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한방치료로 관해가 유도된 소아 크론병 환자의 증례 보고

A Case Report on Korean Medical Treatment for Induced Remission of Pediatric Crohn's Disease

  • 이현진 (경희대학교 대학원 임상한의학과) ;
  • 이하늘 (경희대학교한방병원 위장소화내과) ;
  • 정해인 (경희대학교 대학원 임상한의학과) ;
  • 조윤재 (경희대학교 대학원 임상한의학과) ;
  • 금창열 (경희대학교 대학원 임상한의학과) ;
  • 한아람 (경희대학교 대학원 임상한의학과) ;
  • 하나연 (경희대학교한방병원 위장소화내과) ;
  • 김진성 (경희대학교 대학원 임상한의학과)
  • Lee, Hyun-Jin (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Lee, Hanul (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Jeong, Hae In (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Cho, Yun-jae (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Keum, Chang-Yul (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Han, Aram (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University) ;
  • Ha, Na-yeon (Dept. of Digestive Diseases, Kyung Hee University Korean Medicine Hospital) ;
  • Kim, Jinsung (Dept. of Clinical Korean Medicine, Graduate School, Kyung Hee University)
  • 투고 : 2021.09.07
  • 심사 : 2021.10.25
  • 발행 : 2021.10.30

초록

Objectives: This case study examined the effectiveness of Korean medical treatment for pediatric Crohn's disease. Methods: A 15-year-old female Korean patient with Crohn's disease received acupuncture, electroacupuncture, herbal medicine, moxibustion, and aromatherapy treatment for 1 month in a hospital. Results: Decreases in the Pediatric Crohn's Disease Activity Index score (from 22.5 to 7.5) and the size of two abscesses (from 39.97 mm to 33.36 mm, and from 28.14 mm to 18.71 mm) according to an abdominal CT were observed following treatment. Nausea and vomiting disappeared, stool condition improved, and weight increased (from 30 kg to 33 kg) following treatment. Nausea and vomiting disappeared, stool condition improved, and weight increased (from 30 kg to 33 kg) following treatment. Conclusion: It would be worth examining the long-term effectiveness of Korean medical treatment for pediatric Crohn's disease.

