The Journal of the Convergence on Culture Technology (문화기술의 융합)

The International Promotion Agency of Culture Technology (국제문화기술진흥원)
권호 표지
DOI QR코드

DOI QR Code

Effects of mixed supplementation on Hoveni dulcis Thunb extracts and Ginseng-Berry extracts on hangover curves

헛개과병추출물과 인삼열매추출물의 혼합 음료 섭취가 숙취해소에 미치는 효과

  • 박노환 (한국체육대학교 체육학과) ;
  • 이정옥 ((주)아리바이오) ;
  • 조인호 (한국체육대학교 운동건강관리학과)
  • Received : 2019.06.02
  • Accepted : 2019.07.10
  • Published : 2019.08.31
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to investigate the effects of ingestion of rabies and ginseng fruit extracts on alcohol hangover, liver damage protection, fatigue recovery, and physical strength improvement. A total of 64 volunteers aged over 20 were participated in this study and the randomized and repeated measures design method was used to divide a group of participants with a random assignment. All participants were divided into 4 groups (n=16) treated with hoveni dulcis thunb extract + ginseng berry extract (ARI 1000), hoveni dulcis thunb extract, ginseng berry extract, and placebo. As a result of respiratory alcohol concentration change, the group treated with ARI 1000 was significantly lower than the group treated with hoveni dulcis thunb extract, ginseng berry extract, and placebo in 1 hour of drinking, and significantly lower than the placebo group in 2 hours and 3 hours of drinking (p<0.05). After 2 and 3 hours of alcohol consumption, blood alcohol concentration of the group treated with rabies ARI 1000 was significantly lower than those of the other 3 groups (p <0.05). In conclusion, ingestion of ARI 1000 before drinking may significantly reduce the respiratory and blood alcohol concentrations, which may induce an effect on the hangover effect.

본 연구는 알코올 분해 및 간 손상 보호, 피로회복, 체력증진 등의 효과가 있는 헛개과병추출물과 인삼열매 복합추출물의 섭취가 숙취해소에 미치는 효과를 규명하는데 목적이 있다. 20세 이상 자발적으로 참여한 64명을 대상으로 무작위배정과 반복측정설계방법을 이용하여 블록무작위배정을 통해 집단 별 인원을 구성하였다. 집단 구성은 헛개과 병추출물+인삼열매 복합추출물(ARI 1000) 투여군, 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군을 각각 16명을 구성하였다. 호흡기알콜농도 변화결과 ARI 1000 투여군이 음주 1시간에서 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군에 비해 유의하게 낮았으며, 음주 2시간, 3시간에는 위약군에 비해 유의하게 낮았다(p<0.05). 혈중 알코올 농도결과 음주 2시간, 3시간 후에 ARI 1000 투여군이 헛개과병추출물투여군, 인삼열매추출물 투여군, 위약군에 비해 유의하게 낮았다(p<0.05). 결론적으로 음주 전 ARI 1000 섭취는 호흡기와 혈중 알코올 농도를 유의하게 감소시켜 숙취효과에 효능이 있는 것으로 생각된다.

