Journal of the Korean Applied Science and Technology (한국응용과학기술학회지)

The Korean Society of Applied Science and Technology (한국응용과학기술학회)
권호 표지
DOI QR코드

DOI QR Code

Inhibition of Adenovirus 36 Replication and Lipid Accumulation by Distylium racemosum

  • Kim, Hye-Ran (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Park, Gyu-Nam (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Jung, Bo-Kyoung (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan) ;
  • Yoon, Weon-Jong (Jeju Biodiversity Research Institute) ;
  • Chang, Kyung-Soo (Department of Clinical Laboratory Science, College of Health Sciences, Catholic University of Pusan)
  • Received : 2018.01.01
  • Accepted : 2018.06.28
  • Published : 2018.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

Obesity is a worldwide disease and one of the major risk factors. Virus among many factors can lead to obesity. Adenovirus 36 (Ad-36) is the adipogenic virus linked with human obesity. Nevertheless, there is no drug to treat both Ad-36 infection and obesity associated with virus. For the precedent study on anti-cholesterol test, Distylium racemosum (D. racemosum), Quercus salicina (Q. salicina) and Raphiolepis indica (R. indica) were selected. This study was carried out to evaluate the anti-cholesterol effects, anti-lipid effects and inhibition of Ad-36 replication from three extracts. D. racemosum ($50{\mu}g/mL$) inhibited lipid accumulation on 3T3-L1 adipocyte. D. racemosum inhibited adipocyte differentiation through suppression of regulator peroxisome proliferator-activated receptor-${\gamma}$ ($PPAR{\gamma}$) genes and adipocyte-specific genes such as adipocyte protein 2 (aP2). D. racemosum inhibited replication of Ad-36 at $50{\mu}g/mL$ of concentration. Therefore, the extract of D. racemosum could be a candidate for development of anti-Ad-36 and anti-obesity drugs.

