 2015;28(2):55-58.
  33. WEN Ruyan, LUO Xia, ZHENG Yanyi, ZHOU Lian, LUO Shuang. Therapeutic Effect of Dahuang Mudan Decoction for Murine Ulcerative Colitis Induced by Dextran Sulfate Sodium. Traditional Chinese Drug Research & Clinical Pharmacology. 2016;27(5):649-654.
  34. WEN Ruyan, LUO Xia, ZHENG Yanyi, ZHOU Lian, LIAO Haifeng, LIU Qi. Rhubarb Peony Decoction Ameliorate DSS-induced Ulcerative colitis and It's Associated Anemia in Mice. Chinese Archives of Traditional Chinese Medicine. Chinese Archives of Traditional Chinese Medicine. 2016;34(12):2998-3001.
  35. Joong Bae Kim, Gyoo Yong Ghi, Hyun Sup Eom. Effects of Daehwangmudan-tang on Urate Lowering and Detection of Relevant Genes. Korean J. Oriental Physiology & Pathology. 2005;19(6):1534-1540.
  36. Hyun Sup Eom. Effects of Gami-Daehwangmokdan-tang on the Gout Induced ICR Mice. Korean J. Oriental Physiology & Pathology. 2007;21(2):399-403.
  37. Sung-Joo Park, Jong-Gil Jeong, Sang-Wan Seo, Sang-Wook Hwang, Yong-Woo Kim, Dal-Soo Song, Young-Seok Chae, Min-Kyo Shin, Ho-Joon Song. Effects of Gami-Daehwangmokdanpi-Tang against CCK-induced acute pancreatitis. Korean Journal of Herbology. 2005;20(3):59-65.
  38. Jae Sun Ahn, Hae Ja Lee, Eun Jung Park. Inhibitory effect of acute pancreatitis by Gagam-Daehwangmokdanpi-Tang. Korean Journal of Oriental Pediatrics. 2006;20(3):117-127.
  39. Sung-Bai Kim, Kyu-Sang Lim. Effects of Daehwangmockdanpitang(大黃牧丹皮湯) on Analgesic, Anti-inflammatory, Muscle Relaxation and Changes of Body Temperature through Experimental Animals. The Journal of Won Kwang Oriental Medicine. 1992;2(1):451-461.
  40. Sung-Bai Kim, Woo-Shin Ko, Kyu-Sang Lim. Effects of Rhei Rhizoma Cortex Moutan tang on laboratory animals for relieving the pain, anti-inflammatory action, sedation and normal body temperature. The Journal of Won Kwang Oriental Medicine. 1992;5(1):1-15.
  41. ZHOU Chenmei, WANG Qing, ZHOU Lian, CAO Liuying, LIANG Ruiyan, WANG Peixun. Effect of Dahuang Mudan Decoction on Mice Colitis Induced by Trinitrobenzene Sulfonic Acid. Traditional Chinese Drug Research & Clinical Pharmacology. 2007;18(4):263-265.
  42. XIE Yi, CUI Hualei, WANG Xiaoye, Dong Liang, WANG Zhenfang, GU Jiqing. Changes in the secretion of IL-1 and TNF in alveolar macrophages in rats with peritonitis and the regulating effect of Dahuang Mudan Decoction. Journal of Clinical Pediatric Surgery. 2007;6(2):44-45.
  43. WANG Qing, ZHOU Chen-mei, ZHOU Lian, CAO Liu-ying, LIANG Rui-yan, WANG Pei-xun. The Effect ofDahuang Mudan Decoction on Serum Cytokine Levels in Experimental Colitis Mice. Progress in Modern Biomedicine. 2007;7(12):1791-1793.
  44. Dong Ying, Cui Hualei, Wang Xiaoye, Dong Liang. Effect of "Dahuang Mudan(大黄牡丹) Decoction" Treatment on Plasma Tissue-type-Plasminogen Activator and Pasminogen Activator Inhibitor Levels in Rats with Peritoneal Adhesion. Chinese Journal of Surgery of Integrated Traditional and Western Medicine. 2011;17(1):69-72.
