Korean Journal of Psychosomatic Medicine (정신신체의학)

Korean Psychosomatic Society (한국정신신체의학회)
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The Relationship between Suicide Attempts and Serum Lipids in Patients Admitted with Depression

우울감을 주호소로 입원한 환자의 자살 시도와 혈청 지질과의 연관성

  • Park, Sun Hong (Department of Psychiatry, Konyang University Hospital) ;
  • Kim, Seung-Jun (Department of Psychiatry, Konyang University Hospital) ;
  • Kim, Ji-Woong (Department of Psychiatry, Konyang University Hospital) ;
  • Oh, Hong-Seok (Department of Psychiatry, Konyang University Hospital) ;
  • Lee, Sang Min (Department of Psychiatry, Kyung Hee University Hospital) ;
  • Jun, Jin Yong (Department of Psychiatry, National Center for Mental Health) ;
  • Im, Woo Young (Department of Psychiatry, Konyang University Hospital)
  • 박선홍 (건양대학교병원 정신건강의학과) ;
  • 김승준 (건양대학교병원 정신건강의학과) ;
  • 김지웅 (건양대학교병원 정신건강의학과) ;
  • 오홍석 (건양대학교병원 정신건강의학과) ;
  • 이상민 (경희대학교병원 정신건강의학과) ;
  • 전진용 (국립정신건강센터 정신건강의학과) ;
  • 임우영 (건양대학교병원 정신건강의학과)
  • Received : 2018.10.01
  • Accepted : 2018.10.23
  • Published : 2018.12.31
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Abstract

Objectives : Depression is a common mental illness and a major cause of suicide. Although serum lipids have been associated with depression and suicide, there has been much debate. In this study, we investigated the relationship between depression, suicide, and serum lipids in patients admitted with depressed mood. Methods : A total of 134 subjects were divided into 86 non-suicide patients and 48 suicide attempters. The serum lipid levels and sub-scores of the Korean Symptom Checklist-95 (KSCL95) were compared. We also investigated the relationship between serum lipids and sub-scores of KSCL95 and investigated whether serum lipids were risk factors for suicide attempts. Results : There was no difference in serum lipids between the two groups. Among the sub-items of KSCL95, obsession was higher in non-suicide group. Triglyceride showed positive correlations with anxiety, phobic anxiety, agoraphobia, schizophrenia, and self-regulation problem. High triglyceride was a risk factor for suicide attempts. Conclusions : Triglyceride is associated with depression, anxiety, and self - regulation, and high serum triglyceride levels may be a risk factor for suicide attempts.

연구목적 우울증은 흔한 정신 질환이며 자살의 주요 원인이다. 혈청 지질이 우울증, 자살과 연관이 있다는 연구가 지속되어 왔으나 아직 논란의 여지가 있다. 본 연구에서는 우울감을 주호소로 입원한 환자를 대상으로 우울과 자살, 혈청 지질과의 연관성을 조사하였다. 방 법 134명의 연구대상자를 자살 비시도자 86명, 자살 시도자 48명으로 분류하여 혈청 지질 수치, 간이정신상태 검사 II (KSCL95) 하위 항목 점수를 비교하였다. 또한 지질과 KSCL95 하위 항목의 상관 관계를 조사하였고, 혈청 지질이 자살 시도의 위험 요인으로 작용하는지 알아보았다. 결 과 두 집단은 서로 혈청 지질의 차이를 보이지 않았으나, KSCL95 하위 항목 중 강박증(obsession, OBS)이 자살 비시도군에서 더 높게 나타났다. 중성지방은 우울(depression, DEP), 공포 불안(phobic anxiety, PHOB), 광장 공포(agoraphobia, AGO), 정신증(schizophrenia, SCH), 낮은 자기 조절력(self-regulation problem, RGP) 항목과 양의 상관 관계를 보였다. 혈청 지질 중 높은 중성 지방이 자살 시도의 위험 요인으로 확인되었다. 결 론 중성 지방이 우울, 불안, 자기 조절감과 관련이 있으며, 높은 혈청 중성 지방 농도는 자살 시도의 위험 요인으로 작용하고 있음을 확인하였다.

Keywords

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Fig. 1. Correlation between KSCL95 sub-item scores and serum triglyceride levels. TG : triglyceride, DEP : depression, AGO : agoraphobia, PHOB : phobic anxiety, RGP : self-regulation problem.

Table 1. Demographic and clinical characteristics of the patients with and without suicide attempt

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Table 2. Comparisons of KSCL95 scores in the patients with and without suicide attempt

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Table 3. Comparisons of serum cholesterols level in the patients with and without suicide attempt

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Table 4. Logistic regression analysis of risk factors associated with suicide attempt

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