Keywords

References

  1. Korea Health Statistics (2017). Korea National Health and Nutrition Examination Survey (KNHANES VII-2).
  2. Lee, H. J., & Lee, K. M. (1999). Screening of alcohol dehydrogenase inhibitors from natural products. Yakhak Hoeji, 43, 481-486.
  3. Kim, K. M., Jung, H. J., Sung, H. M., Wee, J. H., Kim, T. Y., & Kim, K. M. (2014). Study of the antioxidant and alcohol-degrading enzyme activities of soybean sprout sugar solutions. Korean Journal of Food Science and Technology, 46(5), 581-587. https://doi.org/10.9721/KJFST.2014.46.5.581
  4. Swift, R., & Davidson, D. (1998). Alcohol hangover: mechanisms and mediators. Alcohol Health & Research World, 22(1), 54-61.
  5. Oh, S., W. (2009). Effects of alcohol on obesity and metabolic syndrome. Journal of Obesity & Metabolic Syndrome, 18(1), 1-7.
  6. Chung, Y. I., Bae, I. Y., Lee, J. Y., Chun, H. S., & Lee, H. G. (2009). Protective effects of branched-chain amino acid (BCAA)-enriched corn gluten hydrolysates on ethanol-induced hepatic injury in rats. Korean Journal of Food Science and Technology.
  7. Ko, B. S., Jang, J. S., Hong, S. M., Kim, D. W., Sung, S. R., Park, H. R., ... & Park, S. M. (2006). Effect of new remedies mainly comprised of Hovenia dulcis Thunb on alcohol degradation and liver protection in Sprague Dawley male rats. Journal of the Korean Society of Food Science and Nutrition, 35(7), 828-834. https://doi.org/10.3746/JKFN.2006.35.7.828
  8. Lieber, C. S. (1995). Medical disorders of alcoholism. New England Journal of Medicine, 333(16), 1058-1065. https://doi.org/10.1056/NEJM199510193331607
  9. Sung, H. M., Jung, H. J., Yun, S. K., Kim, T. Y., Kim, K. M., & Wee, J. H. (2014). Effect of a soy-sprout beverage prepared with high-concentrated oxygen water on alcohol metabolism in rats. Korean Journal of Food Science and Technology, 46(5), 616-621. https://doi.org/10.9721/KJFST.2014.46.5.616
  10. Lieber, C. S., Garro, A., Leo, M. A., Mak, K. M., & Worner, T. (1986). Alcohol and cancer. Hepatology, 6(5), 1005-1019. https://doi.org/10.1002/hep.1840060533
  11. Kim, C. I. (1999). Cause and effect of hangover. Food Ind. Nutr, 4, 26-30.
  12. Lieber, C. S. (2004). Milestones in liver disease. J Hepatol, 40, 198-202. https://doi.org/10.1016/j.jhep.2003.12.005
  13. Swift, R., & Davidson, D. (1998). Alcohol hangover: mechanisms and mediators. Alcohol Health & Research World, 22(1), 54-61.
  14. PARK, S. C. (1993). Ethanol oxidation is accelerated by augmentation of malate-aspartate shuttle with aspartate. Experimental and Molecular Medicine, 26(2), 137-143.
  15. Yobimoto, K., Matsumoto, K., Huong, N. T. T., Kasai, R., Yamasaki, K., & Watanabe, H. (2000). Suppressive effects of Vietnamese ginseng saponin and its major component majonoside-R2 on psychological stress-induced enhancement of lipid peroxidation in the mouse brain. Pharmacology Biochemistry and Behavior, 66(3), 661-665. https://doi.org/10.1016/S0091-3057(00)00257-4
  16. Trakshel, G. M., & Maines, M. D. (1988). Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum. Biochemical Journal, 252(1), 127-136. https://doi.org/10.1042/bj2520127
  17. Simic, M. G. (1988). Mechanisms of inhibition of free-radical processes in mutagenesis and carcinogenesis. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 202(2), 377-386. https://doi.org/10.1016/0027-5107(88)90199-6
  18. Wang, C. Z., & Yuan, C. S. (2008). Potential role of ginseng in the treatment of colorectal cancer. The American journal of Chinese medicine, 36(06), 1019-1028. https://doi.org/10.1142/S0192415X08006545
  19. Nah, S. Y. (1997). Ginseng; recent advances and trends. Journal of Ginseng Research, 21(1), 1-12.
  20. Qi, L. W., Wang, C. Z., & Yuan, C. S. (2011). Ginsenosides from American ginseng: chemical and pharmacological diversity. Phytochemistry, 72(8), 689-699. https://doi.org/10.1016/j.phytochem.2011.02.012
  21. Attele, A. S., Wu, J. A., & Yuan, C. S. (1999). Ginseng pharmacology: multiple constituents and multiple actions. Biochemical pharmacology, 58(11), 1685-1693. https://doi.org/10.1016/S0006-2952(99)00212-9
  22. Lee, S. Y., Kim, Y. K., Park, N. I., Kim, C. S., Lee, C. Y., & Park, S. U. (2010). Chemical constituents and biological activities of the berry of Panax ginseng. Journal of Medicinal Plants Research, 4(5), 349-353.
  23. Wang, C. Z., Wu, J. A., McEntee, E., & Yuan, C. S. (2006). Saponins composition in American ginseng leaf and berry assayed by high-performance liquid chromatography. Journal of agricultural and food chemistry, 54(6), 2261-2266. https://doi.org/10.1021/jf052993w
  24. Xie, J. T., Wang, C. Z., Ni, M., Wu, J. A., Mehendale, S. R., Aung, H. H., ... & Yuan, C. S. (2007). American ginseng berry juice intake reduces blood glucose and body weight in ob/ob mice. Journal of food science, 72(8), S590-S594. https://doi.org/10.1111/j.1750-3841.2007.00481.x