  45. ZHANG Yan-ying, SHU Chang, CAI Xing, WU Jian-jun, ZHANG Yan-xia, WANG Rong, LI Cun-xiang, KANG Wan-rong, WANG Rong. The Effect of Dahuang Mudan Decoction on Exocrine Function of Pancreatic Acinar Cells in Acute Pancreatitis Model Rats. Laboratory Animal Science. 2014;31(3):26-29.
  46. ZHANG Yanying, WANG Yongfeng, ZHANG Yanxia, LI Cunxiang, KANG Wanrong. Effects of Dahuang Mudan Decoction prescription on the pancreatic gland cell apoptosis in rats with acute pancreatitis. Jilin Journal of Traditional Chinese Medicine. 2014;34(10):982-984.
  47. PAN Jin-hong, ZHANG Yan-ying, WANG Yongfeng, WU Jian-jun, ZHANG Yan-xia, LI Cun-xiang, KANG Wan-rong. The Effect of Dahuang Mudan Decoction to Pancreatic Gland Microcirculation of Acute Pancreatitis Model Rat. Laboratory Animal Science. 2016;33(5):48-51.
  48. WANG G, WANG S Q, Y Z Y. The observation about the curative effect of integrated traditional and western medicine treatment to the acute dropsy pancreatitis. J Changchun Univ Tradit Chin Med. 2008;24(4):394-395.
  49. XU Zhipeng. Clinical Observation of Dahuang Mudan Decoction Clyster in the Treatment of Acute Pancreatitis. Modern Diagnosis & Treatment. 2013;24(9):1973-1975
  50. XING Youmei. Clinical effect analysis of Dahuang Mudan Decoction with retention enema in the treatment of acute pancreatitis. Journal of Emergency in Traditional Chinese Medicine. 2016;25(8):1634-1644.
  51. JIANG M H,WANG T H. The clinical observations to 23 cases about dispelling phlegm and dispelling ecchymosis therapy to treat the pancreatitis of pseudo cyst[J]. Chin J Tradit Med Sci Technol. 2006;13(2):129-130.
  52. CAO J T. 44 Cases about Dahuang Mudanpi Decoction to treat the acute cholecystitus. Henan Tradit Chin Med. 2008;28(2):16.
  53. ZHANG X W. 31 Cases about “DCHT”and Dahuang Mudan Decoction to treat gallstones. Jiangsu J Tradit Chin Med. 2003;24(1):20-21.
  54. HUANG Q, ZHAO G E, HUANG Y. Dahuang Mudanpi Decoction treats lung abcess [J]. Henan Tradit Chin Med. 2001;21(2):13.
  55. ZHANG W C, ZHAO H, NIU G D, et al. The curative effect observation about Dahuang Mudan Decoction and its relatives to treat the heavy hepatitis. Hubei J Tradit Chin Med. 2003;2(3):10.
  56. ZHANG H. The new 2 cases about Dahuang Mudan Decoction's clinical application[J]. Chin J Tradit Med. 2005;3(3):643.
  57. HU H Z. The 34 cases about Dahuang Mudan decoction and its relatives to treat ulcerous colitis. Liaoning J Tradit Chin Med. 2000;27(4):171.
  58. WANG Zhou, XIA Cangjun. The clinical observation of Dahuang Mudan decoction in treating 52 cases of early postoperative inflammatory ileus. Clinical Journal of Chinese Medicine. 2016;8(24):66-68.
  59. ZHANG Minying. Clinical observation of 53 cases of pancreatic derived intestinal obstruction treated by Dahuang Mudan decoction combined with Electroacupuncture. Jiangsu Journal of Traditional Chinese Medicine. 2016;48(11):60-61.
  60. ZHOU Z C, GAO Z D. The 15 cases about Dahuang Mudanpi Decoction to treat kidney syndrome hemorrhagic fever few urine period [J]. Shandong J Tradit Chin Med. 2000;l9(5):280-281.
