Journal of the Korea Academia-Industrial cooperation Society (한국산학기술학회논문지)

The Korea Academia-Industrial cooperation Society (한국산학기술학회)
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The Effects of Task oriented Training on Motor and Cognitive Function in Alzheimer's Dementia Rat

과제지향훈련이 알츠하이머성 치매 흰쥐의 운동 및 인지기능에 미치는 영향

  • Lim, Gun-Hong (Department of Physical Therapy, Dongshin University) ;
  • Lee, Hong gyun (Department of Physical Therapy, Dongshin University)
  • 임건홍 (동신대학교 물리치료학과) ;
  • 이홍균 (동신대학교 물리치료학과)
  • Received : 2019.02.21
  • Accepted : 2019.07.05
  • Published : 2019.07.31
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Abstract

This study was conducted to investigate the effects of task oriented training on motor and cognitive function recovery in rats with induced Alzheimer's dementia. Thirty Sprague-Dawley rats were randomly assigned to a control group (n=15) and an experimental group (n=15). Training was given three times a week, for 20 minutes a session for 4 weeks. The cognitive and motor functions of the rats were evaluated by an eight arm radial maze test and ladder rung walk test. The eight arm radial maze test showed significant differences between groups according to the time of day 14 and 28 (p<.001). The difference in measured values according to the timing of the two groups was significant (p<.001). Additionally, there was a significant difference between the time and the group interaction (p<.001). The ladder rung walk test showed significant differences between groups according to the time of day 14 and 28 (p<.001). The difference in the measured values according to the timing of the two groups was significant (p<.001), and there was a significant difference between the time and the group interaction (p<.001). As a result, task oriented training for Alzheimer's dementia rats was found to have a positive effect on recovery of motor and cognitive function.

본 연구의 목적은 과제지향훈련이 알츠하이머 치매를 유발(${\beta}-amyloid$ 주입)시킨 흰쥐의 운동 및 인지기능 회복에 어떠한 영향을 미치는지를 알아보는 것이다. Sprague-Dawley계 흰쥐 30마리를 무작위 할당하여 치매 유발 이후 어떠한 처치도 실시하지 않은 대조군(n=15), 치매 유발 이후 과제지향훈련을 적용한 실험군(n=15)으로 나누었다. 훈련은 4주 동안 주 3회, 1일 1회, 20분간 시행하였다. 흰쥐들의 인지 및 운동기능 평가는 8자 미로 검사와 가로대 걷기 검사를 시행하였다. 8자 미로 검사는 시기별 군간 차이에서 14일과 28일에 유의한 차이를(p<.001) 보였다. 두 집단의 시기별 측정값의 차이가 유의하였다(p<.001). 또한 시기와 집단 간 상호작용도 유의한 차이가 있었다(p<.001). 사다리 걷기 검사는 시기별 군간 차이에서 14일과 28일에 유의한 차이를 보였다(p<.001). 두 집단의 시기별 측정값의 차이도 유의하였다(p<.001). 또한 시기와 집단 간 상호작용도 유의한 차이가 있었다(p<.001). 이상의 결과 알츠하이머 흰쥐에게 과제지향훈련은 운동 및 인지기능의 회복에 긍정적인 영향을 미치는 것으로 확인되었다. 더 나아가 과제지향훈련이 알츠하이머 치매환자의 운동 및 인지기능에 긍정적인 영향을 미칠 것으로 예상된다.

Keywords

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Fig. 1. Acrobatic task training

Table 1. The neurological function score in each group

SHGSCZ_2019_v20n7_119_t0001.png 이미지

Table 2. Take-time on the 8 arm radial maze test in each group

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Table 3. Comparision between groups in 8 arm radial maze test

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Table 4. The number of step error on ladder rung walk test in each group

SHGSCZ_2019_v20n7_119_t0004.png 이미지

Table 5. Comparision between groups in ladder rung walk test

SHGSCZ_2019_v20n7_119_t0005.png 이미지

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