Korean Journal of Agricultural Science (농업과학연구)

Institute of Agricultural Science, CNU (충남대학교 농업과학연구소)
권호 표지
DOI QR코드

DOI QR Code

Supplementation of δ-aminolevulinic acid to sows' diet from day 100 of gestation to lactation improves the feed intake and red blood cells of sows and improves the birth weight of offspring

  • Qianqian, Zhang (Department of Animal Resource and Science, Dankook University) ;
  • Yanjiao, Li (Department of Animal Resource and Science, Dankook University) ;
  • In Ho, Kim (Department of Animal Resource and Science, Dankook University)
  • Received : 2022.04.15
  • Accepted : 2022.05.10
  • Published : 2022.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

This experiment was conducted to evaluate the effects of δ-aminolevulinic acid (ALA) when added to sows' diet on their reproductive performance and growth performance and on the hematology parameters of the sows and their piglets. Sixteen multiparous sows (Yorkshire × Landrace) were allotted into two treatment groups and fed basal diets (CON, piglets were injected with iron dextran) or the basal diet containing 0.1% ALA (ALA, piglets were not injected with iron dextran) from day 100 of gestation to day 28 of lactation. Supplementation of ALA had no effect on the body weight (BW), backfat thickness (BFT), or litter sizes of sows in the present experiment. However, the average daily feed intake (ADFI) of the sows was significantly improved (p < 0.05) in the ALA group. Supplementation of ALA had no effect on the growth performance or survival of suckling piglets but had a significant effect on the birth weight (p < 0.05). With regard to the blood profiles, serum concentrations of iron were unaffected in sows and piglets as compared to the control group. Red blood cell (RBC) counts were significantly improved (p < 0.05) in sows during late gestation to the time before farrowing period and in piglets at weaning. In summary, these results suggest that dietary supplementation of ALA can have positive effects by improving growth performance and blood RBC in sows and suckling piglets.

