대한한방내과학회지 (The Journal of Internal Korean Medicine)

대한한방내과학회 (The Society of Internal Korean Medicine)
권호 표지
DOI QR코드

DOI QR Code

로바젯정으로 유발된 간수치 상승 환자의 한방 치료 증례 보고

A Case Report on Korean Medical Treatment of a Patient with Abnormal Liver Function Induced by Rovazet

  • 강희경 (부산대학교 한방병원 한방내과) ;
  • 조임학 (부산대학교 한방병원 한방내과) ;
  • 이찬 (부산대학교 한방병원 한방내과) ;
  • 허기윤 (부산대학교 한방병원 한방내과) ;
  • 김민화 (부산대학교 한방병원 한방내과) ;
  • 권정남 (부산대학교 한방병원 한방내과) ;
  • 김소연 (부산대학교 한방병원 한방내과) ;
  • 박성하 (부산대학교 한방병원 한방내과) ;
  • 윤영주 (부산대학교 한방병원 한방내과) ;
  • 이인 (부산대학교 한방병원 한방내과) ;
  • 최준용 (부산대학교 한방병원 한방내과) ;
  • 홍진우 (부산대학교 한방병원 한방내과) ;
  • 한창우 (부산대학교 한방병원 한방내과)
  • Kang, Hee-kyung (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Cho, Im-hak (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Lee, Chan (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Heo, Gi-yoon (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Kim, Min-hwa (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Kwon, Jung-nam (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Kim, So-yeon (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Park, Seong-ha (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Yun, Young-ju (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Lee, In (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Choi, Jun-yong (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Hong, Jin-woo (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University) ;
  • Han, Chang-woo (Dept. of Internal Medicine, Korean Medicine Hospital, Pusan National University)
  • 투고 : 2021.09.06
  • 심사 : 2021.10.22
  • 발행 : 2021.10.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objective: This study evaluated a clinical case of a patient with Rovazet-induced abnormal liver function treated with intradermal acupuncture. Method: A 59-year-old woman with abnormal liver function induced by Rovazet ceased taking the drug and instead received intradermal acupuncture treatment. After 15 days, clinical symptoms and laboratory test results were evaluated. Results: Aspartate aminotransferase and alanine aminotransferase levels decreased, and clinical symptoms such as nausea and fatigue improved after treatment with intradermal acupuncture and cessation of the Rovazet. Conclusion: This study meaningfully examined a clinical case of a patient with abnormal liver function induced by a lipid-lowering agent, which is uncommon in Korea. Unfortunately, the lack of clear evidence and the use of only one case are limitations of the study.

키워드

과제정보

본 연구는 2020년도 부산대학교 병원 임상연구비 지원으로 이루어 졌음.

참고문헌

  1. Ammar H, Rober JF. The diagnosis and management of idiosyncratic drug-induced liver injury. Liver Int 2019;39(1):31-41. https://doi.org/10.1111/liv.13931
  2. Bjornsson ES. Epidemiology, predisposing factors, and outcomes of drug-induced liver injury. Clin Liver Dis 2020;24(1):1-10 https://doi.org/10.1016/j.cld.2019.08.002
  3. European Association for the Study of the Liver. EASL Clinical Practice Guidelines: drug-induced liver injury. J Hepatol 2019;70(6):1222-61. https://doi.org/10.1016/j.jhep.2019.02.014
  4. Low EXS, Zheng Q, Chan E, Lim SG. Drug induced liver injury: East versus west. a systematic review and meta-analysis. Clinical and Molecular Hepatology 2020;26(2):142-54. https://doi.org/10.3350/cmh.2019.1003
  5. Dev K. Drug-induced liver injury. Clin Med 2016;16(6):104-9.
  6. An SY, Joo SH, Hur SY, Jang EG, Lee JH, Kim YC. A case report of efficacy of saenggan-tang on a patient with drug induced liver injury. J Int Korean Med 2019;40(2):201-7. https://doi.org/10.22246/jikm.2019.40.2.201
  7. Shin WJ, Kim TY, Park YJ, Moon JH, Ko H, Kim GT, et al. One case of drug-induced liver injury after taking gamiyukgunja-tang. Korean J Orient Int Med 2011;32(3):444-50.
  8. Lee BR, Kim WI. A case report of the effect of korean medicine on liver function test of drug-induced liver injury patient treated with western medicine. Official Journal of The Korean Medicine Society For The Herbal Formula Study 2014;22(1):193-200.
  9. Son CG. A Drug-Induced Liver Injury by Western Medication. J Int Korean Med 2015;36(1):69-75. https://doi.org/10.13048/jkm.15034
  10. Kim JH, Cho JH, Son CG. A case report for a toxic liver injury caused by voluntary administration of smilacis chinae radix. Korean J Orient Int Med 2012;33(4):609-14.
  11. Park SJ, Lee HM, Kang YK, Jeon SH, Kim JW. A case study of herbal medicine-induced liver injury improved with taeumjowe-tang(taiyintiaowei-tang). Journal of Sasang Constitutional Medicine 2010;22(2):135-42.
  12. Kim JY. Disease of digestive system. Seoul: ilchokak; 2016, p. 741-5.
  13. Kasper DL, Fauci AS, Hauser SL, Longo DL, Jameson JL, Loscalzo J. Harrison's principles medicine. 19th edition. New York: McGraw-Hill; 2015, p. 2897-99.
  14. Aida OA, Camilla S, M.Isabel L, Raul JA. Case characterization, clinical features and risk factors in drug-induced liver injury. Int J Mol Sci 2016;17(5):714. https://doi.org/10.3390/ijms17050714
  15. Benichou C, Danan G, Flahault A. Causality assessment of adverse reactions to drugs-II. An original model for validation of drug causality assessment methods: case reports with positive rechallenge. J Clin Epidemiol 1993;46(11):1331-6. https://doi.org/10.1016/0895-4356(93)90102-7
  16. Yvette NL. Rosuvastatin/ezetimibe: a review in hypercholesterolemia. Am J Cardiovasc Drugs 2020;20(4):381-92. https://doi.org/10.1007/s40256-020-00421-1
  17. Ballantyne CM. Ezetimibe: efficacy and safety in clinical trials. Eur Heart J Suppl 2002;4 (Supplement J):J9-J18. https://doi.org/10.1016/S1520-765X(02)90077-5
  18. Davidson MH, Ballantyne CM, Kerzner B, Melani L, Sager PT, Lipka L, et al. Efficacy and safety of ezetimibe coadministered with statins: randomised, placebo-controlled, blinded experience in 2382 patients with primary hypercholesterolemia. Int J Clin Pract 2002;58(8):746-55. https://doi.org/10.1111/j.1368-5031.2004.00289.x
  19. 경락경혈학 교재편찬위원회. 대한경락경혈학 제7판. 대전: 종려나무; 2016, p. 353-485.