Journal of Korean Medicine Rehabilitation (한방재활의학과학회지)

The society of Korean Medicine Rehabilitation (한방재활의학과학회)
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The Effects of ChondroT on Thrombus in FeCl3-induced Rats

ChondroT 투여가 FeCl3로 유발된 혈전에 미치는 영향

  • Kim, Ji Hoon (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Kim, Sun Gil (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Kim, Joo Il (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Yoon, Chang Suk (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Choi, Ji Min (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University) ;
  • Na, Chang Su (Department of Meridian and Acupoint, College of Korean Medicine, Dongshin University) ;
  • Kim, Seon Jong (Department of Rehabilitation Medicine of Korean Medicine, College of Korean Medicine, Dongshin University)
  • 김지훈 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 김선길 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 김주일 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 윤창석 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 최지민 (동신대학교 한의과대학 한방재활의학과교실) ;
  • 나창수 (동신대학교 한의과대학 경락경혈학회) ;
  • 김선종 (동신대학교 한의과대학 한방재활의학과교실)
  • Received : 2020.06.11
  • Accepted : 2020.06.26
  • Published : 2020.07.31
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Abstract

Objectives This study was designed to investigate the effects of ChondroT on thrombus in FeCl3-induced rats. Methods We exposed FeCl3 to rat's carotid artery to induce thrombus. Specimens were divided in 5 groups; Intact, Control, ASA10 (aspirin 10 mg/kg), CT100 (ChondroT 100 mg/kg), and CT200 (ChondroT 200 mg/kg), each n=6. We investigated thromboxane, platelet activating factor (PAF), histological change, lipid metabolism, transaminase, leukocyte, erythrocyte and thrombocyte level. Results In ASA10, CT200 groups, there was significants decrease in both thromboxane level and total cholesterol level, compared to control group and there were significant histological changes of blood vessel, compared to control group. In CT200 group, there was significant decrease in PAF level, compared to control group (p<0.05). In ASA10, CT200 groups, triglycerides level tended to decrease, compared to control group. Conclusions Based on these results, it could be suggested that ChondroT was effective on thrombus in FeCl3-induced rats, and further study is needed to conduct a rigorous clinical research.

Keywords

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