Keywords

References

  1. World Health Organization, Health topic, http://www.who.int/topics/obesity, (accessed May., 2014)
  2. World Health Organization, 10 facts on obesity, http://www.who.int/features/factfiles/obesity, (accessed May., 2014).
  3. Y. Baek, K. Park, S. Lee, E. Jang, "The prevalence of general and abdominal obesity according to sasang constitution in Korea", BMC Complement Altern Med, Vol.14, pp. 298, (2014). https://doi.org/10.1186/1472-6882-14-298
  4. S. D. Vangipuram, J. Sheele, R.L. Atkinson, T. C. Holland, N. V. Dhurandhar, "A human adenovirus enhances preadipocyte differentiation", Obes. Res, Vol.12, No.5 pp. 770-777, (2004). https://doi.org/10.1038/oby.2004.93
  5. N. V. Dhurandhar, "Infectobesity: obesity of infectious origin", J Nutr, Vol.131, No.10 pp. 2794S-2797S, (2001). https://doi.org/10.1093/jn/131.10.2794S
  6. R. L. Atkinson, "Prevalence of infection with adenovirus-36 in Belgium and Holland and association with obesity", Obesity, Vol.19, No.1 pp. 2, (2011). https://doi.org/10.1038/oby.2010.107
  7. L. Suplicy Hde, A. Bornschein, "Infeccions as the etiology for obesity", Arq Bras Endocrinol Metabol, Vol.53, No.2 pp. 159-164, (2009). https://doi.org/10.1590/S0004-27302009000200007
  8. M. Pasarica, A. C. Shin, M. Yu, H. M. Ou Yang, M. Rathod, K. L. Jen, S. MohanKumar, P. S. MohanKumar, N. Markward, N. V. Dhurandhar, "Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats", Obesity, Vol.14, No.11 pp. 1905-1913, (2006). https://doi.org/10.1038/oby.2006.222
  9. Y. Song, H. J. Park, S. N. Kang, S. H. Jang, S. J. Lee, Y. G. Ko, G. S. Kim, J. H. Cho, "Blueberry peel extracts inhibit adipogenesis in 3T3-L1 cells and reduce high-fat diet-induced obesity", PLoS One, Vol.8, No.7 pp. e69925, (2013). https://doi.org/10.1371/journal.pone.0069925
  10. Q. Zhang, M. K. Ramlee, R. Brunmeir, C. J. Villanueva, D. Halperin, F. Xu, "Dynamic and distinct histone modifications modulate the expression of key adipogenesis regulatory genes", Cell Cycle, Vol.11, No.23 pp. 4310-4322, (2012). https://doi.org/10.4161/cc.22224
  11. V. Garcia-Alonso, C. Lopez-Vicario, E. Titos, E. Moran-Salvador, A. Gonzalez-Periz, B. Rius, M. arrizas, O. Werz, V. Arroyo, J. Claria, "Coordinate functional regulation between microsomal prostaglandin E synthase-1 (mPGES-1) and peroxisome proliferator-activated receptor ${\gamma}$ ($PPAR{\gamma}$) in the conversion of white-to-brown adipocytes", J Biol Chem, Vol.288, No.39 pp. 28230-28242, (2013). https://doi.org/10.1074/jbc.M113.468603
  12. H. J. Park, B. Y. Chung, M.K. Lee, Y. Song, S. S. Lee, G. M. Chu, S. N. Kang, Y. M. Song, G. S. Kim, J. H. Cho, "Centipede grass exerts anti-adipogenic activity through inhibition of $C/EBP{\beta}$, $C/EBP{\alpha}$, and $PPAR{\gamma}$ expression and the AKT signaling pathway in 3T3-L1 adipocytes", BMC Complement Altern Med, Vol.12, pp. 230, (2012). https://doi.org/10.1186/1472-6882-12-S1-P230
  13. J. Y. Moon, E. Y. Yim, G. SONG, N. H. Lee, C. G. Hyun, "Screening of elastase and tyrosinase inhibitory activity from Jeju Island plants", EurAsia J BioSci, Vol.4, pp. 41-53, (2010).
  14. R. K. Ko, G. O. Kim, C. G. Hyun, D. S. Jung, N. H. Lee, "Compounds with tyrosinase inhibition, elastase inhibition and DPPH radical scavenging activities from the branches of Distylium racemosum Sieb. et Zucc", Phytother Res, Vol.25, No.10 pp. 1451-1456, (2011). https://doi.org/10.1002/ptr.3439
  15. J. L. Song, X. Zhao, Q. Wang, "Protective effects of Quercus salicina on alloxan-induced oxidative stress in HIT-T15 pancreatic ${\beta}$ cells", Exp Ther Med, Vol.5, No.3 pp. 947-951, (2013). https://doi.org/10.3892/etm.2013.885
  16. T. A. Raju, A. N. Lakshmi, T. Anand, L. V. Rao, G. Sharma, "Protective effects of quercetin during influenza virus-induced oxidative stress", Asia Pac J Clin Nutr, Vol.9, No.4 pp. 314-317, (2000). https://doi.org/10.1046/j.1440-6047.2000.00162.x
  17. H. J. Park, J. Yun, S. H. Jang, S. N. Kang, B.S. Jeon, Y. G. Ko, H. D. Kim, C. K. Won, G. S. Kim, J. H. Cho, "Coprinus comatus cap inhibits adipocyte differentiation via regulation of $PPAR{\gamma}$ and Akt signaling pathway", PLoS One, Vol.9, No.9 pp. e105809, (2014). https://doi.org/10.1371/journal.pone.0105809
  18. G. S. Kim, H. J. Park, J. H. Woo, M. K. Kim, P. O. Koh, W. Min, Y. G. Ko, C. H. Kim, C. K. Won, J. H. Cho, "Citrus aurantium flavonoids inhibit adipogenesis through the Akt signaling pathway in 3T3-L1 cells", BMC Complement Altern Med, Vol.12, pp. 31, (2012).
  19. N. V. Dhurandhar, "Countering the Effects of Chronic Inflammation in Obesity", Korean J Obes, Vol.23, No.2 pp. 73-78, (2014). https://doi.org/10.7570/kjo.2014.23.2.73
  20. N. V. Dhurandhar, B. A. Israel, J. M. Kolesar, G. F. Mayhew, M. E. Cook, R. L. Atkinson, "Increased adiposity in animals due to a human virus", Int J Obes Relat Metab Disord, Vol.24, No.8 pp. 989-996, (2000). https://doi.org/10.1038/sj.ijo.0801319
  21. P. M. Rogers, K. A. Fusinski, M. A. Rathod, S. A. Loiler, M. Pasarica, M. K. Shaw, G. Kilroy, G. M. Sutton, E. J. McAllister, N. Mashtalir, J. M. Gimble, T. C. Holland, N. V. Dhurandhar, "Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene", Int J Obes, Vol.32, No.3 pp. 397-406, (2008). https://doi.org/10.1038/sj.ijo.0803748
  22. H. N. Na, S. Park, H. J. Jeon, H. B. Kim, J. H. Nam, "Reduction of adenovirus 36-induced obesity and inflammation by mulberry extract", Microbiol Immunol, Vol.58, No.5 pp. 303-306, (2014). https://doi.org/10.1111/1348-0421.12146