  25. Dey, L., Xie, J. T., Wang, A., Wu, J., Maleckar, S. A., & Yuan, C. S. (2003). Anti-hyperglycemic effects of ginseng: comparison between root and berry. Phytomedicine, 10(6-7), 600-605. https://doi.org/10.1078/094471103322331908
  26. Attele, A. S., Zhou, Y. P., Xie, J. T., Wu, J. A., Zhang, L., Dey, L., ... & Yuan, C. S. (2002). Antidiabetic effects of Panax ginseng berry extract and the identification of an effective component. Diabetes, 51(6), 1851-1858. https://doi.org/10.2337/diabetes.51.6.1851
  27. Choi, H. S., Kim, S., Kim, M. J., Kim, M. S., Kim, J., Park, C. W., ... & Oh, S. W. (2018). Efficacy and safety of Panax ginseng berry extract on glycemic control: A 12-wk randomized, double-blind, and placebo-controlled clinical trial. Journal of ginseng research, 42(1), 90-97. https://doi.org/10.1016/j.jgr.2017.01.003
  28. Choi, Y. D., Park, C. W., Jang, J., Kim, S. H., Jeon, H. Y., Kim, W. G., ... & Chung, W. S. (2013). Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study. International journal of impotence research, 25(2), 45. https://doi.org/10.1038/ijir.2012.45
  29. Zhao, J. M., Li, N., Zhang, H., Wu, C. F., Piao, H. R., & Zhao, Y. Q. (2011). Novel dammarane-type sapogenins from Panax ginseng berry and their biological activities. Bioorganic & medicinal chemistry letters, 21(3), 1027-1031. https://doi.org/10.1016/j.bmcl.2010.12.035
  30. Hong, S. H., Suk, K. T., Choi, S. H., Lee, J. W., Sung, H. T., Kim, C. H., ... & Baik, S. K. (2013). Anti-oxidant and natural killer cell activity of Korean red ginseng (Panax ginseng) and urushiol (Rhus vernicifera Stokes) on non-alcoholic fatty liver disease of rat. Food and chemical toxicology, 55, 586-591. https://doi.org/10.1016/j.fct.2013.01.022
  31. Kim, S. T., Kim, H. B., Lee, K. H., Choi, Y. R., Kim, H. J., Shin, I. S., ... & Joo, S. S. (2012). Steam-dried ginseng berry fermented with Lactobacillus plantarum controls the increase of blood glucose and body weight in type 2 obese diabetic db/db mice. Journal of agricultural and food chemistry, 60(21), 5438-5445. https://doi.org/10.1021/jf300460g
  32. Ik Lee, D., Tae Kim, S., Hoon Lee, D., Min Yu, J., Kil Jang, S., & Soo Joo, S. (2014). Ginsenoside-Free Molecules from Steam- Dried Ginseng Berry Promote Ethanol Metabolism: An Alternative Choice for an Alcohol Hangover. Journal of food science, 79(7), C1323-C1330. https://doi.org/10.1111/1750-3841.12527
  33. Okuma, Y., Ishikawa, H., Ito, Y., Hayashi, Y., Endo, A., & Watanabe, T. (1995). Effect of extracts from Hovenia dulcis Thunb. alcohol concentration in rats and men administered alcohol. Journal of Japanese Society of Nutrition and Food Science (Japan).
  34. Na, C. S., Chung, N. C., Yang, K. H., Kim, S. H., Chung, H. S., & Dong, M. S. (2004). Hepatoprotective and blood alcohol lowering effects of fruit peduncle extract of Hovenia dulcis var. Koreana in the in vitro animal models. Yakhak Hoeji, 48, 34-40.
  35. Kim, S. M., Kang, S. H., Ma, J. Y., & Kim, J. H. (2006). A study on the extraction and efficacy of bioactive compound from Hovenia dulcis. KSBB Journal, 21(1), 11-15.
  36. Hase, K., Ohsugi, M., Xiong, Q., Basnet, P., Kadota, S., & Namba, T. (1997). Hepatoprotective Effect of Hovenia dulcis THUNB. on Experimental Liver Injuries Induced by Carbon Tetrachloride or D-Galactosamine: Lipopolysaccharide. Biological and pharmaceutical Bulletin, 20(4), 381-385. https://doi.org/10.1248/bpb.20.381
  37. Kim, J. S., Na, C. S., & Eun, J. B. (2005). Effect of Hovenia dulcis Thunb extract on the hyperglycemic mice induced with streptozotocin. Journal of the Korean Society of Food Science and Nutrition, 34(5), 632-637. https://doi.org/10.3746/JKFN.2005.34.5.632
  38. Lee, Y. A., Chae, H. J., & Moon, H. Y. (2005). Effect of Hovenia dulcis THUNBER var. koreana Nakai Fruits Extracts on Glucose, Lipid Metabolism and Antioxidant Activities in Streptozotocin Induced Diabetic Rat. The Korean journal of biomedical laboratory sciences, 11(4), 533-538.
  39. Hase, K., & Basnet, P. (1997). Effect of Hovenia dulcis on lipopolysaccharide-induced liver injury in chronic alcohol-fed rats. J. Trad. Med, 14, 28-33.
  40. SAKAI, K., YAMANE, T., SAITOH, Y., IKAWA, C., & NISHIHATA, T. (1987). Effect of water extracts of crude drugs in decreasing blood ethanol concentrations in rats. Chemical and pharmaceutical bulletin, 35(11), 4597-4604. https://doi.org/10.1248/cpb.35.4597
  41. Park E, M., Ye, E. J., Kim, S. J., Choi, H. I., & Bae, M. J. (2006). Eliminatory effect of health drink containing Hovenia Dulcis Thumb extract on Ethaol-induced hangover in rats. Korean J Food Culture, 21, 71-75.