Elastomers and Composites

The Rubber Society of Korea (한국고무학회)
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Photoresponsive Nanocontainers with Ordered Porous Channels

  • Cho, Wansu (Department of Industrial Chemistry, Pukyong National University) ;
  • Kwon, Youngje (Department of Industrial Chemistry, Pukyong National University) ;
  • Park, Chiyoung (Department of Industrial Chemistry, Pukyong National University)
  • Received : 2019.06.03
  • Accepted : 2019.06.18
  • Published : 2019.06.30
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Abstract

Controlled mass transport in response to stimuli is essential for drug carriers. The complexity of the signaling system under physiological conditions has led researchers to develop precise nanocontainers that respond to stimuli in the physiological environment. Owing to several reasons, soft nanocontainers such as liposomes and micelles have been investigated for use as drug delivery systems. However, such carriers often suffer from the undesired leakage of drug molecules. In contrast, inorganic nanocontainers are robust, and their surfaces can be easily functionalized. For example, mesoporous silica nanoparticles equipped with gatekeeper molecules are increasingly being used for the controlled release of drug molecules in response to the desired stimuli. Since the development of the first hybrid nanocontainer comprising molecular machines, multiple versions of such gatekeeper systems featuring significantly improved stability and precise response to stimuli have been reported. In this study, various methods for incorporating photoresponsive nanocontainers with porous channels are developed.

Keywords

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Figure 2. Schematic illustration of the synthesis of cyclodextrincovered nanocontainers and the photocontrolled release of guest molecules from the pores.11

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Figure 3. Schematic illustration of the synthesis of cyclodextrincovered nanocontainers and the photocontrolled release of guest molecules from the pores.11

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Figure 5. (a) Photoresponsive materials functionalized with azobenzene derivatives. (b) Photoinduced release of guest molecules from mesoporous silicas functionalzed with azobenzene derivatives.13

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Figure 1. (a) Changes in UV–visible spectra of modified MCM-41 samples during UV irradiation.7 (b) A schematic overview of mechanized nanoparticles based on MSN.6

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Figure 4. (a) Absorption spectrum of Si-MP-4 in PBS (the inset shows absorption spectra of Si-MP-4 in response to UV irradiation). (b) Time dependent change in fluorescence intensity (at λem = 515 nm) of Si-MP-4 in PBS (λex = 490 nm). The inset shows fluorescence spectra of Si-MP-4 before and after UV irradiation.11

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Figure 6. Schematic illustration of the synthesis of UiO-68-azo and further construction of RhB-loaded, b-CD–capped UiO-68-azo with azobenzene units as stalks encircled by b-CD on the surface.14

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Figure 7. (a) Schematic illustration of the light triggered release. The cis-azobenzene is colored in cyan. (b) Release profiles of RhB-loaded, b-CD–capped UiO-68-azo by UV irradiation.14

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