한국융합학회논문지 (Journal of the Korea Convergence Society)

  • 제9권8호
  • /
  • Pages.101-108
  • /
  • 2018
  • /
  • 2233-4890(pISSN)
  • /
  • 2713-6353(eISSN)
한국융합학회 (Korea Convergence Society)
권호 표지
DOI QR코드

DOI QR Code

당뇨 쥐에서 상엽추출물을 첨가한 보리면의 혈당조절효과

Effects of Barley Noodles Contained Mulberry Leave Extracts on Blood Glucose Regulation in Diabetic Mice

  • 투고 : 2018.06.15
  • 심사 : 2018.08.20
  • 발행 : 2018.08.28
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

본 연구는 상엽추출물이 포함된 보리면의 혈당조절능력을 입증하기 위하여 4주간 고지방/고탄수화물 식이 후 streptozotocin과 nicotinamide로 당뇨를 유발하고 음성대조군, 양성대조군, 보리면대조군, 상엽대조군, 보리면+상엽추출물 2.5%군, 보리면+상엽추출물 5%군의 6군으로 나누었다. 그 후 2주간 식이를 진행하며 체중, 혈당, 간 기능 및 혈액 내 지질의 변화를 측정하였다. 그 결과 보리면과 상엽 단독 섭취군보다 혼합섭취군에서 체중 감소가 적었고 혈당조절효과도 뛰어났으며 이는 경구 당 부하검사에서도 동일한 결과를 보였다. 또한 간기능, 혈중 지질 개선 효과도 혼합 섭취군에서 강하게 나타났다. 따라서, 보리면과 상엽추출물을 함유한 식이는 복합식이에서 단독식이보다 강한 혈당조절효과와 간 기능 개선, 지질 강하효과도 나타났다. 결과적으로 상엽을 포함하는 보리면은 혈당을 조절하고, 간 기능, 지질 강하 기능을 보여 만성질환 관리에도 도움이 될 것으로 사료된다.

This study aimed to investigate the blood glucose regulatory effect of barley noodles contained mulberry leaves water extract (MLWE) in diabetic mice in order to provide fundamental data as a functional food. ICR mice were divided into six groups as follows: normal control, positive control, barley control, mulberry control, barley+MLWE 2.5% and barley+MLWE 5% groups. High fat/high carbohydrate diet was fed for 4 weeks and diabetes mellitus was induced by i.p. injection of streptozotocin and nicotinamide. After diabetes induction, experimental diet was supplemented for 2 weeks and simultaneous measurement of body weight, blood glucose (including glucose tolerance test), liver function and blood lipid profile was conducted. As a result, there was less decrease in body weight compared to the positive control group in the groups that supplemented barley and MLWE together than the group ingesting barley and MLWE alone. In addition, regulatory effects on blood glucose, liver function and blood lipid concentration were also stronger in barley and MLWE concurrently supplemented groups. Consequently, combination of barley and MLWE was effective in the regulation of body weight, blood glucose, liver function, and blood lipid in diabetic mice. Therefore, this recipe could be a promising strategy for beneficial effects in the patients of diabetes mellitus.