키워드

참고문헌

  1. Park JJ, Yang SK, Ye BD, Kim JW, Park DI, Yoon H, et al. Second Korean Guidelines for the Management of Crohn's Disease. Korean J Gastroenterol 2017;69(1):29-54. https://doi.org/10.4166/kjg.2017.69.1.29
  2. Kim HS. Diagnosis and treatment of Crohn's disease. J Korean Med Assoc 2017;60(6):484-90. https://doi.org/10.5124/jkma.2017.60.6.484
  3. Ashton JJ, Gavin J, Beattie RM. Exclusive enteral nutrition in Crohn's disease: Evidence and practicalities. Clin Nutr 2019;38(1):80-9. https://doi.org/10.1016/j.clnu.2018.01.020
  4. Dignass A, Van Assche G, Lindsay JO, Lemann M, Soderholm J, Colombel JF, et al. The second European evidence-based Consensus on the diagnosis and management of Crohn's disease: Current management. J Crohns Colitis 2010;4(1):28-62. https://doi.org/10.1016/j.crohns.2009.12.002
  5. Lee JH. Inflammatory Bowel Disease in Pediatric Age. Korean J Pediatr Gastroenterol Nutr 2011;14(1):S34-41. https://doi.org/10.5223/kjpgn.2011.14.Suppl1.S34
  6. Cosgrove M, Al-Atia RF, Jenkins HR. The epidemiology of paediatric inflammatory bowel disease. Arch Dis Child 1996;74(5):460-1. https://doi.org/10.1136/adc.74.5.460
  7. Kim HJ, Hann HJ, Hong SN, Kim KH, Ahn IM, Song JY, et al. Incidence and natural course of inflammatory bowel disease in Korea, 2006-2012: a nationwide population-based study. Inflamm Bowel Dis 2015;21(3):623-30. https://doi.org/10.1097/MIB.0000000000000313
  8. Ko EY, Park KW, Kim HY, Jung SE, Kim WK, Min HS. Outcome of Operation in Crohn's Disease in Children. Journal of the Korean Association of Pediatric Surgeons 2005;11(2):131-40. https://doi.org/10.13029/jkaps.2005.11.2.131
  9. Van Limbergen J, Russell RK, Drummond HE, Aldhous MC, Round NK, Nimmo ER, et al. Definition of phenotypic characteristics of childhood-onset inflammatory bowel disease. Gastroenterology 2008;135(4):1114-22. https://doi.org/10.1053/j.gastro.2008.06.081
  10. Pigneur B, Seksik P, Viola S, Viala J, Beaugerie L, Girardet JP, et al. Natural history of Crohn's disease: comparison between childhood- and adult-onset disease. Inflamm Bowel Dis 2010;16(6):953-61. https://doi.org/10.1002/ibd.21152
  11. 이수찬. 반하사심탕 물 추출물의 항염증작용에 관한 연구. 국내박사학위논문 원광대학교. 2011.
  12. Dundee JW. Belfast experience with P6 acupuncture antiemesis. Ulster Med J 1990;59(1):63-70.
  13. Kong KA. Efficacy of acustimulation for post-operative nausea and vomiting : A systematic review of randomized clinical trials. Korean Academic Society of Womens Health 2012;13(1):39-54.
  14. Ho TY, Lo HY, Chao DC, Li CC, Liu JJ, Lin C, et al. Electroacupuncture improves trinitrobenzene sulfonic Acid-induced colitis, evaluated by transcriptomic study. Evid Based Complement Alternat Med 2014;2014:942196.
  15. Yan J, Zhang H, Chen CT, Yang QY, Liao WF, Chen PG. Effects of electroacupuncture at Shangjuxu (ST 37) on interleukin-1beta and interleukin-4 in the ulcerative colitis model rats. J Tradit Chin Med 2009;29(1):60-3. https://doi.org/10.1016/S0254-6272(09)60033-9
  16. Wu HG, Liu HR, Tan LY, Gong YJ, Shi Y, Zhao TP, et al. Electroacupuncture and moxibustion promote neutrophil apoptosis and improve ulcerative colitis in rats. Dig Dis Sci 2007;52(2):379-84. https://doi.org/10.1007/s10620-006-9561-y
  17. Wu HG, Zhou LB, Pan YY, Huang C, Chen HP, Shi Z, et al. Study of the mechanisms of acupuncture and moxibustion treatment for ulcerative colitis rats in view of the gene expression of cytokines. World J Gastroenterol 1999;5(6):515-7. https://doi.org/10.3748/wjg.v5.i6.515
  18. Shang HX, Wang AQ, Bao CH, Wu HG, Chen WF, Wu LY, et al. Moxibustion combined with acupuncture increases tight junction protein expression in Crohn's disease patients. World J Gastroenterol 2015;21(16):4986-96. https://doi.org/10.3748/wjg.v21.i16.4986
  19. Zhao C, Bao C, Li J, Zhu Y, Wang S, Yang L, et al. Moxibustion and Acupuncture Ameliorate Crohn's Disease by Regulating the Balance between Th17 and Treg Cells in the Intestinal Mucosa. Evid Based Complement Alternat Med 2015;2015:938054.
  20. Bao CH, Zhao JM, Liu HR, Lu Y, Zhu YF, Shi Y, et al. Randomized controlled trial: moxibustion and acupuncture for the treatment of Crohn's disease. World J Gastroenterol 2014;20(31):11000-11. https://doi.org/10.3748/wjg.v20.i31.11000
  21. Druyan ME, Compher C, Boullata JI, Braunschweig CL, George DE, Simpser E, et al. Clinical guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients: applying the GRADE system to development of A.S.P.E.N. clinical guidelines. J Parenter Enteral Nutr 2012;36(1):77-80. https://doi.org/10.1177/0148607111420157
  22. Jones VA. Comparison of total parenteral nutrition and elemental diet in induction of remission of Crohn's disease. Long-term maintenance of remission by personalized food exclusion diets. Dig Dis Sci 1987;32(12 Suppl):100S-107S. https://doi.org/10.1007/BF01312473