Journal of Ginseng Research

The Korean Society of Ginseng (고려인삼학회)
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Korean Red Ginseng attenuates type 2 diabetic cardiovascular dysfunction in Otsuka Long-Evans Tokushima Fatty rats

  • Hossain, Mohammad Amjad (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Lee, Dongbin (College of Veterinary Medicine, Western University of Health Sciences) ;
  • Kim, Bumseok (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kang, Chang-Won (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kim, Nam Soo (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University) ;
  • Kim, Jong-Hoon (College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University)
  • Received : 2018.08.29
  • Accepted : 2018.12.10
  • Published : 2020.03.15
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Abstract

Extracts of ginseng species show antihyperglycemic activity. We evaluated the inhibitory effects of diabetic complications for Korean Red Ginseng (KRG), which is enriched in ginsenosides using Otsuka Long-Evans Tokushima Fatty (OLETF) rats. The animals were divided into one of four groups (n = 6~9): Long-Evans-Tokushima-Otsuka rats (control rats), OLETF rats, rats given 200 mg/kg KRG, and rats given 400 mg/kg KRG. We examined the protective potential of KRG against type 2 diabetic illnesses. The results exhibited that KRG showed significant antihyperglycemic and antioxidative effects in KRG-treated OLETF rats. And, our results proposed the amelioration of cardiac function through normalized ejection fraction, fractional shortening, and vascular reactivity. Furthermore, histopathological abnormalities in the OLETF rats were prevented by KRG treatment.

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References

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