DOI QR코드

DOI QR Code

A Case Study of Two Alcoholic Liver Cirrhosis Patients

알코올성 간경변증 환자에 대한 치험 2례

  • Bae, Jung-han (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Joo, Seong-hee (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • An, So-yeon (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Jang, Eun-gyeong (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Kim, Young-chul (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University) ;
  • Lee, Jang-hoon (Dept. of Internal Medicine, College of Korean Medicine, Kyung Hee University)
  • 배정한 (경희대학교 한의과대학 간계내과학교실) ;
  • 주성희 (경희대학교 대학원 임상한의학과) ;
  • 안소연 (경희대학교 대학원 임상한의학과) ;
  • 장은경 (경희대학교 한의과대학 간계내과학교실) ;
  • 김영철 (경희대학교 한의과대학 간계내과학교실) ;
  • 이장훈 (경희대학교 한의과대학 간계내과학교실)
  • Received : 2018.03.19
  • Accepted : 2018.05.28
  • Published : 2018.05.30

Abstract

Objectives: To observe the treatment progress of two patients diagnosed with alcoholic liver cirrhosis. Methods: We closely observed two patients with alcoholic liver cirrhosis who had visited the Department of Hepato-hemopoietic System, Kyung Hee University Korean Medicine Hospital in 2017. They were treated with Chungganhaeju-tang and auricular acupuncture, and we evaluated the changes in their general conditions and laboratory tests. Results: In the first case, the patient underwent continuous drinking despite the treatment, and the laboratory tests showed exacerbation. During the treatment, the patient stopped drinking for one week, and both clinical symptoms and laboratory tests were slightly improved. However, overall, there were no substantial improvements. In the second case, clinical symptoms and laboratory tests were markedly improved as the patient took herbal medicine and was treated with auricular acupuncture combined with abstinence from drinking. Conclusion: Two patients with alcoholic liver cirrhosis were observed with the treatment of Chungganhaeju-tang and auricular acupuncture. A patient with continuous drinking showed no improvements while a patient with abstinence from drinking showed substantial improvements in both clinical symptoms and laboratory tests.

