Journal of Gastric Cancer

The Korean Gastric Cancer Association (대한위암학회)
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Long-term Survival Outcomes of Laparoscopic Gastrectomy for Advanced Gastric Cancer: Five-year Results of a Phase II Prospective Clinical Trial

  • Ahn, Sang-Hoon (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Kang, So Hyun (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Lee, Yoontaek (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Min, Sa-Hong (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Park, Young Suk (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Park, Do Joong (Department of Surgery, Seoul National University Bundang Hospital) ;
  • Kim, Hyung-Ho (Department of Surgery, Seoul National University Bundang Hospital)
  • Received : 2018.09.26
  • Accepted : 2019.02.25
  • Published : 2019.03.31
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Abstract

Purpose: Despite an increased acceptance of laparoscopic gastrectomy (LG) in early gastric cancer (EGC), there is insufficient evidence for its oncological safety in advanced gastric cancer (AGC). This is a prospective phase II clinical trial to evaluate the feasibility of LG with D2 lymph node dissection (LND) in AGC. Materials and Methods: The primary endpoint was set as 3-year disease-free survival (DFS). The eligibility criteria were as follows: 20-80 years of age, cT2N0-cT4aN3, American Society of Anesthesiologists score of 3 or less, and no other malignancy. Patients were enrolled in this single-arm study between November 2008 and May 2012. Exclusion criteria included cT4b or M1, or having final pathologic results as EGC. All patients underwent D2 lymphadenectomy. Three-year DFS rates were estimated by the Kaplan-Meier method. Results: A total of 157 patients were enrolled. The overall local complication rate was 10.2%. Conversion to open surgery occurred in 11 patients (7.0%). The mean follow-up period was $55.0{\pm}20.4months$ (1-81 months). The cumulative 3-year DFS rates were 76.3% for all stages, and 100%, 89.3%, 100%, 88.0%, 71.4%, and 35.3% for stage IB, IIA, IIB, IIIA, IIIB, and IIIC, respectively. Recurrence was observed in 37 patients (23.6%), including hematogenous (n=6), peritoneal (n=13), locoregional (n=1), distant node (n=8), and mixed recurrence (n=9). Conclusions: In addition to being technically feasible for treatment of AGC in terms of morbidity, LG with D2 LND for locally advanced gastric cancer showed acceptable 3-year DFS outcomes.

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