The Korea Journal of Herbology (대한본초학회지)

The Korea Association of Herbology (대한본초학회)
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Meta-analysis and Systematic Review on the Effects of Herbal Medicine and Synthetic Drugs in Helicobacter pylori Infection: Focusing on PubMED

Helicobacter pylori infection에 대한 한약과 합성의약품 병용투여 효과에 대한 메타분석 및 체계적 문헌고찰 : PubMED를 중심으로

  • Jeong, Seol (College of Korean Medicine, Sangji University) ;
  • Gwak, Seung Yeon (College of Korean Medicine, Sangji University) ;
  • Cho, Eun ji (College of Korean Medicine, Sangji University) ;
  • Jerng, Ui Min (Department of Internal medicine, College of Korean Medicine, Sangji University)
  • 정설 (상지대학교 한의과대학) ;
  • 곽승연 (상지대학교 한의과대학) ;
  • 조은지 (상지대학교 한의과대학) ;
  • 정의민 (상지대학교 한의과대학 내과학교실)
  • Received : 2021.07.30
  • Accepted : 2021.09.25
  • Published : 2021.09.30
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Abstract

Objectives : In clinical practice, there are many cases of co-administration of herbal medicine and synthetic drugs. This study tried to identify whether the combined administration of herbal medicine and synthetic drugs including amoxicillin increases Helcicobacter pylori eradication rate compared to the single administration of synthetic drugs or the combined administration of synthetic drugs and placebo herbal medicine through systematic review. Methods : Relevant randomized controlled trials were searched in PubMED database. The risk of biases was assessed through the Cochrane Risk of Bias criteria. Three reviewers were extracted the characteristics and outcomes of each study. Meta-analysis of eradication rate and adverse event was conducted. Results : Four RCTs were selected. In meta-analysis, the combination of herbal medicine and synthetic drugs showed eradication effect, but it was not statistically significant (Odds Ratio [OR] 0.46; 95% confidence interval [CI] 0.17 to 1.24; p=0.13; I2=56%) than administration of synthetic medicine alone. Combination of herbal medicine and synthetic medicine did not increased the incidence of adverse event(OR 1.07; 95% CI 0.72 to 1.59; p=0.68, I2=0%) compared to single administration of synthetic medicine. Conclusion : Although no significant difference was observed between the two groups in the eradication rate and the incidence rate of adverse events, it was difficult to draw a clear conclusion due to the heterogeneity between studies and the low quality of reporting. A number of studies that have overcome these limitations in the future will lead to definite conclusions.

Keywords

Acknowledgement

이 연구는 보건복지부의 지원을 받아 보건산업진흥원 과제 (HF20C0002)의 지원을 받아 수행되었습니다.

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