  61. HUO G X. The clinical observation about Dahuang Mudan Decoction to treat the acute hemorrhagic stroke. Clin J Tradit Chin Med. 2005;l7(4):316-317.
  62. HE X Y. Dahuang Mudanpi Decoction and Yiyifuzibaijiang Decoction treat the chronic bacterial prostatitis. Henan Tradit Chin Med. 2002;22(3):14-15.
  63. ZHANG Yang, ZHANG Ping, LU Zijie, XU Yan, GU Xiaojian. Clinical observation of 30 cases of chronic prostatitis of type III B treated with the addition and subtraction of Dahuang Mudan decoction. Jiangsu Journal of Traditional Chinese Medicine. 2013;45(12):35-37.
  64. WANG P, REN H. The curative effect observation about integrated traditional and western medicine to treat the sole appendicitis. Acta Acad Med Zunyi. 2009;32(1):66-67.
  65. LIU Yunhong. 40 cases of acute appendicitis treated with Dahuang Mudan decoction plus. Yunnan Journal of Traditional Chinese Medicine and Materia Medica. 2010;31(4):85-86.
  66. YANG Jun, ZHANG Gangling, YANG Shuo, ZHANG Canwei, ZHU Yufeng. Clinical observation of 108 cases of acute appendicitis treated with Dahuang Mudan decoction plus combined with Western Medicine. Contemporary Medicine. 2011;17(35):145-146.
  67. YANG Cheng. Study of Laparoscopic surgery with Rhubarb Peony Decoction in suppurative appendicitis. Chinese Journal of Ethnomedicine and Ethnopharmacy. 2013;11:63-64.
  68. LI Jianchao. 32 cases of chronic appendicitis treated with Dahuang Mudan decoction and Glauber's nitrate external application. Modern Traditional Chinese Medicine. 2014;34(5):32-33.
  69. FANG D R, ZHOU S G, FU S H, et al. 68 Cases' diagnosis experiences for treating the acute appendicitis merge proliferating peritonitis. Chin J Surgery Integr Tradit West Med. 2004;10(1):39-40.
  70. HAUNG J P, CHEN J Z, SUN Z L. The curative effect observation about integrated traditional and western medicine to treat appendicular abscess. Mod J Integr Tradit Chin West Med. 2008;17(19):2990-2291.
  71. ZOU Liaonan, HE Yibin, HE Junming, TAN Zhijian. Dahuang Mudan decoction plus Dachengqi Decoction retention enema observation curative effect of 36 cases of treatment of appendiceal abscess. Journal of New Chinese Medicine. 2009;41(1):59
  72. ZHANG Yonguo, HUO Chengxiang. Treatment of 87 cases of periappendiceal abscess with Dahuang Mudan decoction and Western Medicine. Shaanxi Journal of Traditional Chinese Medicine. 2009;30(5):542-543.
  73. CHANG Quanke. Efficacy observation on treatment of appendicular abscess by Dahuang Mudanpi Decoction. Clinical Journal of Chinese Medicine. 2015;7(30):86-87.
  74. HU Yingxing, HU Wangjing, WU Binbin. Clinical efficacy of Dahuang Mudan decoction in the treatment of appendiceal abscess with different ways of administration. Chinese Journal of Traditional Medical Science and Technology. 2016;23(1):62-63.
  75. YI Z J. 25 Cases about integrated traditional and western medicine to treat abdominal cavity abscess. Hubei J Tradit Chin Med. 2004;26(8):23.
  76. ZHENG T G, ZHANG Y L. 13 Cses about Dahuang Mudanpi Decoction to treat iliac fossa abscess. Xinjiang J Tradit Chin Med. 2001;19(2):4.
  77. YANG K. 53 Cases about hip bath treatment of Dahuang Mudan Decoction to anorectal disease. Hubei J Tradit Chin Med. 2002;24(11):46.
  78. YAN Y X, WANG Q X, SHEN H X, et al. The curative effect observation about Dahuang Mudan Decoction enteroclysm to treat the chronic pelvic inflammatory disease. Mod J Integr Tradit Chin West Med. 2008;17(1):56.