Keywords

References

  1. Ajioka RS, Phillips JD, Kushner JP. 2006. Biosynthesis of heme in mammals. Biochimica et Biophysica Acta (BBA)- Molecular Cell Research 1763:723-736. https://doi.org/10.1016/j.bbamcr.2006.05.005
  2. Anderson KE, Sassa S, Bishop DF, Desnick RJ. 2001. Disorders of heme biosynthesis: X-linked sideroblastic anemias and the porphyrias. pp. 2991-3062. In Metabolic and Molecular Bases of Inherited Disease edited by Scriver C, Beaudet A, Sly W, Valle D. McGraw-Hill, New York,
  3. Antonides A, Schoonderwoerd AC, Scholz G, Berg BM, Nordquist RE, van der Staay FJ. 2015. Pre-weaning dietary Fe deficiency impairs spatial learning and memory in the cognitive holeboard task in piglets. Frontiers in Behavioral Neuroscience 9:291. https://doi.org/10.3389/fnbeh.2015.00291
  4. Battersby AR. 2000. Tetrapyrroles: The pigments of life. Natural Product Reports 17:507-526. https://doi.org/10.1039/b002635m
  5. Buffler M, Becker C, Windisch WM. 2017. Effects of different iron supply to pregnant sows (Sus scrofa domestica L.) on reproductive performance as well as iron status of new-born piglets. Archives of Animal Nutrition 71:219-230. https://doi.org/10.1080/1745039x.2017.1301059
  6. Chen J, Wang Y, Guo X, Rao D, Zhou W, Zheng P, Ma Y. 2020. Efficient bioproduction of 5-aminolevulinic acid, a promising biostimulant and nutrient, from renewable bioresources by engineered Corynebacterium glutamicum.Biotechnology for Biofuels 13:41. https://doi.org/10.1186/s13068-020-01685-0
  7. Chen YJ, Kim IH, Cho JH, Min BJ, Yoo JS, Wang Q. 2008a. Effect of δ-aminolevulinic acid on growth performance, nutrient digestibility, blood parameters and the immune response of weanling pigs challenged with Escherichia coli lipopolysaccharide. Livestock Science 114:108-116. https://doi.org/10.1016/j.livsci.2007.04.015
  8. Chen YJ, Kim IH, Cho JH, Yoo JS, Kim HJ, Shin SO. 2008b. Utilization of delta-aminolevulinic acid for livestock: Blood characteristics and immune organ weight in broilers. Journal of Animal and Feed Science 17:215-223. https://doi.org/10.22358/jafs/66601/2008
  9. Chernova T, Smith AG. 2020. HEME IN BRAIN FUNCTIONS: POSITIVE AND NEGATIVE ROLES. In HEME BIOLOGY: Heme Acts as a Versatile Signaling Molecule Regulating Diverse Biological Processes 2020:113-161.
  10. Cho JH, Kim IH. 2011. δ-Aminolevulinic acid (ALA) as a potential feed additive in pig: A review. Journal of Animal and Veterinary Advances 10:1627-1631. https://doi.org/10.3923/javaa.2011.1627.1631
  11. Frazer DM, Anderson GJ. 2005. Iron imports. I. Intestinal iron absorption and its regulation. American Journal of Physiology-Gastrointestinal and Liver Physiology 289:G631-G635. https://doi.org/10.1152/ajpgi.00220.2005
  12. Fujii C, Miyashita K, Mitsuishi M, Sato M, Fujii K, Inoue H, Nakajima M. 2017. Treatment of sarcopenia and glucose intolerance through mitochondrial activation by 5-aminolevulinic acid. Scientific Reports 7:4013. https://doi.org/10.1038/s41598-017-03917-0
  13. Haas JD, Brownlie IVT. 2001. Iron deficiency and reduced work capacity: A critical review of the research to determine a causal relationship. The Journal of Nutrition 131:676S-690S. https://doi.org/10.1093/jn/131.2.676S
  14. Hoque MR, Ahn JM. 2021. Effects of flaxseed oil supplementation on lactating sows and their offspring. Korean Journal of Agricultural Science 48:11-19. [in Korean] https://doi.org/10.7744/KJOAS.20200059
  15. Hossain MM, Park JW, Kim IH. 2016. δ-Aminolevulinic acid, and lactulose supplements in weaned piglets diet: Effects on performance, fecal microbiota, and in-vitro noxious gas emissions. Livestock Science 183:84-91. https://doi.org/10.1016/j.livsci.2015.11.021
  16. Kang Z, Zhang J, Zhou J, Qi Q, Du G, Chen J. 2012. Recent advances in microbial production of δ-aminolevulinic acid and vitamin B12. Biotechnology Advances 30:1533-1542. https://doi.org/10.1016/j.biotechadv.2012.04.003
  17. Kommera SK, Mateo RD, Neher FJ, Kim SW. 2006. Phytobiotics and organic acids as potential alternatives to the use of antibiotics in nursery pig diets. Asian-Australasian Journal of Animal Science 19:1784-1789. https://doi.org/10.5713/ajas.2006.1784
  18. Lee SI, Li TS, Kim IH. 2016. Dietary supplementation of delta-aminolevulinic acid to lactating sows improves growth performance and concentration of iron and hemoglobin of suckling piglets. Indian Journal of Animal Science 86:781-785.
  19. Mateo RD, Morrow JL, Dailey JW, Ji F, Kim SW. 2006. Use of δ-aminolevulinic acid in swine diet: Effect on growth performance, behavioral characteristics and hematological/immune status in nursery pigs. Asian-Australasian Journal of Animal Science 19:97-101. https://doi.org/10.5713/ajas.2006.97
  20. Min BJ, Hong JW, Kwon OS, Kang DK, Kim IH. 2004. Influence of dietary δ-aminolevulinic acid supplement on growth performance and hematological changes in weaned pigs. Journal of the Korean Society of Food Science and Nutrition 33:1606-1610. [in Korean] https://doi.org/10.3746/JKFN.2004.33.10.1606
