Natural Product Sciences

The Korean Society of Pharmacognosy (한국생약학회)
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Fermented Product Extract with Lentinus edodes Attenuate the Inflammatory Mediators Releases and Free Radical Production

  • Shim, Sun-Yup (Department of Food Science and Biotechnology, College of Life Science and Natural Resources, Sunchon National University) ;
  • Lee, Mina (College of Pharmacy and Research Institute of Life and Pharmaceutical Sciences, Sunchon National University)
  • Received : 2021.01.27
  • Accepted : 2021.04.25
  • Published : 2021.06.30
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Abstract

Lentinus edodes contains functional metabolites such as polysaccharopeptides, lectins, and secondary metabolites. Fermented soybean paste is representative fermented materials in Korea, and is gradually increasing due to various biological activities. In the present study, ethanol extracts of fermented products with/without L. edodes were designated as SPL and SP, and prepared to develop safer and therapeutic functional foods with antioxidant and anti-inflammatory activities for treatment of inflammatory disorders. SP and SPL extracts exhibited antioxidant effects via inhibiting radical activities. Inflammatory mediators, nitric oxide (NO), prostaglandin E2 (PGE2), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor (TNF)-α, and inducible nitric oxide synthase (iNOS) production and nuclear factor-kappa B (NF-κB) activation were down-regulated by two extracts. SPL extract more strongly enhanced the antioxidant and anti-inflammatory activities than SP extract. Its' activities shown more longer fermentation period and more strong inhibitory effects. Taken together, our results suggested that fermented product with medicinal plant has synergic effect and SPL can be a potential candidate for treatment of inflammatory bowel diseases.

Keywords

Acknowledgement

This research was supported by the Ministry of Trade, Industry & Energy (MOTIE), Korea Institute for Advancement of Technology (KIAT) through the Encouragement Program for The Industries of Regional Innovation Cluster (Community business) (P0008719) and National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2020R1A2C1101252).

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