  79. AN L Y. Hot packs of Dahuang Mudanpi Decoction to treat the chronic pelvic inflammatory disease. Shandong J Tradit Chin Med. 2008;27(2):127.
  80. CHEN Yan, ZHAO Renxia. Clinical observation on the treatment of acute pelvic inflammatory disease with Dahuang Mudan decoction plus. Tianjin Journal of Traditional Chinese Medicine. 2009;26(5):372.
  81. MA L A, SHU C. Clinical application experiences about Dahuang Mudanpi Decoction. J Pract Tradit Chin Med. 2002;18(2):41.
  82. PENG X Z. 3 Cases for clinical application about Dahuang Mudan Decoction in gynecology. Tradit Chin Med Res. 2006;19(11):49-50.
  83. WANG L J, ZHAN W P. The curative effect observation for 20 cases about Dahuang Mudanpi Decoction to treat the acute bartholinitis. Qingdao Med J. 2000;32(3):221.
  84. Se-Bin An. A Case Study on the Bartholin's Duct Abscess treated by DahuangMudan-Tang. Journal of Korean medical association of clinical Shanghan-Geumgwe. 2012;4(1):49-56.
  85. TANG Yusheng. Observation on treatment of exogenous cough with Dahuang Mudan decoction in addition and subtraction. Seek Medical and Ask the Medicine. 2012;10(1):264.
  86. XU Y P. Clinical study for the treatment of lumbar disc protrusion by purgation of Traditional Chinese Medicine. China J Qrthop Trauma. 2005;18(3):144-145.
  87. WANG Xiaobo. Experience of Dahuang Mudan Decoction in the treatment of eye sores. Hebei Medicine. 2012;18(2):279-280.
  88. PENG Guoran, LIU Xin, HUANG Yan. Treatment of 30 cases of venous thrombosis of lower extremity by adding and reducing the acupoint application of Dahuang Mudan Decoction. China's Naturopathy. 2013;21(5):11-12.
  89. XU Xinyu, TUSU Nayi, YUAN Li. Treatment of 44 cases of thrombophlebitis of lower extremity by Dahuang Mudan Decoction plus. Journal of Emergency in Traditional Chinese Medicine. 2014;23(8):1541-1542.
  90. CHENG Wenwen. Treatment of 50 cases of uterine myoma with Dahuang Mudan decoction in addition and subtraction. Journal of Practical Traditional Chinese Medicine. 2013;29(9):733.
  91. CHEN Jia, LI Yuting. Observation of the curative effect of Dahuang Mudan decoction in the treatment of peritoneal dialysis catheter displacement. Chinese Journal of Integrated Traditional and Western Nephrology. 2016;17(8):726-727.
  92. DONG Y H. 2 Cases about new clinical application about Dahuang Mudanpi Decoction. Heilongjiang J Tradit Chin Med. 2006;(1):30-31.
  93. Gao Xue Min, Zhong Gong Sheng. Science of Chinese Materia Mmedica(Volume 1). 2nd edition. Beijing: People's Medical Publishing House, 2015: 407-408, 565-566, 577-578, 742.
  94. Gao Xue Min, Zhong Gong Sheng. Science of Chinese Materia Mmedica(Volume 2). 2nd edition. Beijing: People's Medical Publishing House, 2015: 1107-1108, 1232-1233.
  95. Chan Li. Introduction to Medicine(Volume 2). first edition. Beijing: People's Medical Publishing House, 2006: 1152.
  96. The Korean Pharmacopoeia Monographs part II. 11th Edition. Cheongju: MINISTRY OF FOOD AND DRUG SAFETY, 2016.
  97. The Korean Herbal Pharmacopoeia. Cheongju: MINISTRY OF FOOD AND DRUG SAFETY, 2016.
  98. National Pharmacopoeia Commission. Pharmacopoeia of The People's Republic of China(volume 1). 2015 edition. Beijing: China Medical Science and Technology Publishing House, 2015: 23-24, 113, 127-128, 172, 277-278.