The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats

  • Kooshki, Razieh (Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman) ;
  • Abbasnejad, Mehdi (Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman) ;
  • Mahani, Saeed Esmaeili (Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman) ;
  • Raoof, Maryam (Endodontology Research Center, Kerman University of Medical Sciences) ;
  • Aghtaei, Mohammad Mehdi Moeini (Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Kerman University of Medical Science) ;
  • Dabiri, Shahriar (Pathology and Stem Cell Research Center, Department of Pathology, Afzalipour Kerman University of Medical Science)
  • Received : 2018.03.30
  • Accepted : 2018.06.12
  • Published : 2018.07.01
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Abstract

Background: The trigeminal nucleus caudalis (Vc) is a primary central site for trigeminal transmitting. Noxious stimulation of the trigeminal nociceptors alters the central synaptic releases and neural expression of some inflammatory and trophic agents. Orexin-A and the orexin 1 receptor (OX1R) are expressed in pain pathways including trigeminal pain transmission. However, the the mechanism(s) underling orexin-A effects on trigeminal pain modulation have not been fully clarified. Methods: Trigeminal pain was induced by subcutaneous injection of capsaicin in the upper lip in rats. The effect of trigeminal pain on cyclooxygenase-2 (COX-2) and brain-derived neurotrophic factor (BDNF) expression in the Vc of animals was determined by immunofluorescence. Subsequently, OX1R agonist (orexin-A) and antagonist (SB-334867-A) was administrated in the Vc to investigate the possible roles of the Vc OX1R on changes in COX-2 and BDNF levels following pain induction. Results: The data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat. However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM). Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats.

Keywords

References

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