Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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Malaria Parasite Separation from White Blood Cells Using Conductive Liquid-Based Standing Surface Acoustic Wave (CL-SSAW)

전도성 액체기반 정상표면탄성파(CL-SSAW)를 이용한 백혈구로부터의 말라리아 기생충 분리

  • Jee, Hyunseul (Department of Medical Sciences, Graduate School of Medicine, Korea University) ;
  • Nam, Jeonghun (Department of Laboratory Medicine, College of Medicine, Korea University Guro Hospital) ;
  • Lim, Chae Seung (Department of Laboratory Medicine, College of Medicine, Korea University Guro Hospital)
  • 지현슬 (고려대학교 의과대학 대학원 의과학과) ;
  • 남정훈 (고려대학교 구로병원 진단검사의학과) ;
  • 임채승 (고려대학교 구로병원 진단검사의학과)
  • Received : 2019.05.31
  • Accepted : 2019.09.10
  • Published : 2019.10.31
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Abstract

An acoustofluidic device using conductive liquid-based electrodes was developed for malaria parasite separation from white blood cells. In this device, the electrode channels filled with a conductive liquid were used to generate standing surface acoustic waves (SSAWs) in a fluidic channel, which can overcome the limitation of conventional patterned metal electrodes. Separation performance of the device was evaluated using fluorescent polystyrene particles with two different sizes (2 and $10{\mu}m$ diameters), which were successfully separated. In addition, a mixture of malaria parasites and white blood cells were also efficiently separated with high purity of ~98% in the CL-SSAW device at the flow rate of $12{\mu}l/min$.

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References

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