키워드

참고문헌

  1. Final Comprehensive Global Monitoring Framework for NCDs [Internet]. WHO: [cited 2017 Feb 10]. Available from : https://www.idf.org/sites/default/files/GMF_Final%20Table%20of%20Targets.pdf.).
  2. S. K. Jang & J. S. Lee. (2017). Prevalence and Management of Dyslipidemia, Hypertension, Diabetes Among Adults in Gangwon-do, Korea: the 2013-2014 KNHSP. J of the Korea Academia-Industrial, 18(3), 625-636. DOI : 10.5762/KAIS.2017.18.1.625
  3. E.H. Jang. (2017). Quality of Life Factors and Comparative Analysis in Workers with Diabetes Mellitus in terms of Convergence : using the Korean National Health and Nutrition Examination Survey, 2007-2015. J of the Korea Convergence Society, 8(12), 167-178. DOI : 10.15207/JKCS.2017.8.12.167
  4. Diabetes Fact Sheet in Korea 2018. (2018). Korean Diabetes Association, pp.1-40.
  5. D.J. Kim. (2011). The Epidemiology of Diabetes in Korea. Diabetes Metab J. 35(4), 303-308. DOI : 10.4093/dmj.2011.35.4.303
  6. H.S. Kim. (2003). A Survey of Blood Glucose Testing, Medication, Diet, and Exercise Adherence in Korean Patients with Type2 Diabetes. J of Fundamentals of Nursing, 10(2), 181-186.
  7. J. N. Yoo, G .J. Yoo & B. K. Yoo. (2005). Exenatide: a New Agent for the Treatment of type 2 Diabetes Mellitus as Adjunctive Therapy. Kor. J. Clin. Pharm., 15(2), 165-172.
  8. J.S. Lee. (2015). A Study on Application Service for Dietary Habit Improvement of Patients with Chronic Disease - Focused on Patients with Hypertension and Diabetes. Korea Society of Design Trend, 48, 71-82. DOI : 10.21326/ksdt.2015..48.006
  9. J. H. Choi, J. H. Kang & H.M. Lee. (2014). Lifestyle, Diet, Self-care, and Diabetes Fatalism of Diabetic Patients with and without Diabetic Foot. Korean Society of Community Nutrition, 19(3), 241-249. DOI : 10.5720/kjcn.2014.19.3.241
  10. J. H. Kang. (2005). Clinical Trial of Functional Food for Weight Control. Food industry and nutrition, 10(3), 1-4.
  11. J. H. Ryu & J. O. Rho. (2013). Need for Development of a List of Meals for Diabetic Patients and Development of Barley-Based Diabetic Meals. Family and Environment Research, 51(5), 551-561. DOI : 10.6115/fer.2013.51.5.551
  12. H. K. Son, Y. M. Lee, Y. H. Park & J. J. Lee. (2016). Effect of Young Barley Leaf Powder on Glucose Control in the Diabetic Rats. Korean Society of Community Living Science, 27(1), 19-29. DOI : 10.7856/kjcls.2016.27.1.19
  13. Angeli JP, Ribeiro LR, Angeli JL, Mantovani MS. (2009). Protective effects of b-glucan extracted from barley against benzo[a]pyrene-induced DNA damage in hepatic cell HepG2. Exp Toxicol Pathol, 61(1), 83-89. DOI : 10.1016/j.etp.2008.05.003
  14. KUSMIATI, F.X.R. DHEWANTARA. (2016). Cholesterol-Lowering Effect of Beta Glucan Extracted from Saccharomyces cerevisiae in Rats. Sci Pharm, 84(1), 153-166. DOI : 10.3797/scipharm.ISP.2015.07
  15. P. Sharma, H.S. Gujral. (2010). Antioxidant and polyphenol oxidase activity of germinated barley and its milling fractions. Food Chemistry, 120(3), 673-678. DOI : 10.1016/j.foodchem.2009.10.059
  16. Y. S. Yoo, K. S. Lee, K.H. Cho, Kim, C.H. Park, S.H. Lee, J.H. Lee & D.H. Kim. (2009). Effect of barley on variation of blood glucose and lipid metabolism. Korean J. of Family Medicine, 30(10), 790-795. DOI : 10.4082/kjfm.2009.30.10.790
  17. O.G. Kim, J.C. Jeong. (2006). Effects of the Mori folium Extract in Streptozotocin-Induced Diabetic Rats. Korean J. Orient. Int. Med. 27(4), 811-821.
  18. Shimizu R, Sakazaki F, Okuno T, Nakamuro K, Ueno H. (2012). Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes.. Biomedical Research, 33(1), 63-66. DOI : 10.2220/biomedres.33.63
  19. Hunyadi A, Veres K, Danko B, Kele Z, Weber E, Hetenyi A, Zupko I, Hsieh TJ. (2013). In vitro anti-diabetic activity and chemical characterization of an apolar fraction of Morus alba leaf water extract. Phytother. Res., 27(6), 847-851. DOI : 10.1002/ptr.4803
  20. M. Y. Shon, S. Y. Choi, H. S. Cho, N. J. Sung. (2004). Effects of Cereal and Red Ginseng Flour on Blood Glucose and Lipid Level in Streptozotocin - Induced Diabetic Rats. J. Korean Society of Food Science and Nutrition, 33(9), 1463-1468. DOI : 10.3746/jkfn.2004.33.9.1463
  21. E.O. Choi, D.H. Kwon, M.Y. Kim, H. Hwang-Bo, H.J. Kim, K.I. Ahn, J.W. Jeong, K.W. Lee, K.Y. Kim, S.G. Kim, Y.W. Choi, S.H. Hong, C. Park, Y.H. Choi. (2016). Single Dose Oral Toxicity Test of Ethanol Extracts of Schisandrae fructus and Mori folium, and their Mixture in ICR Mice. J. Life Science, 26(10), 1207-1213. DOI : 10.5352/JLS.2016.26.10.1207
  22. K. M. Yang, S. R. Shin & J. H. Jang. (2006). Effect of Combined Extract of Safflower Seed with Herbs on Blood Glucose Level and Biochemical Parameters in Streptozotocin - induced Diabetic Rats. J. Korean Society of Food Science and Nutrition, 35(2), 150-157. DOI : 10.3746/jkfn.2006.35.2.150