  21. NRC (National Research Council). 2012. Nutrient requirements of swine. 11th Rev. ed. National Academy Press, Washington, D.C., USA.
  22. Ogun AS, Valentine M. 2019. Biochemistry, heme synthesis. StatPearls, Treasure Island, FL, USA.
  23. Palade LM, Habeanu M, Marin DE, Chedea VS, Pistol GC, Grosu IA, Taranu I. 2019. Effect of dietary hemp seed on oxidative status in sows during late gestation and lactation and their offspring. Animals 9:194. https://doi.org/10.3390/ani9040194
  24. Pedrosa-Gerasmio IR, Kondo H, Hirono I. 2019. Dietary 5-aminolevulinic acid enhances adenosine triphosphate production, ecdysis and immune response in Pacific white shrimp,Litopenaeus vannamei (Boone). Aquacul Ture Research 50:1131-1141. https://doi.org/10.1111/are.13987
  25. Phour M, Ghai A, Rose G, Dhull N, Sindhu SS. 2018. Role of aminolevulinic acid in stress adaptation and crop productivity. Internal Journal Current Microbiology Applied Science 7:1516-1524.
  26. Sato K, Matsushita K, Takahashi K, Aoki M, Fuziwara J, Miyanari S, Kamada T. 2012. Dietary supplementation with 5-aminolevulinic acid modulates growth performance and inflammatory responses in broiler chickens. Poultry Science 91:1582-1589. https://doi.org/10.3382/ps.2010-01201
  27. Smith AD, Wilk A. 2012. Extracellular heme uptake and the challenges of bacterial cell membranes. Current Topics Membrances 69:359-392. https://doi.org/10.1016/B978-0-12-394390-3.00013-6
  28. Sonhom R, Thepsithar C, Jongsareejit B. 2012. High level production of 5-aminolevulinic acid by Propionibacterium acidipropionici grown in a low-cost medium. Biotechnology Letters 34:1667-1672. https://doi.org/10.1007/s10529-012-0943-2
  29. Tang N, Zhu Y, Zhuang H. 2015. Antioxidant and anti-anemia activity of heme iron obtained from bovine hemoglobin. Food Science and Biotechnology 24:635-642. https://doi.org/10.1007/s10068-015-0083-2
  30. Terry MJ, Smith AG. 2013. A model for tetrapyrrole synthesis as the primary mechanism for plastid-to-nucleus signaling during chloroplast biogenesis. Frontiers Plant Science 4:14. https://doi.org/10.3389/fpls.2013.00014
  31. Val-Laillet D, Elmore JS, Baines D, Naylor P, Naylor R. 2018. Long-term exposure to sensory feed additives during the gestational and postnatal periods affects sows' colostrum and milk sensory profiles, piglets' growth, and feed intake. Journal of Animal Science 96:3233-3248.
  32. Wan D, Zhang YM, Wu X, Lin X, Shu XG, Zhou XH, Li Y. 2018. Maternal dietary supplementation with ferrous N-carbamylglycinate chelate affects sow reproductive performance and iron status of neonatal piglets. Animal 12:1372-1379. https://doi.org/10.1017/S1751731117003172
  33. Wang JP, Kim HJ, Chen YJ, Yoo JS, Cho JH, Kang DK, Kim IH. 2009. Effects of delta-aminolevulinic acid and vitamin C supplementation on feed intake, backfat, and iron status in sows1. Journal of Animal Science 87:3589-3595. https://doi.org/10.2527/jas.2008-1489
  34. Wang JP, Kim IH. 2012. Effects of iron injection at birth on neonatal iron status in young pigs from first-parity sows fed delta-aminolevulinic acid. Animal Feed Science and Technology 178:151-157. https://doi.org/10.1016/j.anifeedsci.2012.08.011
  35. Wang JP, Yan L, Lee JH, Zhou TX, Kim IH. 2011. Effects of dietary delta-aminolevulinic acid and vitamin C on growth performance, immune organ weight and ferrum status in broilerchicks. Livestock Science 135:148-152. https://doi.org/10.1016/j.livsci.2010.06.161
  36. Xiong JL, Wang HC, Tan XY, Zhang CL, Naeem MS. 2018. 5-aminolevulinic acid improves salt tolerance mediated by regulation of tetrapyrrole and proline metabolism in Brassica napus L. seedlings under NaCl stress. Plant Physiology Biochemistry 124:88-99. https://doi.org/10.1016/j.plaphy.2018.01.001
  37. Yan L, Kim IH. 2011. Evaluation of dietary supplementation of delta-aminolevulinic acid and chitooligosaccharide on growth performance, nutrient digestibility, blood characteristics, and fecal microbial shedding in weaned pigs. Animal Feed Science and Technology 169:275-280. https://doi.org/10.1016/j.anifeedsci.2011.06.017
  38. Yan L, Lee JH, Meng QW, Ao X, Kim IH. 2010. Evaluation of dietary supplementation of delta-aminolevulinic acid and chito-oligosaccharide on production performance, egg quality and hematological characteristics in laying hens. Asian-Australasian Journal of Animal Science 23:1028-1033. https://doi.org/10.5713/ajas.2010.90639
  39. Youdim MBH, Gerlach M, Riederer P. 2009. Iron deficiency and excess in the brain: Implications for cognitive impairment and neurodegeneration. pp. 95-123. In Iron Deficiency and Overload: Bacic Biology to Clinical Medicine edited by Yehuda S, Mostofsky DI. Humana Press, Totowa, NJ, USA.