Keywords

References

  1. Kim DJ, Suk KT, Park SH. Epidemiologic changes of alcoholic liver disease. Korean J Hepatol 2011;17(Suppl 3):169-76.
  2. Mokdad AA, Lopez AD, Shahraz S, Lozano R, Mokdad AH, Stanaway J, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Medicine 2014;12:145. https://doi.org/10.1186/s12916-014-0145-y
  3. Jepsen P, Ott P, Andersen PK, Sorensen HT, Vilstrup H. Clinical course of alcoholic liver cirrhosis: a Danish population-based cohort study. Hepatology 2010;51(5):1675-82. https://doi.org/10.1002/hep.23500
  4. Clinical Practice Guideline for Liver Cirrhosis, Update. The Korean Association for the Study of the Liver. 2011.
  5. Veldt BJ, Laine F, Guillygomarc'h A, Lauvin L, Boudjema K, Messner M, et al. Indication of liver transplantation in severe alcoholic liver cirrhosis: quantitative evaluation and optimal timing. J Hepatol 2002;36(1):93-8. https://doi.org/10.1016/S0168-8278(01)00228-8
  6. Internal medicine(Liver system) professors in whole college of Korean Medicine. Korean internal medicine of Liver system. Seoul: Nado publishing; 2016, p. 121-3.
  7. Kwak MA, Lee JH, Woo HJ. Effects of Chungganhaeju -tang(Qingganjiejiu-tang) on Alcohol Metabolism and Alcoholic Liver Damages. J of Korean Med 2000;21(1):68-76.
  8. Han CW. The Effects of Chungganhaeju-tang on $NF{\kappa}B$ Activation and Apoptosis of Kupffer Cells. The J of Int. Korean Med 2004;25(1):59-70.
  9. Jung YJ, Lee JH, Kim YC, Woo HJ. The Effects Chungganhaeju-tang(Qingganjiejiu-tang) on Alcoholic Liver Damages by Applying Proteomics. The J of Int Korean Med 2007;28(1):68-79.
  10. Kim YT, Kim YC, Lee JH, Woo HJ. Effects of Chungganhaeju-tang on Gene Expression of Alcohol-metabolizing Enzymes and Alcohol-induced Apoptosis. The J of Int Korean Med 2003; 24(1):123-33.
  11. Kenneth C, Michelle OP, Jonathan M, Janet FM, Simon BC. NADA Ear Acupuncture: An Adjunctive Therapy to Improve and Maintain Positive Outcomes in Substance Abuse Treatment. Behavioral Sciences 2017;7(2):37. https://doi.org/10.3390/bs7020037
  12. Department of Health and Human Services and U.S. Department of Agriculture. Dietary Guidelines for Americans 2015-2020.
  13. Jonas DE, Amick HR, Feltner C, Bobashev G, Thomas K, Wines R, et al. Pharmacotherapy for adults with alcohol use disorders in outpatient settings: a systematic review and metaanalysis. JAMA 2014;311(18):1889-900. https://doi.org/10.1001/jama.2014.3628
  14. Addolorato G, Leggio L, Ferrulli A, Cardone S, Vonghia L, Mirijello A, et al. Effectiveness and safety of baclofen for maintenance of alcohol abstinence in alcohol-dependent patients with liver cirrhosis: randomised, double-blind controlled study. Lancet 2007;370(9603):1915-22. https://doi.org/10.1016/S0140-6736(07)61814-5
  15. Dario A, Tomei G. A benefit-risk assessment of baclofen in severe spinal spasticity. Drug Safety 2004;27(11):799-818. https://doi.org/10.2165/00002018-200427110-00004
  16. Yoon YK. The Effects of Chungganhaeju-tang on glutathione synthesis in HepG2 cell. The J of Int Korean Med 2004;25(1):81-91.
  17. Lee JH. The Effect of Chungganhaeju-tang on TGF-${\beta}1$-induced Hepatic Fibrosis. The J of Int Korean Med 2005;16(1):93-106.
  18. Lee JH, Park SM, Kim YC, Woo HJ. A Clinical Study of the Effects of Chungganhaeju-tang on Alcoholic Fatty Liver. J of Korean Med 2001; 22(4):107-13.
  19. Kwon SY. Lee JH. Successful Treatment of Two Patients with Alcoholic Liver Disease Using Herbal Decoction: Case Report. J of Korean Med 2012;33(2):64-72.
  20. Lee SB, Choi MY, Yang HJ, Kim YC, Woo HJ, Lee JH. Efficacy of Cheongganhaeju-tang and Ear-acupuncture Treatment about 5 Alcoholic Liver Disease Patients who Want to Quit Drinking. The J of Int Korean Med 2009;spr :141-6.
  21. Nyblom H, Berggren U, Balldin J, Olsson R. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol and Alcoholism 2004;39(4):336-9. https://doi.org/10.1093/alcalc/agh074
  22. Conigrave KM, Degenhardt LJ, Whitfield JB, Saunders JB, Helander A, Tabakoff B. CDT, GGT, and AST as markers of alcohol use: the WHO/ISBRA collaborative project. Alcohol Clin Exp Res 2002;26(3):332-9. https://doi.org/10.1111/j.1530-0277.2002.tb02542.x
  23. Leggio L, Lee MR. Treatment of alcohol use disorder in patients with alcoholic liver disease. Am J Med 2017;130(2):124-34. https://doi.org/10.1016/j.amjmed.2016.10.004
  24. Singal AK, Bataller R, Ahn J, Kamath PS, Shah VH. ACG Clinical Guideline: Alcoholic Liver Disease. The American journal of gastroenterology 2018;113(2):175-94. https://doi.org/10.1038/ajg.2017.469

Cited by

  1. 알코올성 간질환에 대한 한의학 연구 경향 분석 : 국내논문을 중심으로 vol.40, pp.3, 2019, https://doi.org/10.22246/jikm.2019.40.3.458
  2. 황달을 동반한 알코올성 간질환 환자의 한방치료 치험 1례 vol.42, pp.5, 2021, https://doi.org/10.22246/jikm.2021.42.5.949