The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Influence of Cheongsimyeonja-tang on the Liver Function of Inpatients at the Korean Medicine Hospital

청심연자탕 복용이 한방병원 입원환자의 간 기능에 미치는 영향

  • Han, Yun-hee (School of Korean Medicine, Pusan National University) ;
  • Seo, Hee-jeong (School of Korean Medicine, Pusan National University) ;
  • Lee, In (School of Korean Medicine, Pusan National University)
  • 한윤희 (부산대학교 한의학전문대학원) ;
  • 서희정 (부산대학교 한의학전문대학원) ;
  • 이인 (부산대학교 한의학전문대학원)
  • Received : 2019.08.30
  • Accepted : 2019.11.08
  • Published : 2019.12.30
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Abstract

Background: Herbal medication is widely used in the Korean Medicine Hospital, and drug-induced liver injury (DILI) in Korea has increased proportionally. Herb-induced liver injury now accounts for approximately 40% of cases of hepatotoxicity in Korea, according to research data. Currently, however, the component responsible for the toxicity is usually unknown or can only be suspected. Objective: To study the hepatotoxicity of Cheongsimyeonja-tang in DILI. Methods: A retrospective review was conducted of 82 inpatients between April 2010 and March 2017 with suspected drug-induced liver injury (n=5). The standard criteria (RUCAM scale) for drug-induced liver injury (DILI) were applied. The electronic medical records (EMRs) were retrospectively reviewed to identify the relevant database. Aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), and total bilirubin (T. Bili) were analyzed in blood samples before and after the administration of Cheongsimyeonja-tang. Results: Five cases out of 82 patients had a criterion-referenced probable (RUCAM) score ranging from 6 to 8 points DILI. However, statistical analysis of the liver function parameters results of the 82 patients did not show a statistically meaningful elevation after taking Cheongsimyeonja-tang. Conclusions: These data suggest a relationship between Cheongsimyeonja-tang and DILI. More studies are needed to validate these observations and to explore their implications.

Keywords

References

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