Journal of The Korean Ophthalmological Society (대한안과학회지)

The Korean Ophthalmological Society (대한안과학회)
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Association between Normal-tension Glaucoma and Allergic Rhinitis in a Korean Population-based Study

정상안압녹내장과 알레르기비염과의 연관성: 제5기 국민건강영양조사 자료

  • Jeong, Areum (Department of Ophthalmology, Yeungnam University College of Medicine) ;
  • Cha, Soon Cheol (Department of Ophthalmology, Yeungnam University College of Medicine)
  • 정아름 (영남대학교 의과대학 안과학교실) ;
  • 차순철 (영남대학교 의과대학 안과학교실)
  • Received : 2018.05.10
  • Accepted : 2018.09.28
  • Published : 2018.10.15
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Abstract

Purpose: The purpose of this study was to investigate the association between normal-tension glaucoma (NTG) and allergic rhinitis in a population-based setting using data from the Korea National Health and Nutrition Exam Survey (2010-2012). Methods: The authors selected a total of 8,614 participants aged 40 years and older for this study. All participants completed an ophthalmic examination required for diagnosis of NTG based on the International Society for Geographical and Epidemiological Ophthalmology criteria. An interview regarding nasal symptoms was also performed. The included participants were classified into NTG (n = 604) and control (n = 8,010) groups. The authors compared the groups in terms of prevalence of allergic rhinitis and identified risk factors of NTG. Results: In NTG patients, allergic rhinitis prevalence was 29.1% (176/604), which was significantly higher than that of the control group (25.0%, 2,000/8,010; p = 0.023). There were significant associations between NTG and allergic rhinitis (odds ratio [OR]=1.34, 95% confidence interval [CI] = 1.12-1.62, p = 0.002), even after adjusting for potential confounders (age, sex, diabetes, hypertension, number, of family members, household income quartile, frequency of eating out, and smoking status). In particular, patients with NTG aged 60-69 years, those aged 70-79 years, and those who were male had significantly higher ORs for prior allergic rhinitis compared with control subjects (OR = 1.62, 95% CI = 1.16-2.26, p = 0.005; OR = 1.52, 95% CI = 1.06-2.18, p = 0.024; and OR = 1.42, 95% CI = 1.10-1.83, p = 0.007, respectively). Conclusions: This study showed a significant association between NTG incidence and allergic rhinitis, especially in males and elderly patients (>60 years of age). These results suggested that allergic rhinitis may have a potential role in the development of NTG. Therefore, ophthalmologists and allergic rhinitis patients should remain vigilant to this potential risk factor.

목적: 인구기반 역학조사 자료를 이용하여 정상안압녹내장과 알레르기비염과의 관련성을 알아보고자 하였다. 대상과 방법: 제5기 국민건강영양조사(2010-2012)에 참여한 23,379명을 대상으로 후향적 단면조사를 시행하였다. International Society for Geographical and Epidemiological Ophthalmology에서 제시한 녹내장 진단 기준에 필요한 안과 검사와 알레르기비염의 진단을 위한 설문 결과의 분석이 가능하였던 40세 이상의 대상자 8,614명을 정상안압녹내장 환자(604명)와 비녹내장 참여자(8,010명)로 분류하였다. 두 군의 알레르기비염의 유병률을 비교해 보고, 정상안압녹내장과의 관련성을 분석하였다. 결과: 정상안압녹내장군에서 알레르기비염의 유병률은 29.1% (176/604)로 대조군의 25.0% (2,000/8,010)보다 유의하게 높았다(p=0.023). 정상안압녹내장과 알레르기비염은 교란변수(나이, 성별, 당뇨병, 고혈압, 가족 수, 가계수입, 외식빈도, 흡연 여부)를 통제한 비교 분석에서 의미있는 상관관계가 있었다(교차비=1.34; 95% confidence interval [CI]=1.12-1.62; p=0.002). 60대, 70대 나이군과 남성에서 높은 교차비를 보였다(교차비=1.62; 95% CI=1.16-2.26; p=0.005, 교차비=1.52; 95% CI=1.06-2.18; p=0.024, 교차비=1.42; 95% CI=1.10-1.83; p=0.007). 결론: 정상안압녹내장과 알레르기비염은 의미있는 연관성이 있었으며 특히 60대 이상의 고령과 남성에서 더욱 높은 관련성을 보였다. 이는 알레르기비염이 정상안압녹내장의 발생에 관련이 있을 수 있음을 암시하며, 알레르기비염 환자를 진료할 때 이러한 가능성을 염두에 두어야 할 것이다.

Keywords

References

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